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23253213In 2006, scientists developed an optical microscopy technique enabling them to clearly see individual molecules within cells. In 2007, they took the technique, abbreviated STORM, a step further. They identified multicolored probes that let them peer into cells and clearly see multiple cellular components at the same time, such as these microtubules (green) and small hollows called clathrin-coated pits (red). Unlike conventional methods, the multicolor STORM technique produces a crisp and high resolution picture. A sharper view of how cellular components interact will likely help scientists answer some longstanding questions about cell biology. Featured in the October 17, 2007, issue of <a href=http://publications.nigms.nih.gov/biobeat/07-10-17/#1 target="_blank"><em>Biomedical Beat</em></a>.10/29/2020 2:02:16 PM10/29/2020 2:02:16 PMIn 2006, scientists developed an optical microscopy technique enabling them to clearly see individual molecules within Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1940https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{76D31C7C-D8E7-4BC2-BCAB-8D4B7465DE4F}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
36003711A mouse's fat cells (red) are shown surrounded by a network of blood vessels (green). Fat cells store and release energy, protect organs and nerve tissues, insulate us from the cold and help us absorb important vitamins. This image is part of the Life: Magnified collection, which was displayed in the Gateway Gallery at Washington Dulles International Airport June 3, 2014, to January 21, 2015. To see all 46 images in this exhibit, go to https://www.nigms.nih.gov/education/life-magnified/Pages/default.aspx.11/22/2022 8:43:42 PM11/22/2022 8:43:42 PMType    Name    Media Type    File Size    Modified 7_right_Fat_cells_and_blood_vessel_34in_Malide_H    High 4848 KB 10/19/2020 3:10 AM Harris, Donald (NIH STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1440https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{F5343960-E864-40C3-A794-C1F7F1C9CD4F}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
67903813Two cells over a 2-hour period. The one on the bottom left goes through programmed cell death, also known as apoptosis. The one on the top right goes through cell division, also called mitosis. This video was captured using a confocal microscope. 12/27/2021 4:57:37 PM12/27/2021 4:57:37 PMType    Name    Media Type    File Size    Modified Technique: Structured Illumination Microscopy (SIM) Video: DNA during cell death and Technique: Confocal STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1540https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{CC8B5303-F2D9-4014-B9B9-68597C41C367}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
68063890The two large, central, round shapes are ovaries from a typical fruit fly (<em>Drosophila melanogaster</em>). The small butterfly-like structures surrounding them are fruit fly ovaries where researchers suppressed the expression of a gene that controls microtubule polymerization and is necessary for normal development. This image was captured using a confocal laser scanning microscope. <Br><Br> Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6807">6807</a>. 1/21/2022 3:55:03 PM1/21/2022 3:55:03 PMType    Name    Media Type    File Size    Modified Wild-type and mutant fruit fly ovaries_M    Medium 119 KB 2/11/2022 1:44 PM Dolan, Lauren (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1050https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{1CE96574-AF64-43B2-8987-EDADC4899FE7}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
27023455A combo of protein structures determined experimentally and computationally shows us the complete metabolic network of a heat-loving bacterium.8/6/2020 4:36:05 PM8/6/2020 4:36:05 PMType    Name    Media Type    File Size    Modified 2702_Thermotoga_maritima_and_its_metabolic_network_T    Thumbnail 97 KB 3/29/2019 11:00 AM Constantinides STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1230https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{8BCB0A5C-8081-41B2-AEC1-62DCCD78EE99}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
34773698This image is a computer-generated model of the approximately 4.2 million atoms of the HIV capsid, the shell that contains the virus' genetic material. Scientists determined the exact structure of the capsid and the proteins that it's made of using a variety of imaging techniques and analyses. They then entered these data into a supercomputer that produced the atomic-level image of the capsid. This structural information could be used for developing drugs that target the capsid, possibly leading to more effective therapies11/14/2023 1:23:33 PM11/14/2023 1:23:33 PMType    Name    Media Type    File Size    Modified and the proteins that it's made of using a variety of imaging techniques and analyses They then entered these data into a STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1840https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{4475C347-ACA7-4D71-B1A5-B70167940ACF}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
67893812Two mouse fibroblasts, one of the most common types of cells in mammalian connective tissue. They play a key role in wound healing and tissue repair. This image was captured using structured illumination microscopy. 12/27/2021 4:20:11 PM12/27/2021 4:20:11 PMType    Name    Media Type    File Size    Modified Technique: Structured Illumination Microscopy (SIM) Video: DNA during cell death and Technique: Confocal STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx2340https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{911FF0EB-C528-450C-93F7-22CEEFA45FCF}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
57933747What looks like the gossamer wings of a butterfly is actually the retina of a mouse, delicately snipped to lay flat and sparkling with fluorescent molecules. The image is from a research project investigating the promise of gene therapy for glaucoma. It was created at an NIGMS-funded advanced microscopy facility that develops technology for imaging across many scales, from whole organisms to cells to individual molecules. <BR><BR> The ability to obtain high-resolution imaging of tissue as large as whole mouse retinas was made possible by a technique called large-scale mosaic confocal microscopy, which was pioneered by the NIGMS-funded National Center for Microscopy and Imaging Research. The technique is similar to Google Earth in that it computationally stitches together many small, high-resolution images. <BR><BR> More details: <BR><BR> Glaucoma is a progressive eye disease and the leading cause of irreversible blindness. It is characterized by the death of neurons in the retina called retinal ganglion cells. A number of studies over the past decade suggest that targeting these cells with gene therapy designed to prevent their death might slow the progression of glaucoma. <BR><BR> This study is investigating whether a non-disease-causing virus (adeno-associated virus serotype 2) can effectively deliver genes to retinal ganglion cells. The researchers introduced into the virus a gene for green fluorescent protein (GFP) so they could visualize how well the virus transduced the cells. <BR><BR> Two months after viral delivery of the fluorescent vector to the eyes of 7-month-old mice, the researchers examined the entire retinas of the subjects under a microscope. The ability to obtain high-resolution imaging of tissue as large as whole mouse retinas was made possible by a technique called large-scale mosaic confocal microscopy, which was pioneered by the NIGMS-funded National Center for Microscopy and Imaging Research. The technique is similar to Google Earth in that it computationally stitches together many small, high-resolution images. <BR><BR> The researchers observed GFP expression (yellow) in all parts of the retinal ganglion cells (blue), including the soma, axons and dendritic tree. These results suggest that a viral delivery system could deliver therapeutic genes to retinal ganglion cells for treating glaucoma and related diseases. <BR><BR> EQUIPMENT: Olympus FluoView™ FV1000 Confocal Microscope. Fluorophores: green fluorescent protein and Alexa Fluor 568. Non-glaucomatous DBA/2J-Gpnmb+ mice. <BR><BR> Reflecting on the work, the lead researcher [Keunyoung (“Christine”) Kim] says: “It is amazing to see intricate and artistically organized microscopic structures. … I encountered an entirely new world invisible to the naked eye—a galaxy of infinite secrets and endless potential for discovery.” 7/19/2023 8:25:17 PM7/19/2023 8:25:17 PMby a technique called large-scale mosaic confocal microscopy, which was pioneered by the The technique is similar to Google Earth in that it computationally stitches together many STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1430https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{E2CC74AB-01A0-4BBC-964B-CF278FF727BA}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
23203208How far and fast an infectious disease spreads across a community depends on many factors, including transportation. These U.S. maps, developed as part of an international study to simulate and analyze disease spread, chart daily commuting patterns. They show where commuters live (top) and where they travel for work (bottom). Green represents the fewest number of people whereas orange, brown, and white depict the most. Such information enables researchers and policymakers to visualize how an outbreak in one area can spread quickly across a geographic region. Featured in the August 15, 2007, issue of <a href=http://publications.nigms.nih.gov/biobeat/07-08-15/#1 target="_blank"><em>Biomedical Beat</em></a>.10/29/2020 1:48:39 PM10/29/2020 1:48:39 PMType    Name    Media Type    File Size    Modified 2320_mappingdisease1_S    Low 134 KB 3/29/2019 1:49 PM Constantinides, Stephen (NIH Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1540https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{DCC53428-D85F-4B28-AE7A-1BDF3A1498B7}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
33393354This is a super-resolution LM image taken by Hiro Hakozaki and Masa Hoshijima of NCMIR. The image contains highlighted calcium channels in cardiac muscle using a technique called dSTORM. The microscope used in the NCMIR lab was built by Hiro Hakozaki.12/23/2020 5:37:10 PM12/23/2020 5:37:10 PMType    Name    Media Type    File Size    Modified dSTORM_Cardiac1_L    Low 131 KB 6/3/2016 3:27 PM aamishral2 (NIH/NIGMS) [C Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1230https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{0E46207E-187E-4107-BAE4-5B30FD3E8DE2}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
69323792An axolotl—a type of salamander—that has been genetically modified so that its developing nervous system glows purple and its Schwann cell nuclei appear light blue. Schwann cells insulate and provide nutrients to peripheral nerve cells. Researchers often study axolotls for their extensive regenerative abilities. They can regrow tails, limbs, spinal cords, brains, and more. The researcher who took this image focuses on the role of the peripheral nervous system during limb regeneration. <Br><Br> This image was captured using a stereo microscope. <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6927">6927</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6928">6928</a>. 3/28/2023 7:22:11 PM3/28/2023 7:22:11 PMType    Name    Media Type    File Size    Modified Purple Axolotl_M    Medium 92 KB 3/28/2023 2:13 PM Bigler, Abbey (NIH/NIGMS) [C Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1540https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{C3BEC74E-68A6-4729-9CC3-F59BF6253164}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
69653901As this cell was undergoing cell division, it was imaged with two microscopy techniques: differential interference contrast (DIC) and confocal. The DIC view appears in blue and shows the entire cell. The confocal view appears in pink and shows the chromosomes.1/27/2023 9:51:37 PM1/27/2023 9:51:37 PMType    Name    Media Type    File Size    Modified An oblong blue shape with a with two different microscopy techniques: differential interference contrast (DIC) and STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx2160https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{CCDAC100-8DE1-4D58-8378-2F585CC18A16}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
68083892Two fruit fly (<em>Drosophila melanogaster</em>) larvae brains with neurons expressing fluorescently tagged tubulin protein. Tubulin makes up strong, hollow fibers called microtubules that play important roles in neuron growth and migration during brain development. This image was captured using confocal microscopy, and the color indicates the position of the neurons within the brain.1/20/2022 7:49:11 PM1/20/2022 7:49:11 PMType    Name    Media Type    File Size    Modified Drosophila 3rd instar larval brain expressing neuronal tubulin-Wen Lu and Vladimir I. Gelfand_M    Medium 175 KB STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1230https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{8643DBC3-712E-4596-B178-AE3E38631BAB}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
69313791Various views of a mouse brain that was genetically modified so that subpopulations of its neurons glow. Researchers often study mice because they share many genes with people and can shed light on biological processes, development, and diseases in humans. <Br><Br> This video was captured using a light sheet microscope. <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6929">6929</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6930">6930</a>. 3/28/2023 7:25:52 PM3/28/2023 7:25:52 PMType    Name    Media Type    File Size    Modified MouseBrainThumbnail    Thumbnail 251 KB 3/28/2023 1:42 PM Bigler, Abbey (NIH/NIGMS) [C Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1240https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{E8BA1CD7-FBAD-470A-8536-1897FD575924}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
69333793Various views of a zebrafish head with blood vessels shown in purple. Researchers often study zebrafish because they share many genes with humans, grow and reproduce quickly, and have see-through eggs and embryos, which make it easy to study early stages of development. <Br><Br> This video was captured using a light sheet microscope. <Br><Br> Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6934">6934</a>. 3/28/2023 7:28:33 PM3/28/2023 7:28:33 PMType    Name    Media Type    File Size    Modified Zebrafish    High 79865 KB 3/28/2023 2:27 PM Bigler, Abbey (NIH/NIGMS) [C Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1540https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{51C6DED5-0B9A-4BCB-BB8C-2DEF96D5D9F7}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
69283788Axolotls—a type of salamander—that have been genetically modified so that various parts of their nervous systems glow purple and green. Researchers often study axolotls for their extensive regenerative abilities. They can regrow tails, limbs, spinal cords, brains, and more. The researcher who took this image focuses on the role of the peripheral nervous system during limb regeneration. <Br><Br> This image was captured using a stereo microscope. <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6927">6927</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6932">6932</a>. 3/28/2023 8:07:20 PM3/28/2023 8:07:20 PMType    Name    Media Type    File Size    Modified Multiple Axolotls_M    Medium 191 KB 3/28/2023 1:17 PM Bigler, Abbey (NIH/NIGMS) [C Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1040https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{808924E1-6D1E-4693-AF54-9CFAB370BB78}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
67523771The white circle in this image is a Petri dish, named for its inventor, Julius Richard Petri. These dishes are one of the most common pieces of equipment in biology labs, where researchers use them to grow cells. 3/24/2021 4:29:32 PM3/24/2021 4:29:32 PMType    Name    Media Type    File Size    Modified Ghosh et al_SciPak multimedia 2_2.24.2021_M    Medium 197 KB 3/24/2021 12:30 PM Walter Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1540https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{9E398F6D-39AB-4C53-9AC1-2968D86BF556}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
35563639Luciferase-based imaging enables visualization and quantification of internal organs and transplanted cells in live adult zebrafish. In this image, a cardiac muscle-restricted promoter drives firefly luciferase expression. Lateral (Top) and overhead views (Bottom) are shown.10/5/2020 5:20:22 AM10/5/2020 5:20:22 AMType    Name    Media Type    File Size    Modified Poss-zebrafish-01    High 416 KB 6/3/2016 3:31 PM aamishral2 (NIH/NIGMS) [C br>For imagery of the overhead STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1130https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{3D1F01B8-728A-4F3D-B381-CF2B50DEAA2C}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
68913819Microtubules in African green monkey cells. Microtubules are strong, hollow fibers that provide cells with structural support. Here, the microtubules have been color-coded based on their distance from the microscope lens: purple is closest to the lens, and yellow is farthest away. This image was captured using Stochastic Optical Reconstruction Microscopy (STORM). <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6889">6889</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6890">6890</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6892">6892</a>. 4/4/2022 4:10:02 PM4/4/2022 4:10:02 PMType    Name    Media Type    File Size    Modified MicrotubulesinMonkeyCells_M    Medium 240 KB 4/4/2022 10:39 AM Bigler, Abbey (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1240https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{1F39E3DF-F3C9-48A9-9597-492A967EA195}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
68893857Lysosomes (yellow) and detyrosinated microtubules (light blue). Lysosomes are bubblelike organelles that take in molecules and use enzymes to break them down. Microtubules are strong, hollow fibers that provide structural support to cells. The researchers who took this image found that in epithelial cells, detyrosinated microtubules are a small subset of fibers, and they concentrate lysosomes around themselves. This image was captured using Stochastic Optical Reconstruction Microscopy (STORM). <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6890">6890</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6891">6891</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6892">6892</a>.4/4/2023 8:32:04 PM4/4/2023 8:32:04 PMType    Name    Media Type    File Size    Modified Lysosomes_M    Medium 128 KB 4/1/2022 4:38 PM Bigler, Abbey (NIH/NIGMS) [C Let me know if this is good or if STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1030https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{61D1D731-2E41-4381-B686-1D02186676AD}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
69303790A mouse brain that was genetically modified so that subpopulations of its neurons glow. Researchers often study mice because they share many genes with people and can shed light on biological processes, development, and diseases in humans. <Br><Br> This image was captured using a light sheet microscope. <Br><Br> Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6929">6929</a> and video <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6931">6931</a>. 3/28/2023 7:24:56 PM3/28/2023 7:24:56 PMType    Name    Media Type    File Size    Modified Mouse Brain_M    Medium 916 KB 3/28/2023 1:33 PM Bigler, Abbey (NIH/NIGMS) [C Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1040https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{EDEB926E-99D7-43B0-9376-354FF89CE847}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
69343896A zebrafish head with blood vessels shown in purple. Researchers often study zebrafish because they share many genes with humans, grow and reproduce quickly, and have see-through eggs and embryos, which make it easy to study early stages of development. <Br><Br> This image was captured using a light sheet microscope. <Br><Br> Related to video <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6933">6933</a>. 3/28/2023 7:29:10 PM3/28/2023 7:29:10 PMType    Name    Media Type    File Size    Modified Zebrafish Head_M    Medium 223 KB 3/28/2023 2:34 PM Bigler, Abbey (NIH/NIGMS) [C Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1440https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{219F8BBA-541A-415A-9069-43E8563AA932}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
27543277This simulation of myosin V binding to actin was created using the software tool Protein Mechanica. With Protein Mechanica, researchers can construct models using information from a variety of sources: crystallography, cryo-EM, secondary structure descriptions, as well as user-defined solid shapes, such as spheres and cylinders. The goal is to enable experimentalists to quickly and easily simulate how different parts of a molecule interact.8/21/2020 6:10:42 PM8/21/2020 6:10:42 PMType    Name    Media Type    File Size    Modified mv_dimer_T    Thumbnail 4 KB 6/3/2016 3:17 PM aamishral2 (NIH/NIGMS) [C Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1430https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{0B867130-6ACF-4FC5-A90B-30B55CA4182D}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
68013783A macrophage—a type of immune cell that engulfs invaders—“eats” and is activated by a “two-faced” Janus particle. The particle is called “two-faced” because each of its two hemispheres is coated with a different type of molecule, shown here in red and cyan. During macrophage activation, a transcription factor tagged with a green fluorescence protein (NF-κB) gradually moves from the cell’s cytoplasm into its nucleus and causes DNA transcription. The distribution of molecules on “two-faced” Janus particles can be altered to control the activation of immune cells. Details on this “geometric manipulation” strategy can be found in the <em> Proceedings of the National Academy of Sciences</em> paper <a href="https://www.pnas.org/content/116/50/25106.long">"Geometrical reorganization of Dectin-1 and TLR2 on single phagosomes alters their synergistic immune signaling" </a> by Li et al. and the <em> Scientific Reports</em> paper<a href="https://www.nature.com/articles/s41598-021-92910-9"> "Spatial organization of FcγR and TLR2/1 on phagosome membranes differentially regulates their synergistic and inhibitory receptor crosstalk"</a> by Li et al. This video was captured using epi-fluorescence microscopy. <Br><Br>Related to video <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6800">6800</a>.8/18/2023 12:40:34 PM8/18/2023 12:40:34 PMType    Name    Media Type    File Size    Modified Macrophage activation-H    High 20221 KB 1/21/2022 2:50 PM Dolan, Lauren (NIH/NIGMS) [C Here is the link to a STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx830https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{31BAA0E0-226C-4A0C-84A7-8C772C0B3749}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
69623898A <em>Trigonium</em> diatom imaged by a quantitative orientation-independent differential interference contrast (OI-DIC) microscope. Diatoms are single-celled photosynthetic algae with mineralized cell walls that contain silica and provide protection and support. These organisms form an important part of the plankton at the base of the marine and freshwater food chains. The width of this image is 90 μm. <Br><Br> More information about the microscopy that produced this image can be found in the <em>Journal of Microscopy</em> paper <a href="https://onlinelibrary.wiley.com/doi/10.1111/jmi.12682/">“An Orientation-Independent DIC Microscope Allows High Resolution Imaging of Epithelial Cell Migration and Wound Healing in a Cnidarian Model”</a> by Malamy and Shribak. 1/27/2023 9:46:30 PM1/27/2023 9:46:30 PMType    Name    Media Type    File Size    Modified Trigonium_M    Medium 692 KB 1/27/2023 4:29 PM Bigler, Abbey (NIH/NIGMS) [C The image width is 90 μm STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx2560https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{F78335F9-FB37-4883-9939-AEB00AE242F9}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
67503769These microscopic roundworms, called <i>Caenorhabditis elegans</i>, lack eyes and the opsin proteins used by visual systems to detect colors. However, researchers found that the worms can still sense the color of light in a way that enables them to avoid pigmented toxins made by bacteria. This image was captured using a stereo microscope.3/24/2021 5:44:57 PM3/24/2021 5:44:57 PMType    Name    Media Type    File Size    Modified Ghosh et al_SciPak multimedia 1_2.24.2021_M    Medium 42 KB 3/24/2021 11:16 AM Walter, Taylor (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1440https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{760D483D-C76B-4606-BCD1-4887E3807BC8}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
67513770This Petri dish contains microscopic roundworms called <i>Caenorhabditis elegans</i>. Researchers used these particular worms to study how <i>C. elegans</i> senses the color of light in its environment. 3/24/2021 5:46:13 PM3/24/2021 5:46:13 PMType    Name    Media Type    File Size    Modified Ghosh et al_SciPak multimedia 3_2.24.2021_M    Medium 162 KB 3/24/2021 12:21 PM Walter Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx2750https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{C00999DD-94AD-4601-AB49-4C393FEDCF73}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
68923820Microtubules (magenta) and tau protein (light blue) in a cell model of tauopathy. Researchers believe that tauopathy—the aggregation of tau protein—plays a role in Alzheimer’s disease and other neurodegenerative diseases. This image was captured using Stochastic Optical Reconstruction Microscopy (STORM). <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6889">6889</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6890">6890</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6891">6891</a>.4/4/2023 8:31:39 PM4/4/2023 8:31:39 PMType    Name    Media Type    File Size    Modified MicrotubulesandTau_S    Low 27 KB 4/4/2022 10:58 AM Bigler, Abbey (NIH/NIGMS) [C Let me know if this is good STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1440https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{DE00583D-B9CB-4665-84E3-2261F1F17414}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
68873855The nucleus of a human fibroblast cell with chromatin—a substance made up of DNA and proteins—shown in various colors. Fibroblasts are one of the most common types of cells in mammalian connective tissue, and they play a key role in wound healing and tissue repair. This image was captured using Stochastic Optical Reconstruction Microscopy (STORM). <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6888">6888</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6893">6893</a>.4/4/2022 3:59:29 PM4/4/2022 3:59:29 PMType    Name    Media Type    File Size    Modified Fibroblast2_S    Low 23 KB 4/4/2022 10:51 AM Bigler, Abbey (NIH/NIGMS) [C Let me know if this is good or if STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx930https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{635C6863-170A-4012-9511-EDA350373D39}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
23173022These colorful, computer-generated ribbons show the backbone of a molecule that glows a fluorescent red. The molecule, called mStrawberry, was created by chemists based on a protein found in the ruddy lips of a coral. Scientists use the synthetic molecule and other "fruity" ones like it as a dye to mark and study cell structures. Featured in the April 18, 2007, issue of <a href=http://publications.nigms.nih.gov/biobeat/07-04-18/#1 target="_blank"><em>Biomedical Beat</em></a>.10/29/2020 1:18:41 PM10/29/2020 1:18:41 PMType    Name    Media Type    File Size    Modified 2317_FruitDyes_S    Low 83 KB 3/29/2019 1:51 PM Constantinides, Stephen (NIH/NIGMS) [C Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1130https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{62278375-2AA3-4063-84BB-497CE6085362}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
68933821The nucleus of a degenerating human tendon cell, also known as a tenocyte. It has been color-coded based on the density of chromatin—a substance made up of DNA and proteins. Areas of low chromatin density are shown in blue, and areas of high chromatin density are shown in red. This image was captured using Stochastic Optical Reconstruction Microscopy (STORM). <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6887">6887</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6888">6888</a>.4/4/2023 8:31:20 PM4/4/2023 8:31:20 PMType    Name    Media Type    File Size    Modified Tenocyte_S    Low 18 KB 4/4/2022 11:00 AM Bigler, Abbey (NIH/NIGMS) [C Let me know if this is good or if you STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx2040https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{5D92D72C-7BD8-40CF-9C24-97829634C429}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
68863854Neutrophil-like cells (blue) in a microfluidic chip preferentially migrating toward LTB4 over fMLP. A neutrophil is a type of white blood cell that is part of the immune system and helps the body fight infection. Both LTB4 and fMLP are molecules involved in immune response. Microfluidic chips are small devices containing microscopic channels, and they are used in a range of applications, from basic research on cells to pathogen detection. The scale bar in this video is 500μm.4/1/2022 8:13:40 PM4/1/2022 8:13:40 PMType    Name    Media Type    File Size    Modified CellMigration    High 3903 KB 4/4/2022 10:32 AM Bigler, Abbey (NIH/NIGMS) [C The scale bar in this video is 500μm STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1040https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{2FB4E3AD-9AC0-4E23-9872-B4D8B3D37E23}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
23643151This slide shows the technologies that the Joint Center for Structural Genomics developed for going from gene to structure and how the technologies have been integrated into a high-throughput pipeline, including all of the steps from target selection, parallel expression, protein purification, automated crystallization trials, automated crystal screening, structure determination, validation, and publication.10/29/2020 4:14:36 PM10/29/2020 4:14:36 PMType    Name    Media Type    File Size    Modified hi_JCSG_HT_fig1_L    Low 48 KB 6/3/2016 3:09 PM aamishral2 (NIH/NIGMS) [C Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1230https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{CB7FC174-4D2A-4475-86DE-2E0C2E11209E}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
58683619This image results from a research project to visualize which regions of the adult fruit fly (Drosophila) brain derive from each neural stem cell. First, researchers collected several thousand fruit fly larvae and fluorescently stained a random stem cell in the brain of each. The idea was to create a population of larvae in which each of the 100 or so neural stem cells was labeled at least once. When the larvae grew to adults, the researchers examined the flies’ brains using confocal microscopy. </br>With this technique, the part of a fly’s brain that derived from a single, labeled stem cell “lights up.” The scientists photographed each brain and digitally colorized its lit-up area. By combining thousands of such photos, they created a 3-dimensional, color-coded map that shows which part of the Drosophila brain comes from each of its ~100 neural stem cells. In other words, each colored region shows which neurons are the progeny or “clones” of a single stem cell. This work established a hierarchical structure as well as nomenclature for the neurons in the Drosophila brain. Further research will relate functions to structures of the brain. Related to image <a href="/Pages/DetailPage.aspx?imageID2=5838">5838</a> and video<a href="/Pages/DetailPage.aspx?imageID2=5843"> 5843</a>.5/13/2022 12:37:47 PM5/13/2022 12:37:47 PMType    Name    Media Type    File Size    Modified The idea was to create a br>With this technique, the part of a fly’s brain that derived from a single, labeled stem STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1140https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{EFD1667C-BB60-4249-BF4D-7D58C39BE735}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
58383684This image results from a research project to visualize which regions of the adult fruit fly (Drosophila) brain derive from each neural stem cell. First, researchers collected several thousand fruit fly larvae and fluorescently stained a random stem cell in the brain of each. The idea was to create a population of larvae in which each of the 100 or so neural stem cells was labeled at least once. When the larvae grew to adults, the researchers examined the flies’ brains using confocal microscopy. With this technique, the part of a fly’s brain that derived from a single, labeled stem cell “lights up.” The scientists photographed each brain and digitally colorized its lit-up area. By combining thousands of such photos, they created a 3-dimensional, color-coded map that shows which part of the Drosophila brain comes from each of its ~100 neural stem cells. In other words, each colored region shows which neurons are the progeny or “clones” of a single stem cell. This work established a hierarchical structure as well as nomenclature for the neurons in the Drosophila brain. Further research will relate functions to structures of the brain. Related to image <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=3808">5868</a> and video<a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=3749"> 5843</a> 5/13/2022 12:38:45 PM5/13/2022 12:38:45 PMType    Name    Media Type    File Size    Modified The idea was to create a With this technique, the part of a fly’s brain that derived from a single, labeled stem STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1240https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{E35C7327-EDA4-46DF-B3D4-A0F7CF02CCC0}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
69023826An <em> Arachnoidiscus</em> diatom with a diameter of 190µm. Diatoms are microscopic algae that have cell walls made of silica, which is the strongest known biological material relative to its density. In <em> Arachnoidiscus</em>, the cell wall is a radially symmetric pillbox-like shell composed of overlapping halves that contain intricate and delicate patterns. Sometimes, <em> Arachnoidiscus</em> is called “a wheel of glass.” <Br><Br> This image was taken with the orientation-independent differential interference contrast microscope. 7/13/2022 8:00:33 PM7/13/2022 8:00:33 PMType    Name    Media Type    File Size    Modified Fourth of July_S    Low 40 KB 7/13/2022 4:09 PM Bigler, Abbey (NIH/NIGMS) [C Fourth of July    High 213 KB STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1240https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{061D17CD-3B20-4996-B7BC-CC797BDA0A6D}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
68113895A fruit fly (<em>Drosophila melanogaster</em>) egg chamber with microtubules shown in green and actin filaments shown in red. Egg chambers are multicellular structures in fruit flies ovaries that each give rise to a single egg. Microtubules and actin filaments give the chambers structure and shape. This image was captured using a confocal microscope. <Br><Br> More information on the research that produced this image can be found in the <em> Current Biology</em> paper <a href="https://www.cell.com/current-biology/fulltext/S0960-9822(21)00669-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0960982221006692%3Fshowall%3Dtrue">"Gatekeeper function for Short stop at the ring canals of the <em>Drosophila</em> ovary"</a> by Lu et al.2/18/2022 6:32:46 PM2/18/2022 6:32:46 PMType    Name    Media Type    File Size    Modified 6811_M    Medium 58 KB 2/11/2022 2:24 PM Crowley, Rachel (NIH/NIGMS) [E Br><Br> More information on the research that produced this image can be found in the <em> Current Biology STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1540https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{A854D3BF-9D10-4F4C-858F-D399C6B8FFFD}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
37553605The illustration shows the capsid of human immunodeficiency virus (HIV) whose molecular features were resolved with cryo-electron microscopy (cryo-EM). On the left, the HIV capsid is "naked," a state in which it would be easily detected by and removed from cells. However, as shown on the right, when the viral capsid binds to and is covered with a host protein, called cyclophilin A (shown in red), it evades detection and enters and invades the human cell to use it to establish an infection. To learn more about how cyclophilin A helps HIV infect cells and how scientists used cryo-EM to find out the mechanism by which the HIV capsid attaches to cyclophilin A, <a href="https://news.illinois.edu/blog/view/6367/335013">see this news release by the University of Illinois</a>. A study reporting these findings was published in the journal <a href="http://www.nature.com/ncomms/2016/160304/ncomms10714/full/ncomms10714.html"><i>Nature Communications</i></a>.12/17/2020 6:19:59 PM12/17/2020 6:19:59 PMType    Name    Media Type    File Size    Modified HIV capsid square crop    Thumbnail 152 KB 10/13/2016 12:57 PM Machalek, Alisa (NIH/NIAMS) [E STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx840https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{0E29D964-8A3C-4D5E-8F31-BC20B251F865}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
69693860Multicellular yeast called snowflake yeast that researchers created through many generations of directed evolution from unicellular yeast. Stained cell membranes (green) and cell walls (red) reveal the connections between cells. Younger cells take up more cell membrane stain, while older cells take up more cell wall stain, leading to the color differences seen here. This image was captured using spinning disk confocal microscopy. <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6970">6970</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6971">6971</a>.2/6/2023 2:03:47 PM2/6/2023 2:03:47 PMType    Name    Media Type    File Size    Modified Snowflake Yeast 1_S    Low 41 KB 2/3/2023 5:01 PM Bigler, Abbey (NIH/NIGMS) [C Br><Br> I'm more than happy STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1530https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{13BFE02E-5067-4F4E-8F06-F790AF503C2C}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
69703861Multicellular yeast called snowflake yeast that researchers created through many generations of directed evolution from unicellular yeast. Cells are connected to one another by their cell walls, shown in blue. Stained cytoplasm (green) and membranes (magenta) show that the individual cells remain separate. This image was captured using spinning disk confocal microscopy. <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6969">6969</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6971">6971</a>.11/15/2023 1:15:17 PM11/15/2023 1:15:17 PMType    Name    Media Type    File Size    Modified Snowflake Yeast 2_S    Low 56 KB 2/3/2023 5:02 PM Bigler, Abbey (NIH/NIGMS) [C Br><Br> I'm more than happy STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1640https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{6131B071-A4E1-4EAB-9666-CA6A3FAF1CA7}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
35843580This image shows a computer-generated, three-dimensional map of the rotavirus structure. This virus infects humans and other animals and causes severe diarrhea in infants and young children. By the age of five, almost every child in the world has been infected with this virus at least once. Scientists have found a vaccine against rotavirus, so in the United States there are very few fatalities, but in developing countries and in places where the vaccine is unavailable, this virus is responsible for more than 450,000 deaths each year.<Br><Br> The rotavirus comprises three layers: the outer, middle and inner layers. On infection, the outer layer is removed, leaving behind a "double-layered particle." Researchers have studied the structure of this double-layered particle with a transmission electron microscope. Many images of the virus at a magnification of ~50,000x were acquired, and computational analysis was used to combine the individual particle images into a three-dimensional reconstruction. <Br><Br>The image was rendered by Melody Campbell (PhD student at TSRI). Work that led to the 3D map was published in Campbell et al. Movies of ice-embedded particles enhance resolution in electron cryo-microscopy. Structure. 2012;20(11):1823-8. PMCID: PMC3510009. <Br><Br>This image was part of the Life: Magnified collection, which was displayed in the Gateway Gallery at Washington Dulles International Airport June 3, 2014, to January 21, 2015. To see all 46 images in this exhibit, go to https://www.nigms.nih.gov/education/life-magnified/Pages/default.aspx.11/22/2022 8:55:40 PM11/22/2022 8:55:40 PMType    Name    Media Type    File Size    Modified Carragher_Rota_Virus_M    Medium 1505 KB 7/27/2016 10:54 AM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx930https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{38997347-01E8-4B63-97E7-3CD152CD4331}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
68043888<em>Staphylococcus aureus</em> bacteria (blue) on the porous coating of a femoral hip stem used in hip replacement surgery. The relatively rough surface of an implant is a favorable environment for bacteria to attach and grow. This can lead to the development of biofilms, which can cause infections. The researchers who took this image are working to understand where biofilms are likely to develop. This knowledge could support the prevention and treatment of infections. A scanning electron microscope was used to capture this image. <Br><Br>More information on the research that produced this image can be found in the <em>Antibiotics</em> paper<a href="https://www.mdpi.com/2079-6382/10/8/889"> "Free-floating aggregate and single-cell-initiated biofilms of <em>Staphylococcus aureus</em>" </a>by Gupta et al. <Br><Br>Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6803">6803</a> and video <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6805">6805</a>.10/18/2023 2:56:58 PM10/18/2023 2:56:58 PMType    Name    Media Type    File Size    Modified S. aureus in the porous coating of a femoral stem_M    Medium 73 KB 1/20/2022 1:51 PM Crowley, Rachel (NIH STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1740https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{F8EB39E7-349E-48B6-A64F-0CDEEC68BEB6}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
68093893Two fruit fly (<em>Drosophila melanogaster</em>) egg cells, one on each side of the central black line. The colorful swirls show the circular movement of cytoplasm—called ooplasmic streaming—that occurs in late egg cell development in wild-type (right) and mutant (left) oocytes. This image was captured using confocal microscopy. <Br><Br> More information on the research that produced this image can be found in the <em>Journal of Cell Biology</em> paper <a href="https://rupress.org/jcb/article/217/10/3497/120275/Ooplasmic-flow-cooperates-with-transport-and">“Ooplasmic flow cooperates with transport and anchorage in <em>Drosophila</em> oocyte posterior determination”</a> by Lu et al. 1/21/2022 3:52:59 PM1/21/2022 3:52:59 PMType    Name    Media Type    File Size    Modified Drosophila ooplasmic streaming_T    Thumbnail 2 KB 2/11/2022 1:41 PM Crowley, Rachel (NIH/NIGMS) [E STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1240https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{4D253170-106E-4EDF-AE42-322E3351BAE7}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
68073891Fruit fly (<em>Drosophila melanogaster</em>) ovaries with DNA shown in magenta and actin filaments shown in light blue. This image was captured using a confocal laser scanning microscope. <Br><Br> Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6806">6806</a>. 1/21/2022 3:54:37 PM1/21/2022 3:54:37 PMType    Name    Media Type    File Size    Modified 6807_M    Medium 503 KB 2/11/2022 2:22 PM Crowley, Rachel (NIH/NIGMS) [E The image was acquired on a Nikon STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1030https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{D9DE9B13-7DC9-4BB0-AA55-E415609A5F44}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
69013825A 20-µm thick section of mouse midbrain. The nerve cells are transparent and weren’t stained. Instead, the color is generated by interaction of white polarized light with the molecules in the cells and indicates their orientation. <Br><Br>The image was obtained with a polychromatic polarizing microscope that shows the polychromatic birefringent image with hue corresponding to the slow axis orientation. More information about the microscopy that produced this image can be found in the <em>Scientific Reports</em> paper <a href="https://www.nature.com/articles/srep17340/">“Polychromatic Polarization Microscope: Bringing Colors to a Colorless World”</a> by Shribak. 6/30/2022 12:16:01 PM6/30/2022 12:16:01 PMType    Name    Media Type    File Size    Modified Brain Slice_S    Low 10 KB 7/13/2022 4:07 PM Bigler, Abbey (NIH/NIGMS) [C More information about the microscopy that produced this image can be found in STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1140https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{ED8899BF-3F30-4957-A9CB-6F1530901C7A}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
28073283Confocal image showing high levels of the protein vimentin (white) at the edge zone of a quail embryo. Cell nuclei are labeled green. More specifically, this high-magnification (60X) image shows vimentin immunofluorescence in the edge zone (top of image) and inner zone (bottom of image) of a Stage 4 quail blastoderm. Vimentin expression (white) is shown merged with Sytox nuclear labeling (green) at the edge of the blastoderm. A thick vimentin filament runs circumferentially (parallel to the direction of the edge) that appears to delineate the transition between the edge zone and interior zone. Also shown are dense vimentin clusters or foci, which typically appear to be closely associated with edge cell nuclei. This image appeared in a <a href=http://gtresearchnews.gatech.edu/quail-embryo/ target="_blank">March 2011 Georgia Tech news release</a>. An NIGMS grant to Professor Garcia was used to purchase the confocal microscope that collected this image. Related entries: 2808 and 2809.12/22/2020 4:28:11 PM12/22/2020 4:28:11 PMType    Name    Media Type    File Size    Modified vimentin_hires    High 403 KB 6/3/2016 3:18 PM aamishral2 (NIH/NIGMS) [C Also shown are dense vimentin clusters or STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx830https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{ECFC258C-6BEC-4C4F-9998-00CB33ACD7D8}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
68903858Microtubules (magenta) in neurons of the hippocampus, a part of the brain involved in learning and memory. Microtubules are strong, hollow fibers that provide structural support to cells. This image was captured using Stochastic Optical Reconstruction Microscopy (STORM). <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6889">6889</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6891">6891</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6892">6892</a>.4/4/2023 8:30:37 PM4/4/2023 8:30:37 PMType    Name    Media Type    File Size    Modified Microtubules_S    Low 27 KB 4/4/2022 10:57 AM Bigler, Abbey (NIH/NIGMS) [C Let me know if this is good or if STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1030https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{669EF01C-7579-40A0-B4AD-BB86AF96AA93}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
37323728The image visualizes a part of the yeast molecular interaction network. The lines in the network represent connections among genes (shown as little dots) and different-colored networks indicate subnetworks, for instance, those in specific locations or pathways in the cell. Researchers use gene or protein expression data to build these networks; the network shown here was visualized with a program called <a href="http://cytoscape.org/">Cytoscape</a>. By following changes in the architectures of these networks in response to altered environmental conditions, scientists can home in on those genes that become central "hubs" (highly connected genes), for example, when a cell encounters stress. They can then further investigate the precise role of these genes to uncover how a cell's molecular machinery deals with stress or other factors. Related to images <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3730">3730</a> and <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3733">3733</a>.12/17/2020 4:33:33 PM12/17/2020 4:33:33 PMType    Name    Media Type    File Size    Modified community17_L    Low 531 KB 6/3/2016 3:40 PM aamishral2 (NIH/NIGMS) [C They can then further investigate the STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx830https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{DF3B0E87-FCA0-4C7C-B290-A3CE0AF27370}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
27373327Molecular biologists are increasingly relying on bioinformatics software to visualize molecular interaction networks and to integrate these networks with data such as gene expression profiles. Related to <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2749">image 2749</a>.6/2/2022 6:16:40 PM6/2/2022 6:16:40 PMType    Name    Media Type    File Size    Modified Cytoscape_S    Low 173 KB 7/28/2016 4:05 PM Varkala, Venkat (NIH/NIGMS) [C Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx1770https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{67F7DB45-9727-4B4F-AB86-6631CB63E31E}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
23313147Like a world of its own, this sphere represents all the known chemical reactions in the <i>E. coli</i> bacterium. The colorful circles on the surface symbolize sets of densely interconnected reactions. The lines between the circles show additional connecting reactions. The shapes inside the circles are landmark molecules, like capital cities on a map, that either act as hubs for many groups of reactions, are highly conserved among species, or both. Molecules that connect far-flung reactions on the sphere are much more conserved during evolution than molecules that connect reactions within a single circle. This statistical cartography could reveal insights about other complex systems, such as protein interactions and gene regulation networks. Featured in the August 16, 2005, issue of <a href=http://publications.nigms.nih.gov/biobeat/05-08-16/#1 target="_blank"><em>Biomedical Beat</em></a>.10/29/2020 2:23:35 PM10/29/2020 2:23:35 PMType    Name    Media Type    File Size    Modified 2331_StatisticalCartography_S    Low 102 KB 3/29/2019 1:48 PM Constantinides, Stephen Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx830https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{54CCEE17-F454-495A-99DC-14F7511A6817}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131