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25441011During DNA replication, each strand of the original molecule acts as a template for the synthesis of a new, complementary DNA strand. Featured in <a href= target="_blank"><i>The New Genetics</i></a>.3/4/2022 7:48:03 PM3/4/2022 7:48:03 PMType    Name    Media Type    File Size    Modified DNA_Replication_with_labels_S    Low 91 KB 7/28/2016 4:14 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{78EF997D-F0BC-4181-8051-F46D8EE2F0BF}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
36161167The lubber grasshopper, found throughout the southern United States, is frequently used in biology classes to teach students about the respiratory system of insects. Unlike mammals, which have red blood cells that carry oxygen throughout the body, insects have breathing tubes that carry air through their exoskeleton directly to where it's needed. This image shows the breathing tubes embedded in the weblike sheath cells that cover developing egg chambers. This image is part of the Life: Magnified collection, which was displayed in the Gateway Gallery at Washington Dulles International Airport June 3, 2014, to January 21, 2015. To see all 46 images in this exhibit, go to 9:47:06 PM11/28/2022 9:47:06 PMType    Name    Media Type    File Size    Modified 10_3_grasshopper-ovary-Edwards-3000px    Other 39595 KB 10/25/2020 9:44 PM Harris, Donald (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{E134B4F1-837B-44F9-84B7-BA084A3E76DF}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
66131284Circadian rhythms are physical, mental, and behavioral changes that follow a 24-hour cycle. Circadian rhythms are influenced by light and regulated by the brain’s suprachiasmatic nucleus (SCN), sometimes referred to as a master clock. Learn more in NIGMS’ circadian rhythms <a href="">fact sheet</a>. See <a href="">6614 </a> for the Spanish version of this infographic. 2/16/2021 3:13:58 PM2/16/2021 3:13:58 PMType    Name    Media Type    File Size    Modified CR_BrainSIZED_M    Medium 28 KB 2/12/2021 9:40 AM Walter, Taylor (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{74B01AF7-ADC8-44ED-B590-7ACFD68AA4B0}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3399746Cultured hippocampal neurons grown on a substrate of glial cells (astrocytes). The glial cells form the pink/brown underlayment in this image. The tan threads are the neurons. The round tan balls are synapses, the points where neurons meet and communicate with each other. The cover slip underlying the cells is green. Neurons in culture can be used to study synaptic plasticity, activity-dependent protein turnover, and other topics in neuroscience.12/23/2020 8:23:25 PM12/23/2020 8:23:25 PMType    Name    Media Type    File Size    Modified NCMIR_synapses_in_culture_L    Low 33 KB 6/3/2016 3:28 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{BDC54240-BDEE-4A55-879B-5913AD8C81A3}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2781720This is a magnified view of an <i>Arabidopsis thaliana</i> leaf a few days after being exposed to the pathogen <i>Hyaloperonospora arabidopsidis</i>. The plant from which this leaf was taken is genetically resistant to the pathogen. The spots in blue show areas of localized cell death where infection occurred, but it did not spread. Compare this response to that shown in Image 2782. Jeff Dangl has been funded by NIGMS to study the interactions between pathogens and hosts that allow or suppress infection.8/28/2020 7:04:24 PM8/28/2020 7:04:24 PMType    Name    Media Type    File Size    Modified Disease_resistant_leaf_L    Low 16 KB 6/3/2016 3:17 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{200A2BD2-9BDD-4BA7-AFA9-9CB33B552449}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
36191091After multiplying inside a host cell, the stringlike Ebola virus is emerging to infect more cells. Ebola is a rare, often fatal disease that occurs primarily in tropical regions of sub-Saharan Africa. The virus is believed to spread to humans through contact with wild animals, especially fruit bats. It can be transmitted between one person and another through bodily fluids. This image is part of the Life: Magnified collection, which was displayed in the Gateway Gallery at Washington Dulles International Airport June 3, 2014, to January 21, 2015. To see all 46 images in this exhibit, go to 8:33:21 PM11/22/2022 8:33:21 PMType    Name    Media Type    File Size    Modified 7_topleft_Ebola_2-ZEBOV_Vero_E6_ATCC_72h_m021_L    Low 247 KB 6/3/2016 3:34 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{0E4D5E79-C23A-4BA4-BB9A-4CF2B42CE408}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3400747Blood vessels at the back of the eye (retina) are used to diagnose glaucoma and diabetic eye disease. They also display characteristic changes in people with high blood pressure. In the image, the vessels appear green. It's not actually the vessels that are stained green, but rather filaments of a protein called actin that wraps around the vessels. Most of the red blood cells were replaced by fluid as the tissue was prepared for the microscope. The tiny red dots are red blood cells that remain in the vessels. The image was captured using confocal and 2-photon excitation microscopy for a project related to neurofibromatosis.12/23/2020 8:25:40 PM12/23/2020 8:25:40 PMType    Name    Media Type    File Size    Modified NCMIR_vasculature1    High 381 KB 6/3/2016 3:28 PM aamishral2 (NIH/NIGMS) [C The tiny red dots are red blood STS_ListItem_DocumentLibrary{1233873B-4276-4C11-861B-FE6A348B950C}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3295526Researchers use cluster analysis to study protein shape and function. Each green circle represents one potential shape of the protein mitoNEET. The longer the blue line between two circles, the greater the differences between the shapes. Most shapes are similar; they fall into three clusters that are represented by the three images of the protein. From a Rice University <a href= target="_blank">news release</a>. Graduate student Elizabeth Baxter and Patricia Jennings, professor of chemistry and biochemistry at UCSD, collaborated with José Onuchic, a physicist at Rice University, on this work.12/22/2020 10:54:21 PM12/22/2020 10:54:21 PMType    Name    Media Type    File Size    Modified Cluster_analysis_of_mysterious_protein_L    Low 46 KB 6/3/2016 3:26 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{CD831F69-EC6F-4495-8D60-9CA97CADEEBB}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3489952To develop a system for studying cell motility in unnatrual conditions -- a microscope slide instead of the body -- Tom Roberts and Katsuya Shimabukuro at Florida State University disassembled and reconstituted the motility parts used by worm sperm cells.9/8/2020 11:09:41 PM9/8/2020 11:09:41 PMType    Name    Media Type    File Size    Modified Roberts_cool_image    High 36 KB 6/3/2016 3:30 PM aamishral2 (NIH/NIGMS) [C> wrote: Dear Dr. Roberts STS_ListItem_DocumentLibrary{56D4D731-F837-44AD-BCAE-9A46C68B1083}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
35181076Scanning electron micrograph of just-divided HeLa cells. Zeiss Merlin HR-SEM. See related images 3519,3520,3521,3522.9/27/2020 3:27:26 AM9/27/2020 3:27:26 AMType    Name    Media Type    File Size    Modified HeLaV_L    Low 119 KB 6/3/2016 3:30 PM aamishral2 (NIH/NIGMS) [C National Center for Microscopy and Imaging STS_ListItem_DocumentLibrary{DF35293D-4426-449F-97F4-E899122B7824}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2432682Cell showing overproduction of the ARTS protein (red). ARTS triggers apoptosis, as shown by the activation of caspase-3 (green) a key tool in the cell's destruction. The nucleus is shown in blue. Image is featured in October 2015 Biomedical Beat blog post <a href="" target="_">Cool Images: A Halloween-Inspired Cell Collection</a>.8/18/2020 9:19:05 PM8/18/2020 9:19:05 PMType    Name    Media Type    File Size    Modified ARTS_triggers_apoptosis    High 81 KB 6/3/2016 3:11 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{5E4EB106-B5AB-408D-802C-F9AD60D9DC04}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
65931218Cell-like compartments that spontaneously emerged from scrambled frog eggs, with nuclei (blue) from frog sperm. Endoplasmic reticulum (red) and microtubules (green) are also visible. Image created using confocal microscopy. <br> <p>For more photos of cell-like compartments from frog eggs view: <a href="">6584</a>, <a href="">6585</a>, <a href="">6586</a>, <a href="">6591</a>, <a href="">6592</a>.</p> <p>For videos of cell-like compartments from frog eggs view:&nbsp;<a href="">6587</a>, <a href="">6588</a>, <a href="">6589</a>, and <a href="">6590</a>.</p>9/13/2020 3:39:51 PM9/13/2020 3:39:51 PMType    Name    Media Type    File Size    Modified img6_cheng_confocal_nuc_t76_M    Medium 62 KB 9/15/2020 10:04 AM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{552FC5C2-8EFE-4A87-9B6E-FE57AED81528}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2318587Pretty in pink, the enzyme histone deacetylase (HDA6) stands out against a background of blue-tinted DNA in the nucleus of an <i>Arabidopsis</i> plant cell. Here, HDA6 concentrates in the nucleolus (top center), where ribosomal RNA genes reside. The enzyme silences the ribosomal RNA genes from one parent while those from the other parent remain active. This chromosome-specific silencing of ribosomal RNA genes is an unusual phenomenon observed in hybrid plants. Featured in the June 20, 2006, issue of <a href= target="_blank"><em>Biomedical Beat</em></a>.10/29/2020 1:20:57 PM10/29/2020 1:20:57 PMType    Name    Media Type    File Size    Modified 2318_gene_S    Low 59 KB 3/29/2019 1:50 PM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{9AF8AC6D-4C9B-4230-A633-C6B5C804DB6C}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3604965Along with blood vessels (red) and nerve cells (green), this mouse brain shows abnormal protein clumps known as plaques (blue). These plaques multiply in the brains of people with Alzheimer's disease and are associated with the memory impairment characteristic of the disease. Because mice have genomes nearly identical to our own, they are used to study both the genetic and environmental factors that trigger Alzheimer's disease. Experimental treatments are also tested in mice to identify the best potential therapies for human patients. This image is part of the Life: Magnified collection, which was displayed in the Gateway Gallery at Washington Dulles International Airport June 3, 2014, to January 21, 2015. To see all 46 images in this exhibit, go to 7:23:52 PM11/22/2022 7:23:52 PMType    Name    Media Type    File Size    Modified 10_alzheimerbrain_s_T    Thumbnail 5 KB 6/3/2016 3:33 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{5E098B48-2D3B-477A-82C0-1A20292EAF17}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3460549Recombinant proteins such as the prion protein shown here are often used to model how proteins misfold and sometimes polymerize in neurodegenerative disorders. This prion protein was expressed in E. coli, purified and fibrillized at pH 7. Image taken in 2004 for a research project by Roger Moore, Ph.D., at Rocky Mountain Laboratories that was published in 2007 in <i>Biochemistry</i>. This image was not used in the publication.8/31/2020 4:08:32 AM8/31/2020 4:08:32 AMType    Name    Media Type    File Size    Modified fibril_L    Low 57 KB 6/3/2016 3:29 PM aamishral2 (NIH/NIGMS) [C Recombinant proteins such as the prion STS_ListItem_DocumentLibrary{D61A0D04-06B0-47B0-B82D-4FEDA379609F}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2755507<i>Xenopus laevis</i>, the African clawed frog, has long been used as a model organism for studying embryonic development. The abnormal presence of RNA encoding the signaling molecule plakoglobin causes atypical signaling, giving rise to a two-headed tadpole.7/14/2021 6:20:28 PM7/14/2021 6:20:28 PMType    Name    Media Type    File Size    Modified Klym2_S    Low 90 KB 9/7/2016 6:12 PM Varkala, Venkat (NIH/NIGMS) [C AZM obtained this image from Dr STS_ListItem_DocumentLibrary{7A0154DE-CDD8-4B46-B04F-627CC4245B9C}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2514816HIV is a retrovirus, a type of virus that carries its genetic material not as DNA but as RNA. Long before anyone had heard of HIV, researchers in labs all over the world studied retroviruses, tracing out their life cycle and identifying the key proteins the viruses use to infect cells. When HIV was identified as a retrovirus, these studies gave AIDS researchers an immediate jump-start. The previously identified viral proteins became initial drug targets. See images <a href="">2513</a> and <a href="">2515</a> for other versions of this illustration. Featured in <a href= target="_blank"><i>The Structures of Life</i></a>.9/25/2020 4:29:40 PM9/25/2020 4:29:40 PMType    Name    Media Type    File Size    Modified 2514_Life_of_an_AIDS_Virus_with_labels_T    Thumbnail 117 KB 4/19/2019 12:29 PM Constantinides, Stephen (NIH STS_ListItem_DocumentLibrary{7C26D3D2-FF70-420C-A0BC-1E2725806E59}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3606966In plants, as in animals, stem cells can transform into a variety of different cell types. The stem cells at the growing tip of this Arabidopsis plant will soon become flowers. Arabidopsis is frequently studied by cellular and molecular biologists because it grows rapidly (its entire life cycle is only 6 weeks), produces lots of seeds and has a genome that is easy to manipulate. This image is part of the Life: Magnified collection, which was displayed in the Gateway Gallery at Washington Dulles International Airport June 3, 2014, to January 21, 2015. To see all 46 images in this exhibit, go to 9:02:36 PM11/22/2022 9:02:36 PMType    Name    Media Type    File Size    Modified 5_topmid_Flower_cell_plant    Other 3073 KB 10/25/2020 7:49 PM Harris, Donald (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{69D49AC0-B619-4A4C-A1D9-072FB68B5234}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
69331269Various views of a zebrafish head with blood vessels shown in purple. Researchers often study zebrafish because they share many genes with humans, grow and reproduce quickly, and have see-through eggs and embryos, which make it easy to study early stages of development. <Br><Br> This video was captured using a light sheet microscope. <Br><Br> Related to image <a href="">6934</a>. 3/28/2023 7:28:33 PM3/28/2023 7:28:33 PMType    Name    Media Type    File Size    Modified Zebrafish    High 79865 KB 3/28/2023 2:27 PM Bigler, Abbey (NIH/NIGMS) [C Br><Br> This video was captured using a STS_ListItem_DocumentLibrary{51C6DED5-0B9A-4BCB-BB8C-2DEF96D5D9F7}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2571831This video shows the structure of the pore-forming protein VDAC-1 from humans. This molecule mediates the flow of products needed for metabolism--in particular the export of ATP--across the outer membrane of mitochondria, the power plants for eukaryotic cells. VDAC-1 is involved in metabolism and the self-destruction of cells--two biological processes central to health. Relates to a <a href= target="_blank">September 4, 2008 news release</a>.3/4/2022 7:28:57 PM3/4/2022 7:28:57 PMType    Name    Media Type    File Size    Modified 2571_VDAC_video_02_T    Thumbnail 83 KB 3/29/2019 11:13 AM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{7A695641-F7C2-4B40-8E22-3DC1F1AF3080}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
69621238A <em>Trigonium</em> diatom imaged by a quantitative orientation-independent differential interference contrast (OI-DIC) microscope. Diatoms are single-celled photosynthetic algae with mineralized cell walls that contain silica and provide protection and support. These organisms form an important part of the plankton at the base of the marine and freshwater food chains. The width of this image is 90 μm. <Br><Br> More information about the microscopy that produced this image can be found in the <em>Journal of Microscopy</em> paper <a href="">“An Orientation-Independent DIC Microscope Allows High Resolution Imaging of Epithelial Cell Migration and Wound Healing in a Cnidarian Model”</a> by Malamy and Shribak. 1/27/2023 9:46:30 PM1/27/2023 9:46:30 PMType    Name    Media Type    File Size    Modified Trigonium_M    Medium 692 KB 1/27/2023 4:29 PM Bigler, Abbey (NIH/NIGMS) [C The image width is 90 μm STS_ListItem_DocumentLibrary{F78335F9-FB37-4883-9939-AEB00AE242F9}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
36561171A fruit fly ovary, shown here, contains as many as 20 eggs. Fruit flies are not merely tiny insects that buzz around overripe fruit--they are a venerable scientific tool. Research on the flies has shed light on many aspects of human biology, including biological rhythms, learning, memory and neurodegenerative diseases. Another reason fruit flies are so useful in a lab (and so successful in fruit bowls) is that they reproduce rapidly. About three generations can be studied in a single month. Related to image <a href="" target="_blank">3607</a>.11/30/2020 9:10:22 PM11/30/2020 9:10:22 PMType    Name    Media Type    File Size    Modified pink_fruit_fly_ovary_Montell_L    Low 39 KB 6/3/2016 3:37 PM aamishral2 (NIH/NIGMS) [C So use them as much as STS_ListItem_DocumentLibrary{6325F483-590F-4766-AAE7-6279A5EB29B9}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2803855Rendering of the surface of an endothelial cell; membrane curvature is color coded. This is an example of NIH-supported research on single cell analysis. Related to <a href="">image 2798</a> , <a href="">image 2799</a>, <a href="">image 2800</a>, <a href="">image 2801</a>, and <a href="">image 2802</a>.9/11/2020 4:32:59 PM9/11/2020 4:32:59 PMType    Name    Media Type    File Size    Modified nih11Cell3Dcurvature_S    Low 95 KB 8/24/2016 3:37 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{18E989EA-5A20-427E-B31D-B838FCD2557C}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3403938Disassembly of vasculature in kdr:GFP frogs following addition of 250 µM TBZ.12/23/2020 8:31:47 PM12/23/2020 8:31:47 PMType    Name    Media Type    File Size    Modified Disrupted_vascular_development_in_frog_embryos    High 4190 KB 6/3/2016 3:28 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{10F5BCA0-1B0C-4B6A-BE65-1D13C135E833}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
34921146This tropical scene, reminiscent of a postcard from Key West, is actually a petri dish containing an artistic arrangement of genetically engineered bacteria. The image showcases eight of the fluorescent proteins created in the laboratory of the late Roger Y. Tsien, a cell biologist at the University of California, San Diego. Tsien, along with Osamu Shimomura of the Marine Biology Laboratory and Martin Chalfie of Columbia University, share the 2008 Nobel Prize in chemistry for their work on green fluorescent protein-a naturally glowing molecule from jellyfish that has become a powerful tool for studying molecules inside living cells.9/9/2020 1:51:26 AM9/9/2020 1:51:26 AMType    Name    Media Type    File Size    Modified cool_image_colored_proteins1_M    Medium 103 KB 8/30/2016 12:30 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{82113CDA-7154-491B-8100-C43A4925AAC1}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
1275769The Golgi complex, also called the Golgi apparatus or, simply, the Golgi. This organelle receives newly made proteins and lipids from the ER, puts the finishing touches on them, addresses them, and sends them to their final destinations. Appears in the NIGMS booklet <a href="" target="_blank"><i>Inside the Cell</i></a>.10/28/2020 4:29:29 PM10/28/2020 4:29:29 PMType    Name    Media Type    File Size    Modified ITC_Golgi_inset_Copy_M    Medium 28 KB 10/28/2020 12:29 PM McCulley, Jennifer (NIH/NIDCD) [C STS_ListItem_DocumentLibrary{F1ACB139-25A3-4C54-8EE3-575084FC6DB6}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
58151198Genome editing using CRISPR/Cas9 is a rapidly expanding field of scientific research with emerging applications in disease treatment, medical therapeutics and bioenergy, just to name a few. This technology is now being used in laboratories all over the world to enhance our understanding of how living biological systems work, how to improve treatments for genetic diseases and how to develop energy solutions for a better future.12/18/2020 8:24:01 PM12/18/2020 8:24:01 PMType    Name    Media Type    File Size    Modified doudna video    Thumbnail 832 KB 12/20/2016 1:20 PM Varkala, Venkat (NIH/NIGMS) [C And if the answer is yes STS_ListItem_DocumentLibrary{9583BEF7-4257-4FF7-AC04-5362F743D198}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
67501245These microscopic roundworms, called <i>Caenorhabditis elegans</i>, lack eyes and the opsin proteins used by visual systems to detect colors. However, researchers found that the worms can still sense the color of light in a way that enables them to avoid pigmented toxins made by bacteria. This image was captured using a stereo microscope.3/24/2021 5:44:57 PM3/24/2021 5:44:57 PMType    Name    Media Type    File Size    Modified Ghosh et al_SciPak multimedia 1_2.24.2021_M    Medium 42 KB 3/24/2021 11:16 AM Walter, Taylor (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{760D483D-C76B-4606-BCD1-4887E3807BC8}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2368791Automated methods using micromachined silicon are used at the Northeast Collaboratory for Structural Genomics to mount protein crystals for X-ray crystallography.10/29/2020 4:20:47 PM10/29/2020 4:20:47 PMType    Name    Media Type    File Size    Modified hi_nesg4_crystalmt_L    Low 35 KB 6/3/2016 3:09 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{6F34EFEE-C10B-4FAD-AEBF-F450BA7F39C6}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2484490NIGMS-funded researchers led by Roger Kornberg solved the structure of RNA polymerase II. This is the enzyme in mammalian cells that catalyzes the transcription of DNA into messenger RNA, the molecule that in turn dictates the order of amino acids in proteins. For his work on the mechanisms of mammalian transcription, Kornberg received the Nobel Prize in Chemistry in 2006.9/18/2020 5:05:13 PM9/18/2020 5:05:13 PMType    Name    Media Type    File Size    Modified RNA_pol_II_medium    Medium 1184 KB 6/3/2016 3:12 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{2A10BFFD-1037-418C-890C-8D7FB32E4ED7}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
63521309This image shows how the CRISPR surveillance complex is disabled by two copies of anti-CRISPR protein AcrF1 (red) and one AcrF2 (light green). These anti-CRISPRs block access to the CRISPR RNA (green tube) preventing the surveillance complex from scanning and targeting invading viral DNA for destruction. 12/21/2020 5:09:58 PM12/21/2020 5:09:58 PMType    Name    Media Type    File Size    Modified CRISPR 2 of 2 NRAMM    High 197 KB 11/29/2017 11:59 AM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{152D7892-75BF-4DA9-913D-B1FCC618DA85}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
7009385877Macrophages (green) are the professional eaters of our immune system. They are constantly surveilling our tissues for targets—such as bacteria, dead cells, or even cancer—and clearing them before they can cause harm. In this image, researchers were testing how macrophages responded to different molecules that were attached to silica beads (magenta) coated with a lipid bilayer to mimic a cell membrane. <Br><Br>Find more information on this image in the <em>NIH Director’s Blog</em> post <a href="">"How to Feed a Macrophage."</a> 3/1/2024 4:48:40 PM3/1/2024 4:48:40 PMType    Name    Media Type    File Size    Modified hungryhungrymacs_bond_M    Medium 350 KB 3/1/2024 10:55 AM Bigler, Abbey (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{FB87E3AA-944C-4767-8AE5-F2348FF36B73}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
65721276The 3D single-molecule super-resolution reconstruction of the entire nuclear lamina in a HeLa cell was acquired using the TILT3D platform. TILT3D combines a tilted light sheet with point-spread function (PSF) engineering to provide a flexible imaging platform for 3D single-molecule super-resolution imaging in mammalian cells. <br> See <a href="">6573</a> for 3 seperate views of this structure.<br>12/22/2020 3:20:41 PM12/22/2020 3:20:41 PMType    Name    Media Type    File Size    Modified NuclearLamina_300dpi_M    Medium 117 KB 7/16/2020 5:42 PM Harris, Donald (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{D065B67F-284D-48AA-98C1-513E4A756EF1}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
58781053Misfolded proteins (green) within mitochondria (red). Related to video <a href="">5877</a>.12/18/2020 9:46:22 PM12/18/2020 9:46:22 PMType    Name    Media Type    File Size    Modified mitochondria and misfolded proteins_M    Medium 11 KB 5/4/2017 2:35 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{D6576F1E-7F5E-4062-8A63-1ED33195376C}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3392742Stained glomeruli in the kidney. The kidney is an essential organ responsible for disposing wastes from the body and for maintaining healthy ion levels in the blood. It works like a purifier by pulling break-down products of metabolism, such as urea and ammonium, from the blood stream for excretion in urine. The glomerulus is a structure that helps filter the waste compounds from the blood. It consists of a network of capillaries enclosed within a Bowman's capsule of a nephron, which is the structure in which ions exit or re-enter the blood in the kidney.12/23/2020 8:07:21 PM12/23/2020 8:07:21 PMType    Name    Media Type    File Size    Modified NCMIR_kidney_glomereolus_L    Low 34 KB 6/3/2016 3:28 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{91D93B75-49F2-41DB-9621-4ABF190E134E}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
37711039Viruses have been the foes of animals and other organisms for time immemorial. For almost as long, they've stayed well hidden from view because they are so tiny (they aren't even cells, so scientists call the individual virus a "particle"). This image shows a molecular model of a particle of the Rous sarcoma virus, a virus that infects and sometimes causes cancer in chickens. In the background is a photo of red blood cells. The particle shown is "immature" (not yet capable of infecting new cells) because it has just budded from an infected chicken cell and entered the bird's bloodstream. The outer shell of the immature virus is made up of a regular assembly of large proteins (shown in red) that are linked together with short protein molecules called peptides (green). This outer shell covers and protects the proteins (blue) that form the inner shell of the particle. But as you can see, the protective armor of the immature virus contains gaping holes. As the particle matures, the short peptides are removed and the large proteins rearrange, fusing together into a solid sphere capable of infecting new cells. While still immature, the particle is vulnerable to drugs that block its development. Knowing the structure of the immature particle may help scientists develop better medications against RSV and similar viruses in humans. Scientists used sophisticated computational tools to reconstruct the RSV atomic structure by crunching various data on the RSV proteins to simulate the entire structure of immature RSV. For more on RSV and how researchers revealed its delicate structure, see the NIH director's blog post <a href="">Snapshots of Life: Imperfect but Beautiful Intruder.</a>12/17/2020 6:39:16 PM12/17/2020 6:39:16 PMType    Name    Media Type    File Size    Modified Imperfect_intruder_for_NIH    High 9721 KB 6/3/2016 3:41 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{A147967A-CD83-453D-8FF9-DC930253A9F5}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
65681272These images illustrate a technique combining cryo-electron tomography and super-resolution fluorescence microscopy called correlative imaging by annotation with single molecules (CIASM). CIASM enables researchers to identify small structures and individual molecules in cells that they couldn’t using older techniques. 12/22/2020 3:22:47 PM12/22/2020 3:22:47 PMType    Name    Media Type    File Size    Modified Figure_2_72dpi    Thumbnail 63 KB 7/16/2020 3:27 PM Harris, Donald (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{93F7C98F-C6A0-4FA2-A019-AA17C2A1B17F}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2426677The structure of a gene-regulating zinc finger protein bound to DNA.8/17/2020 9:31:43 PM8/17/2020 9:31:43 PMType    Name    Media Type    File Size    Modified DesignedZF    High 595 KB 6/3/2016 3:10 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{05B06D12-30DC-46F0-97A0-41AAFF3B328B}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6997355213<em>E. coli</em> bacteria normally live harmlessly in our intestines, but some cause disease by making toxins. One of these toxins, called Shiga toxin (green), inactivates host ribosomes (purple) by mimicking their normal binding partners, the EF-Tu elongation factor (red) complexed with Phe-tRNAPhe (orange). <Br><Br> Find these in the RCSB Protein Data Bank: <a href="">Shiga toxin 2</a> (PDB entry 7U6V) and <a href="">Phe-tRNA</a> (PDB entry 1TTT). <Br><Br> More information about this work can be found in the <em>J. Biol. Chem.</em> paper <a href="">"Cryo-EM structure of Shiga toxin 2 in complex with the native ribosomal P-stalk reveals residues involved in the binding interaction"</a> by Kulczyk et. al. 2/13/2024 8:28:27 PM2/13/2024 8:28:27 PMType    Name    Media Type    File Size    Modified shiga-pstalk-large_M    Medium 101 KB 2/2/2024 3:31 PM Crowley, Rachel (NIH/NIGMS) [E STS_ListItem_DocumentLibrary{F3B87863-A320-40EB-9AEA-C87F7BBEF203}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
65921217Cell-like compartments that spontaneously emerged from scrambled frog eggs, with nuclei (blue) from frog sperm. Endoplasmic reticulum (red) and microtubules (green) are also visible. Image created using confocal microscopy. <br> <p>For more photos of cell-like compartments from frog eggs view: <a href="">6584</a>, <a href="">6585</a>, <a href="">6586</a>, <a href="">6591</a>, and <a href="">6593</a>.</p> <p>For videos of cell-like compartments from frog eggs view:&nbsp;<a href="">6587</a>, <a href="">6588</a>, <a href="">6589</a>, and <a href="">6590</a>.</p>9/13/2020 3:38:40 PM9/13/2020 3:38:40 PMType    Name    Media Type    File Size    Modified img5_cheng_confocal_nuc_t40_M    Medium 66 KB 9/15/2020 10:07 AM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{10111D22-D87A-4A9F-82B8-5C98DB9E5D44}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
69631239Real-time footage of <em>Caenorhabditis elegans</em>, a tiny roundworm, trapped by a carnivorous fungus, <em>Arthrobotrys dactyloides</em>. This fungus makes ring traps in response to the presence of <em>C. elegans</em>. When a worm enters a ring, the trap rapidly constricts so that the worm cannot move away, and the fungus then consumes the worm. The size of the imaged area is 0.7mm x 0.9mm. <Br><Br> This video was obtained with a polychromatic polarizing microscope (PPM) in white light that shows the polychromatic birefringent image with hue corresponding to the slow axis orientation. More information about PPM can be found in the <em>Scientific Reports</em> paper <a href="">“Polychromatic Polarization Microscope: Bringing Colors to a Colorless World”</a> by Shribak. 1/27/2023 9:47:31 PM1/27/2023 9:47:31 PMType    Name    Media Type    File Size    Modified Celegans in Fungus Image    Thumbnail 670 KB 1/27/2023 4:37 PM Bigler, Abbey (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{0F0A87C1-A526-4B01-B302-2C04F7127B77}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3252517Green and yellow fluorescence mark the processes and cell bodies of some <i>C. elegans</i> neurons. Researchers have found that the strategies used by this tiny roundworm to control its motions are remarkably similar to those used by the human brain to command movement of our body parts. From a November 2011 University of Michigan <a href= target="_blank">news release</a>.12/22/2020 4:35:10 PM12/22/2020 4:35:10 PMType    Name    Media Type    File Size    Modified Round_worm    High 2774 KB 6/3/2016 3:25 PM aamishral2 (NIH/NIGMS) [C Green and yellow fluorescence mark the STS_ListItem_DocumentLibrary{7A2F35B4-8E5E-4118-98BE-7AE80AC58462}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
7004359777Protein kinases—enzymes that add phosphate groups to molecules—are cancer chemotherapy targets because they play significant roles in almost all aspects of cell function, are tightly regulated, and contribute to the development of cancer and other diseases if any alterations to their regulation occur. Genetic abnormalities affecting the c-Abl tyrosine kinase are linked to chronic myelogenous leukemia, a cancer of immature cells in the bone marrow. In the noncancerous form of the protein, binding of a myristoyl group to the kinase domain inhibits the activity of the protein until it is needed (top left shows the inactive form, top right shows the open and active form). The cancerous variant of the protein, called Bcr-Abl, lacks this autoinhibitory myristoyl group and is continually active (bottom). ATP is shown in green bound in the active site of the kinase. <Br><Br> Find these in the RCSB Protein Data Bank: <a href="">c-Abl tyrosine kinase and regulatory domains</a> (PDB entry 1OPL) and <a href="">F-actin binding domain</a> (PDB entry 1ZZP). 2/12/2024 9:07:10 PM2/12/2024 9:07:10 PMType    Name    Media Type    File Size    Modified bcr-abl_M    Medium 149 KB 2/5/2024 8:29 AM Crowley, Rachel (NIH/NIGMS) [E In the noncancerous form of the STS_ListItem_DocumentLibrary{5A8F2830-6D55-4A9A-AB75-D62F62FCEE45}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2747844This video shows an instance of abnormal mitosis where chromosomes are late to align. The video demonstrates the spindle checkpoint in action: just one unaligned chromosome can delay anaphase and the completion of mitosis. The cells shown are S3 tissue cultured cells from <i>Xenopus laevis</i>, African clawed frog.8/18/2020 7:49:01 PM8/18/2020 7:49:01 PMType    Name    Media Type    File Size    Modified 2747_Cell_division_with_late_aligning_chromosomes_S    Low 62 KB 3/29/2019 10:58 AM Constantinides, Stephen STS_ListItem_DocumentLibrary{FD7DD0B5-4B32-4B66-BEE4-BB5168CB81FD}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3359870The receptor is shown bound to an antagonist, JDTic.12/23/2020 5:42:55 PM12/23/2020 5:42:55 PMType    Name    Media Type    File Size    Modified OPRK1_1300x1500_yelgreen_S    Low 57 KB 9/14/2016 11:37 AM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{946AAFF8-EC7E-424A-9FD3-5CBCB51E122F}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3406941Phenylalanine tRNA showing the anticodon (yellow) and the amino acid, phenylalanine (blue and red spheres). The structure of phenylalanine tRNA is described in this journal article: Kristensen O, Reshetnikova L, Nissen P, Siboska G, Thirup S, Nyborg J. FEBS Lett. 1996 Dec 9;399(1-2):59-62.12/23/2020 8:47:36 PM12/23/2020 8:47:36 PMType    Name    Media Type    File Size    Modified -tRNAPhe-highres_S    Low 37 KB 9/14/2016 11:42 AM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{EF0971C4-B0FB-4781-9F31-720C0414208A}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
65191059During cell division, cells physically divide after separating their genetic material to create two daughter cells that are genetically identical to the parent cell. This process is important so that new cells can grow and develop. In this image, a human fibroblast cell—a type of connective tissue cell that plays a key role in wound healing and tissue repair—is dividing into two daughter cells. A cell protein called actin appears gray, the myosin II (part of the family of motor proteins responsible for muscle contractions) appears green, and DNA appears magenta. 12/22/2020 4:11:34 PM12/22/2020 4:11:34 PMType    Name    Media Type    File Size    Modified Fibroblast Division_HIghRes    High 3066 KB 11/6/2019 10:20 AM Harris, Donald (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{D58E532F-7578-4EC5-8E98-64840654F119}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2784722Cytoplasmic linker protein (CLIP)-170 is a microtubule plus-end-tracking protein that regulates microtubule dynamics and links microtubule ends to different intracellular structures. In this movie, the gene for CLIP-170 has been fused with green fluorescent protein (GFP). When the protein is expressed in cells, the activities can be monitored in real time. Here, you can see CLIP-170 streaming towards the edges of the cell.9/4/2020 7:36:43 PM9/4/2020 7:36:43 PMType    Name    Media Type    File Size    Modified 2784_Microtubule_dynamics_in_real_time_S    Low 61 KB 3/29/2019 10:52 AM Constantinides, Stephen (NIH/NIGMS STS_ListItem_DocumentLibrary{4781051C-2EC7-46D6-95BC-529D28314966}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
68011259A macrophage—a type of immune cell that engulfs invaders—“eats” and is activated by a “two-faced” Janus particle. The particle is called “two-faced” because each of its two hemispheres is coated with a different type of molecule, shown here in red and cyan. During macrophage activation, a transcription factor tagged with a green fluorescence protein (NF-κB) gradually moves from the cell’s cytoplasm into its nucleus and causes DNA transcription. The distribution of molecules on “two-faced” Janus particles can be altered to control the activation of immune cells. Details on this “geometric manipulation” strategy can be found in the <em> Proceedings of the National Academy of Sciences</em> paper <a href="">"Geometrical reorganization of Dectin-1 and TLR2 on single phagosomes alters their synergistic immune signaling" </a> by Li et al. and the <em> Scientific Reports</em> paper<a href=""> "Spatial organization of FcγR and TLR2/1 on phagosome membranes differentially regulates their synergistic and inhibitory receptor crosstalk"</a> by Li et al. This video was captured using epi-fluorescence microscopy. <Br><Br>Related to video <a href="">6800</a>.8/18/2023 12:40:34 PM8/18/2023 12:40:34 PMType    Name    Media Type    File Size    Modified Macrophage activation-H    High 20221 KB 1/21/2022 2:50 PM Dolan, Lauren (NIH/NIGMS) [C Here is the link to a STS_ListItem_DocumentLibrary{31BAA0E0-226C-4A0C-84A7-8C772C0B3749}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
25461013Meiosis is the process whereby a cell reduces its chromosomes from diploid to haploid in creating eggs or sperm. Featured in <a href= target="_blank"><i>The New Genetics</i></a>.3/4/2022 7:45:44 PM3/4/2022 7:45:44 PMType    Name    Media Type    File Size    Modified Meiosis_with_labels_M    Medium 237 KB 6/3/2016 3:13 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{B2BF9925-C8E0-4844-A56B-BF8C2147EAAF}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131