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In 2006, scientists developed an optical microscopy technique enabling them to clearly see individual molecules within cells. In 2007, they took the technique, abbreviated STORM, a step further. They identified multicolored probes that let them peer into cells and clearly see multiple cellular components at the same time, such as these microtubules (green) and small hollows called clathrin-coated pits (red). Unlike conventional methods, the multicolor STORM technique produces a crisp and high resolution picture. A sharper view of how cellular components interact will likely help scientists answer some longstanding questions about cell biology. Featured in the October 17, 2007, issue of <a href=http://publications.nigms.nih.gov/biobeat/07-10-17/#1 target="_blank"><em>Biomedical Beat</em></a>.
10/29/2020 2:02:16 PM
10/29/2020 2:02:16 PM
In 2006, scientists developed an optical microscopy
technique
enabling them to clearly see individual molecules within
Tools and
Techniques
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A mouse's fat cells (red) are shown surrounded by a network of blood vessels (green). Fat cells store and release energy, protect organs and nerve tissues, insulate us from the cold and help us absorb important vitamins. This image is part of the Life: Magnified collection, which was displayed in the Gateway Gallery at Washington Dulles International Airport June 3, 2014, to January 21, 2015. To see all 46 images in this exhibit, go to https://www.nigms.nih.gov/education/life-magnified/Pages/default.aspx.
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Two cells over a 2-hour period. The one on the bottom left goes through programmed cell death, also known as apoptosis. The one on the top right goes through cell division, also called mitosis. This video was captured using a confocal microscope.
12/27/2021 4:57:37 PM
12/27/2021 4:57:37 PM
Type Name Media Type File Size Modified
Technique
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The two large, central, round shapes are ovaries from a typical fruit fly (<em>Drosophila melanogaster</em>). The small butterfly-like structures surrounding them are fruit fly ovaries where researchers suppressed the expression of a gene that controls microtubule polymerization and is necessary for normal development. This image was captured using a confocal laser scanning microscope. <Br><Br> Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6807">6807</a>.
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A combo of protein structures determined experimentally and computationally shows us the complete metabolic network of a heat-loving bacterium.
8/6/2020 4:36:05 PM
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This image is a computer-generated model of the approximately 4.2 million atoms of the HIV capsid, the shell that contains the virus' genetic material. Scientists determined the exact structure of the capsid and the proteins that it's made of using a variety of imaging techniques and analyses. They then entered these data into a supercomputer that produced the atomic-level image of the capsid. This structural information could be used for developing drugs that target the capsid, possibly leading to more effective therapies
11/14/2023 1:23:33 PM
11/14/2023 1:23:33 PM
Type Name Media Type File Size Modified
and the proteins that it's made of using a variety of imaging
techniques
and analyses
They then entered these data into a
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Two mouse fibroblasts, one of the most common types of cells in mammalian connective tissue. They play a key role in wound healing and tissue repair. This image was captured using structured illumination microscopy.
12/27/2021 4:20:11 PM
12/27/2021 4:20:11 PM
Type Name Media Type File Size Modified
Technique
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What looks like the gossamer wings of a butterfly is actually the retina of a mouse, delicately snipped to lay flat and sparkling with fluorescent molecules. The image is from a research project investigating the promise of gene therapy for glaucoma. It was created at an NIGMS-funded advanced microscopy facility that develops technology for imaging across many scales, from whole organisms to cells to individual molecules. <BR><BR> The ability to obtain high-resolution imaging of tissue as large as whole mouse retinas was made possible by a technique called large-scale mosaic confocal microscopy, which was pioneered by the NIGMS-funded National Center for Microscopy and Imaging Research. The technique is similar to Google Earth in that it computationally stitches together many small, high-resolution images. <BR><BR> More details: <BR><BR> Glaucoma is a progressive eye disease and the leading cause of irreversible blindness. It is characterized by the death of neurons in the retina called retinal ganglion cells. A number of studies over the past decade suggest that targeting these cells with gene therapy designed to prevent their death might slow the progression of glaucoma. <BR><BR> This study is investigating whether a non-disease-causing virus (adeno-associated virus serotype 2) can effectively deliver genes to retinal ganglion cells. The researchers introduced into the virus a gene for green fluorescent protein (GFP) so they could visualize how well the virus transduced the cells. <BR><BR> Two months after viral delivery of the fluorescent vector to the eyes of 7-month-old mice, the researchers examined the entire retinas of the subjects under a microscope. The ability to obtain high-resolution imaging of tissue as large as whole mouse retinas was made possible by a technique called large-scale mosaic confocal microscopy, which was pioneered by the NIGMS-funded National Center for Microscopy and Imaging Research. The technique is similar to Google Earth in that it computationally stitches together many small, high-resolution images. <BR><BR> The researchers observed GFP expression (yellow) in all parts of the retinal ganglion cells (blue), including the soma, axons and dendritic tree. These results suggest that a viral delivery system could deliver therapeutic genes to retinal ganglion cells for treating glaucoma and related diseases. <BR><BR> EQUIPMENT: Olympus FluoView™ FV1000 Confocal Microscope. Fluorophores: green fluorescent protein and Alexa Fluor 568. Non-glaucomatous DBA/2J-Gpnmb+ mice. <BR><BR> Reflecting on the work, the lead researcher [Keunyoung (“Christine”) Kim] says: “It is amazing to see intricate and artistically organized microscopic structures. … I encountered an entirely new world invisible to the naked eye—a galaxy of infinite secrets and endless potential for discovery.”
7/19/2023 8:25:17 PM
7/19/2023 8:25:17 PM
by a
technique
called large-scale mosaic confocal microscopy, which was pioneered by the
The
technique
is similar to Google Earth in that it computationally stitches together many
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How far and fast an infectious disease spreads across a community depends on many factors, including transportation. These U.S. maps, developed as part of an international study to simulate and analyze disease spread, chart daily commuting patterns. They show where commuters live (top) and where they travel for work (bottom). Green represents the fewest number of people whereas orange, brown, and white depict the most. Such information enables researchers and policymakers to visualize how an outbreak in one area can spread quickly across a geographic region. Featured in the August 15, 2007, issue of <a href=http://publications.nigms.nih.gov/biobeat/07-08-15/#1 target="_blank"><em>Biomedical Beat</em></a>.
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2320_mappingdisease1_S Low 134 KB 3/29/2019 1:49 PM Constantinides, Stephen (NIH
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This is a super-resolution LM image taken by Hiro Hakozaki and Masa Hoshijima of NCMIR. The image contains highlighted calcium channels in cardiac muscle using a technique called dSTORM. The microscope used in the NCMIR lab was built by Hiro Hakozaki.
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Type Name Media Type File Size Modified
dSTORM_Cardiac1_L Low 131 KB 6/3/2016 3:27 PM aamishral2 (NIH/NIGMS) [C
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An axolotl—a type of salamander—that has been genetically modified so that its developing nervous system glows purple and its Schwann cell nuclei appear light blue. Schwann cells insulate and provide nutrients to peripheral nerve cells. Researchers often study axolotls for their extensive regenerative abilities. They can regrow tails, limbs, spinal cords, brains, and more. The researcher who took this image focuses on the role of the peripheral nervous system during limb regeneration. <Br><Br> This image was captured using a stereo microscope. <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6927">6927</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6928">6928</a>.
3/28/2023 7:22:11 PM
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As this cell was undergoing cell division, it was imaged with two microscopy techniques: differential interference contrast (DIC) and confocal. The DIC view appears in blue and shows the entire cell. The confocal view appears in pink and shows the chromosomes.
1/27/2023 9:51:37 PM
1/27/2023 9:51:37 PM
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An oblong blue shape with a
with two different microscopy
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Two fruit fly (<em>Drosophila melanogaster</em>) larvae brains with neurons expressing fluorescently tagged tubulin protein. Tubulin makes up strong, hollow fibers called microtubules that play important roles in neuron growth and migration during brain development. This image was captured using confocal microscopy, and the color indicates the position of the neurons within the brain.
1/20/2022 7:49:11 PM
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Drosophila 3rd instar larval brain expressing neuronal tubulin-Wen Lu and Vladimir I. Gelfand_M Medium 175 KB
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Various views of a mouse brain that was genetically modified so that subpopulations of its neurons glow. Researchers often study mice because they share many genes with people and can shed light on biological processes, development, and diseases in humans. <Br><Br> This video was captured using a light sheet microscope. <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6929">6929</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6930">6930</a>.
3/28/2023 7:25:52 PM
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Various views of a zebrafish head with blood vessels shown in purple. Researchers often study zebrafish because they share many genes with humans, grow and reproduce quickly, and have see-through eggs and embryos, which make it easy to study early stages of development. <Br><Br> This video was captured using a light sheet microscope. <Br><Br> Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6934">6934</a>.
3/28/2023 7:28:33 PM
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Axolotls—a type of salamander—that have been genetically modified so that various parts of their nervous systems glow purple and green. Researchers often study axolotls for their extensive regenerative abilities. They can regrow tails, limbs, spinal cords, brains, and more. The researcher who took this image focuses on the role of the peripheral nervous system during limb regeneration. <Br><Br> This image was captured using a stereo microscope. <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6927">6927</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6932">6932</a>.
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The white circle in this image is a Petri dish, named for its inventor, Julius Richard Petri. These dishes are one of the most common pieces of equipment in biology labs, where researchers use them to grow cells.
3/24/2021 4:29:32 PM
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Luciferase-based imaging enables visualization and quantification of internal organs and transplanted cells in live adult zebrafish. In this image, a cardiac muscle-restricted promoter drives firefly luciferase expression. Lateral (Top) and overhead views (Bottom) are shown.
10/5/2020 5:20:22 AM
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Microtubules in African green monkey cells. Microtubules are strong, hollow fibers that provide cells with structural support. Here, the microtubules have been color-coded based on their distance from the microscope lens: purple is closest to the lens, and yellow is farthest away. This image was captured using Stochastic Optical Reconstruction Microscopy (STORM). <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6889">6889</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6890">6890</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6892">6892</a>.
4/4/2022 4:10:02 PM
4/4/2022 4:10:02 PM
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Lysosomes (yellow) and detyrosinated microtubules (light blue). Lysosomes are bubblelike organelles that take in molecules and use enzymes to break them down. Microtubules are strong, hollow fibers that provide structural support to cells. The researchers who took this image found that in epithelial cells, detyrosinated microtubules are a small subset of fibers, and they concentrate lysosomes around themselves. This image was captured using Stochastic Optical Reconstruction Microscopy (STORM). <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6890">6890</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6891">6891</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6892">6892</a>.
4/4/2023 8:32:04 PM
4/4/2023 8:32:04 PM
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A mouse brain that was genetically modified so that subpopulations of its neurons glow. Researchers often study mice because they share many genes with people and can shed light on biological processes, development, and diseases in humans. <Br><Br> This image was captured using a light sheet microscope. <Br><Br> Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6929">6929</a> and video <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6931">6931</a>.
3/28/2023 7:24:56 PM
3/28/2023 7:24:56 PM
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A zebrafish head with blood vessels shown in purple. Researchers often study zebrafish because they share many genes with humans, grow and reproduce quickly, and have see-through eggs and embryos, which make it easy to study early stages of development. <Br><Br> This image was captured using a light sheet microscope. <Br><Br> Related to video <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6933">6933</a>.
3/28/2023 7:29:10 PM
3/28/2023 7:29:10 PM
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This simulation of myosin V binding to actin was created using the software tool Protein Mechanica. With Protein Mechanica, researchers can construct models using information from a variety of sources: crystallography, cryo-EM, secondary structure descriptions, as well as user-defined solid shapes, such as spheres and cylinders. The goal is to enable experimentalists to quickly and easily simulate how different parts of a molecule interact.
8/21/2020 6:10:42 PM
8/21/2020 6:10:42 PM
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A macrophage—a type of immune cell that engulfs invaders—“eats” and is activated by a “two-faced” Janus particle. The particle is called “two-faced” because each of its two hemispheres is coated with a different type of molecule, shown here in red and cyan. During macrophage activation, a transcription factor tagged with a green fluorescence protein (NF-κB) gradually moves from the cell’s cytoplasm into its nucleus and causes DNA transcription. The distribution of molecules on “two-faced” Janus particles can be altered to control the activation of immune cells. Details on this “geometric manipulation” strategy can be found in the <em> Proceedings of the National Academy of Sciences</em> paper <a href="https://www.pnas.org/content/116/50/25106.long">"Geometrical reorganization of Dectin-1 and TLR2 on single phagosomes alters their synergistic immune signaling" </a> by Li et al. and the <em> Scientific Reports</em> paper<a href="https://www.nature.com/articles/s41598-021-92910-9"> "Spatial organization of FcγR and TLR2/1 on phagosome membranes differentially regulates their synergistic and inhibitory receptor crosstalk"</a> by Li et al. This video was captured using epi-fluorescence microscopy. <Br><Br>Related to video <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6800">6800</a>.
8/18/2023 12:40:34 PM
8/18/2023 12:40:34 PM
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A <em>Trigonium</em> diatom imaged by a quantitative orientation-independent differential interference contrast (OI-DIC) microscope. Diatoms are single-celled photosynthetic algae with mineralized cell walls that contain silica and provide protection and support. These organisms form an important part of the plankton at the base of the marine and freshwater food chains. The width of this image is 90 μm. <Br><Br> More information about the microscopy that produced this image can be found in the <em>Journal of Microscopy</em> paper <a href="https://onlinelibrary.wiley.com/doi/10.1111/jmi.12682/">“An Orientation-Independent DIC Microscope Allows High Resolution Imaging of Epithelial Cell Migration and Wound Healing in a Cnidarian Model”</a> by Malamy and Shribak.
1/27/2023 9:46:30 PM
1/27/2023 9:46:30 PM
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These microscopic roundworms, called <i>Caenorhabditis elegans</i>, lack eyes and the opsin proteins used by visual systems to detect colors. However, researchers found that the worms can still sense the color of light in a way that enables them to avoid pigmented toxins made by bacteria. This image was captured using a stereo microscope.
3/24/2021 5:44:57 PM
3/24/2021 5:44:57 PM
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This Petri dish contains microscopic roundworms called <i>Caenorhabditis elegans</i>. Researchers used these particular worms to study how <i>C. elegans</i> senses the color of light in its environment.
3/24/2021 5:46:13 PM
3/24/2021 5:46:13 PM
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Microtubules (magenta) and tau protein (light blue) in a cell model of tauopathy. Researchers believe that tauopathy—the aggregation of tau protein—plays a role in Alzheimer’s disease and other neurodegenerative diseases. This image was captured using Stochastic Optical Reconstruction Microscopy (STORM). <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6889">6889</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6890">6890</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6891">6891</a>.
4/4/2023 8:31:39 PM
4/4/2023 8:31:39 PM
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The nucleus of a human fibroblast cell with chromatin—a substance made up of DNA and proteins—shown in various colors. Fibroblasts are one of the most common types of cells in mammalian connective tissue, and they play a key role in wound healing and tissue repair. This image was captured using Stochastic Optical Reconstruction Microscopy (STORM). <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6888">6888</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6893">6893</a>.
4/4/2022 3:59:29 PM
4/4/2022 3:59:29 PM
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These colorful, computer-generated ribbons show the backbone of a molecule that glows a fluorescent red. The molecule, called mStrawberry, was created by chemists based on a protein found in the ruddy lips of a coral. Scientists use the synthetic molecule and other "fruity" ones like it as a dye to mark and study cell structures. Featured in the April 18, 2007, issue of <a href=http://publications.nigms.nih.gov/biobeat/07-04-18/#1 target="_blank"><em>Biomedical Beat</em></a>.
10/29/2020 1:18:41 PM
10/29/2020 1:18:41 PM
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The nucleus of a degenerating human tendon cell, also known as a tenocyte. It has been color-coded based on the density of chromatin—a substance made up of DNA and proteins. Areas of low chromatin density are shown in blue, and areas of high chromatin density are shown in red. This image was captured using Stochastic Optical Reconstruction Microscopy (STORM). <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6887">6887</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6888">6888</a>.
4/4/2023 8:31:20 PM
4/4/2023 8:31:20 PM
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Neutrophil-like cells (blue) in a microfluidic chip preferentially migrating toward LTB4 over fMLP. A neutrophil is a type of white blood cell that is part of the immune system and helps the body fight infection. Both LTB4 and fMLP are molecules involved in immune response. Microfluidic chips are small devices containing microscopic channels, and they are used in a range of applications, from basic research on cells to pathogen detection. The scale bar in this video is 500μm.
4/1/2022 8:13:40 PM
4/1/2022 8:13:40 PM
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This slide shows the technologies that the Joint Center for Structural Genomics developed for going from gene to structure and how the technologies have been integrated into a high-throughput pipeline, including all of the steps from target selection, parallel expression, protein purification, automated crystallization trials, automated crystal screening, structure determination, validation, and publication.
10/29/2020 4:14:36 PM
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This image results from a research project to visualize which regions of the adult fruit fly (Drosophila) brain derive from each neural stem cell. First, researchers collected several thousand fruit fly larvae and fluorescently stained a random stem cell in the brain of each. The idea was to create a population of larvae in which each of the 100 or so neural stem cells was labeled at least once. When the larvae grew to adults, the researchers examined the flies’ brains using confocal microscopy. </br>With this technique, the part of a fly’s brain that derived from a single, labeled stem cell “lights up.” The scientists photographed each brain and digitally colorized its lit-up area. By combining thousands of such photos, they created a 3-dimensional, color-coded map that shows which part of the Drosophila brain comes from each of its ~100 neural stem cells. In other words, each colored region shows which neurons are the progeny or “clones” of a single stem cell. This work established a hierarchical structure as well as nomenclature for the neurons in the Drosophila brain. Further research will relate functions to structures of the brain. Related to image <a href="/Pages/DetailPage.aspx?imageID2=5838">5838</a> and video<a href="/Pages/DetailPage.aspx?imageID2=5843"> 5843</a>.
5/13/2022 12:37:47 PM
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This image results from a research project to visualize which regions of the adult fruit fly (Drosophila) brain derive from each neural stem cell. First, researchers collected several thousand fruit fly larvae and fluorescently stained a random stem cell in the brain of each. The idea was to create a population of larvae in which each of the 100 or so neural stem cells was labeled at least once. When the larvae grew to adults, the researchers examined the flies’ brains using confocal microscopy. With this technique, the part of a fly’s brain that derived from a single, labeled stem cell “lights up.” The scientists photographed each brain and digitally colorized its lit-up area. By combining thousands of such photos, they created a 3-dimensional, color-coded map that shows which part of the Drosophila brain comes from each of its ~100 neural stem cells. In other words, each colored region shows which neurons are the progeny or “clones” of a single stem cell. This work established a hierarchical structure as well as nomenclature for the neurons in the Drosophila brain. Further research will relate functions to structures of the brain. Related to image <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=3808">5868</a> and video<a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=3749"> 5843</a>
5/13/2022 12:38:45 PM
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An <em> Arachnoidiscus</em> diatom with a diameter of 190µm. Diatoms are microscopic algae that have cell walls made of silica, which is the strongest known biological material relative to its density. In <em> Arachnoidiscus</em>, the cell wall is a radially symmetric pillbox-like shell composed of overlapping halves that contain intricate and delicate patterns. Sometimes, <em> Arachnoidiscus</em> is called “a wheel of glass.” <Br><Br> This image was taken with the orientation-independent differential interference contrast microscope.
7/13/2022 8:00:33 PM
7/13/2022 8:00:33 PM
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A fruit fly (<em>Drosophila melanogaster</em>) egg chamber with microtubules shown in green and actin filaments shown in red. Egg chambers are multicellular structures in fruit flies ovaries that each give rise to a single egg. Microtubules and actin filaments give the chambers structure and shape. This image was captured using a confocal microscope. <Br><Br> More information on the research that produced this image can be found in the <em> Current Biology</em> paper <a href="https://www.cell.com/current-biology/fulltext/S0960-9822(21)00669-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0960982221006692%3Fshowall%3Dtrue">"Gatekeeper function for Short stop at the ring canals of the <em>Drosophila</em> ovary"</a> by Lu et al.
2/18/2022 6:32:46 PM
2/18/2022 6:32:46 PM
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Br><Br> More information on the research that produced this image can be found in the <em> Current Biology
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The illustration shows the capsid of human immunodeficiency virus (HIV) whose molecular features were resolved with cryo-electron microscopy (cryo-EM). On the left, the HIV capsid is "naked," a state in which it would be easily detected by and removed from cells. However, as shown on the right, when the viral capsid binds to and is covered with a host protein, called cyclophilin A (shown in red), it evades detection and enters and invades the human cell to use it to establish an infection. To learn more about how cyclophilin A helps HIV infect cells and how scientists used cryo-EM to find out the mechanism by which the HIV capsid attaches to cyclophilin A, <a href="https://news.illinois.edu/blog/view/6367/335013">see this news release by the University of Illinois</a>. A study reporting these findings was published in the journal <a href="http://www.nature.com/ncomms/2016/160304/ncomms10714/full/ncomms10714.html"><i>Nature Communications</i></a>.
12/17/2020 6:19:59 PM
12/17/2020 6:19:59 PM
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HIV capsid square crop Thumbnail 152 KB 10/13/2016 12:57 PM Machalek, Alisa (NIH/NIAMS) [E
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Multicellular yeast called snowflake yeast that researchers created through many generations of directed evolution from unicellular yeast. Stained cell membranes (green) and cell walls (red) reveal the connections between cells. Younger cells take up more cell membrane stain, while older cells take up more cell wall stain, leading to the color differences seen here. This image was captured using spinning disk confocal microscopy. <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6970">6970</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6971">6971</a>.
2/6/2023 2:03:47 PM
2/6/2023 2:03:47 PM
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Br><Br> I'm more than happy
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Multicellular yeast called snowflake yeast that researchers created through many generations of directed evolution from unicellular yeast. Cells are connected to one another by their cell walls, shown in blue. Stained cytoplasm (green) and membranes (magenta) show that the individual cells remain separate. This image was captured using spinning disk confocal microscopy. <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6969">6969</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6971">6971</a>.
11/15/2023 1:15:17 PM
11/15/2023 1:15:17 PM
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Br><Br> I'm more than happy
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This image shows a computer-generated, three-dimensional map of the rotavirus structure. This virus infects humans and other animals and causes severe diarrhea in infants and young children. By the age of five, almost every child in the world has been infected with this virus at least once. Scientists have found a vaccine against rotavirus, so in the United States there are very few fatalities, but in developing countries and in places where the vaccine is unavailable, this virus is responsible for more than 450,000 deaths each year.<Br><Br> The rotavirus comprises three layers: the outer, middle and inner layers. On infection, the outer layer is removed, leaving behind a "double-layered particle." Researchers have studied the structure of this double-layered particle with a transmission electron microscope. Many images of the virus at a magnification of ~50,000x were acquired, and computational analysis was used to combine the individual particle images into a three-dimensional reconstruction. <Br><Br>The image was rendered by Melody Campbell (PhD student at TSRI). Work that led to the 3D map was published in Campbell et al. Movies of ice-embedded particles enhance resolution in electron cryo-microscopy. Structure. 2012;20(11):1823-8. PMCID: PMC3510009. <Br><Br>This image was part of the Life: Magnified collection, which was displayed in the Gateway Gallery at Washington Dulles International Airport June 3, 2014, to January 21, 2015. To see all 46 images in this exhibit, go to https://www.nigms.nih.gov/education/life-magnified/Pages/default.aspx.
11/22/2022 8:55:40 PM
11/22/2022 8:55:40 PM
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Carragher_Rota_Virus_M Medium 1505 KB 7/27/2016 10:54 AM Varkala, Venkat (NIH/NIGMS) [C
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<em>Staphylococcus aureus</em> bacteria (blue) on the porous coating of a femoral hip stem used in hip replacement surgery. The relatively rough surface of an implant is a favorable environment for bacteria to attach and grow. This can lead to the development of biofilms, which can cause infections. The researchers who took this image are working to understand where biofilms are likely to develop. This knowledge could support the prevention and treatment of infections. A scanning electron microscope was used to capture this image. <Br><Br>More information on the research that produced this image can be found in the <em>Antibiotics</em> paper<a href="https://www.mdpi.com/2079-6382/10/8/889"> "Free-floating aggregate and single-cell-initiated biofilms of <em>Staphylococcus aureus</em>" </a>by Gupta et al. <Br><Br>Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6803">6803</a> and video <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6805">6805</a>.
10/18/2023 2:56:58 PM
10/18/2023 2:56:58 PM
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S. aureus in the porous coating of a femoral stem_M Medium 73 KB 1/20/2022 1:51 PM Crowley, Rachel (NIH
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Two fruit fly (<em>Drosophila melanogaster</em>) egg cells, one on each side of the central black line. The colorful swirls show the circular movement of cytoplasm—called ooplasmic streaming—that occurs in late egg cell development in wild-type (right) and mutant (left) oocytes. This image was captured using confocal microscopy. <Br><Br> More information on the research that produced this image can be found in the <em>Journal of Cell Biology</em> paper <a href="https://rupress.org/jcb/article/217/10/3497/120275/Ooplasmic-flow-cooperates-with-transport-and">“Ooplasmic flow cooperates with transport and anchorage in <em>Drosophila</em> oocyte posterior determination”</a> by Lu et al.
1/21/2022 3:52:59 PM
1/21/2022 3:52:59 PM
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Drosophila ooplasmic streaming_T Thumbnail 2 KB 2/11/2022 1:41 PM Crowley, Rachel (NIH/NIGMS) [E
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Fruit fly (<em>Drosophila melanogaster</em>) ovaries with DNA shown in magenta and actin filaments shown in light blue. This image was captured using a confocal laser scanning microscope. <Br><Br> Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6806">6806</a>.
1/21/2022 3:54:37 PM
1/21/2022 3:54:37 PM
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6807_M Medium 503 KB 2/11/2022 2:22 PM Crowley, Rachel (NIH/NIGMS) [E
The image was acquired on a Nikon
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A 20-µm thick section of mouse midbrain. The nerve cells are transparent and weren’t stained. Instead, the color is generated by interaction of white polarized light with the molecules in the cells and indicates their orientation. <Br><Br>The image was obtained with a polychromatic polarizing microscope that shows the polychromatic birefringent image with hue corresponding to the slow axis orientation. More information about the microscopy that produced this image can be found in the <em>Scientific Reports</em> paper <a href="https://www.nature.com/articles/srep17340/">“Polychromatic Polarization Microscope: Bringing Colors to a Colorless World”</a> by Shribak.
6/30/2022 12:16:01 PM
6/30/2022 12:16:01 PM
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Brain Slice_S Low 10 KB 7/13/2022 4:07 PM Bigler, Abbey (NIH/NIGMS) [C
More information about the microscopy that produced this image can be found in
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Confocal image showing high levels of the protein vimentin (white) at the edge zone of a quail embryo. Cell nuclei are labeled green. More specifically, this high-magnification (60X) image shows vimentin immunofluorescence in the edge zone (top of image) and inner zone (bottom of image) of a Stage 4 quail blastoderm. Vimentin expression (white) is shown merged with Sytox nuclear labeling (green) at the edge of the blastoderm. A thick vimentin filament runs circumferentially (parallel to the direction of the edge) that appears to delineate the transition between the edge zone and interior zone. Also shown are dense vimentin clusters or foci, which typically appear to be closely associated with edge cell nuclei. This image appeared in a <a href=http://gtresearchnews.gatech.edu/quail-embryo/ target="_blank">March 2011 Georgia Tech news release</a>. An NIGMS grant to Professor Garcia was used to purchase the confocal microscope that collected this image. Related entries: 2808 and 2809.
12/22/2020 4:28:11 PM
12/22/2020 4:28:11 PM
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vimentin_hires High 403 KB 6/3/2016 3:18 PM aamishral2 (NIH/NIGMS) [C
Also shown are dense vimentin clusters or
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Microtubules (magenta) in neurons of the hippocampus, a part of the brain involved in learning and memory. Microtubules are strong, hollow fibers that provide structural support to cells. This image was captured using Stochastic Optical Reconstruction Microscopy (STORM). <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6889">6889</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6891">6891</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6892">6892</a>.
4/4/2023 8:30:37 PM
4/4/2023 8:30:37 PM
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Microtubules_S Low 27 KB 4/4/2022 10:57 AM Bigler, Abbey (NIH/NIGMS) [C
Let me know if this is good or if
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The image visualizes a part of the yeast molecular interaction network. The lines in the network represent connections among genes (shown as little dots) and different-colored networks indicate subnetworks, for instance, those in specific locations or pathways in the cell. Researchers use gene or protein expression data to build these networks; the network shown here was visualized with a program called <a href="http://cytoscape.org/">Cytoscape</a>. By following changes in the architectures of these networks in response to altered environmental conditions, scientists can home in on those genes that become central "hubs" (highly connected genes), for example, when a cell encounters stress. They can then further investigate the precise role of these genes to uncover how a cell's molecular machinery deals with stress or other factors. Related to images <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3730">3730</a> and <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3733">3733</a>.
12/17/2020 4:33:33 PM
12/17/2020 4:33:33 PM
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community17_L Low 531 KB 6/3/2016 3:40 PM aamishral2 (NIH/NIGMS) [C
They can then further investigate the
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Molecular biologists are increasingly relying on bioinformatics software to visualize molecular interaction networks and to integrate these networks with data such as gene expression profiles. Related to <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2749">image 2749</a>.
6/2/2022 6:16:40 PM
6/2/2022 6:16:40 PM
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Cytoscape_S Low 173 KB 7/28/2016 4:05 PM Varkala, Venkat (NIH/NIGMS) [C
Tools and
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Like a world of its own, this sphere represents all the known chemical reactions in the <i>E. coli</i> bacterium. The colorful circles on the surface symbolize sets of densely interconnected reactions. The lines between the circles show additional connecting reactions. The shapes inside the circles are landmark molecules, like capital cities on a map, that either act as hubs for many groups of reactions, are highly conserved among species, or both. Molecules that connect far-flung reactions on the sphere are much more conserved during evolution than molecules that connect reactions within a single circle. This statistical cartography could reveal insights about other complex systems, such as protein interactions and gene regulation networks. Featured in the August 16, 2005, issue of <a href=http://publications.nigms.nih.gov/biobeat/05-08-16/#1 target="_blank"><em>Biomedical Beat</em></a>.
10/29/2020 2:23:35 PM
10/29/2020 2:23:35 PM
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2331_StatisticalCartography_S Low 102 KB 3/29/2019 1:48 PM Constantinides, Stephen
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