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6806969The two large, central, round shapes are ovaries from a typical fruit fly (<em>Drosophila melanogaster</em>). The small butterfly-like structures surrounding them are fruit fly ovaries where researchers suppressed the expression of a gene that controls microtubule polymerization and is necessary for normal development. This image was captured using a confocal laser scanning microscope. <Br><Br> Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6807">6807</a>. 1/21/2022 3:55:03 PM1/21/2022 3:55:03 PMType    Name    Media Type    File Size    Modified Wild-type and mutant fruit fly ovaries_M    Medium 119 KB 2/11/2022 1:44 PM Dolan, Lauren (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx16440https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{1CE96574-AF64-43B2-8987-EDADC4899FE7}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
7010984An adult Hawaiian bobtail squid, <em>Euprymna scolopes</em>, (~4 cm) surrounded by newly hatched juveniles (~2 mm) in a bowl of seawater. <Br><Br>Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=7011">7011</a> and video <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=7012">7012</a>. 4/5/2024 7:52:37 PM4/5/2024 7:52:37 PMType    Name    Media Type    File Size    Modified This material is free of copyright restrictions The labs of Margaret J. McFall-Ngai, Carnegie Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx10230https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{F177861B-8657-49C6-9CBA-1788EB46014A}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2771430Under the microscope, an <i>E. coli</i> cell lights up like a fireball. Each bright dot marks a surface protein that tells the bacteria to move toward or away from nearby food and toxins. Using a new imaging technique, researchers can map the proteins one at a time and combine them into a single image. This lets them study patterns within and among protein clusters in bacterial cells, which don't have nuclei or organelles like plant and animal cells. Seeing how the proteins arrange themselves should help researchers better understand how cell signaling works. A movie containing this image was featured in the August 19, 2009, issue of <a href=http://publications.nigms.nih.gov/biobeat/09-08-19/index.html#1 target="_blank"><em>Biomedical Beat</em></a>.8/28/2020 5:59:20 PM8/28/2020 5:59:20 PMType    Name    Media Type    File Size    Modified Using a new imaging technique, researchers can map the proteins one at a time and combine STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15140https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{12F702C2-09EA-4026-A4FF-44FEB4FB31A5}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3600742A mouse's fat cells (red) are shown surrounded by a network of blood vessels (green). Fat cells store and release energy, protect organs and nerve tissues, insulate us from the cold and help us absorb important vitamins. This image is part of the Life: Magnified collection, which was displayed in the Gateway Gallery at Washington Dulles International Airport June 3, 2014, to January 21, 2015. To see all 46 images in this exhibit, go to https://www.nigms.nih.gov/education/life-magnified/Pages/default.aspx.11/22/2022 8:43:42 PM11/22/2022 8:43:42 PMType    Name    Media Type    File Size    Modified 7_right_Fat_cells_and_blood_vessel_34in_Malide_H    High 4848 KB 10/19/2020 3:10 AM Harris, Donald (NIH STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx14450https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{F5343960-E864-40C3-A794-C1F7F1C9CD4F}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
7016934The light organ (~0.5 mm across) of a juvenile Hawaiian bobtail squid, <em>Euprymna scolopes</em>, stained blue. The two pairs of ciliated appendages, or “arms,” on the sides of the organ move <em>Vibrio fischeri</em> bacterial cells closer to the two sets of three pores at the base of the arms that each lead to an interior crypt. This image was taken using a confocal fluorescence microscope. <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=7017">7017</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=7018">7018</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=7019">7019</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=7020">7020</a>. 4/12/2024 1:06:30 PM4/12/2024 1:06:30 PMType    Name    Media Type    File Size    Modified Pores on the surface of the Hawaiian bobtail squid light organ We, the creators/owners of these Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx121100https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{192BA578-DF3E-4CBD-A64B-8DDCA53264FB}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
67541006In many animals, the egg cell develops alongside sister cells. These sister cells are called nurse cells in the fruit fly (<em>Drosophila melanogaster</em>), and their job is to “nurse” an immature egg cell, or oocyte. Toward the end of oocyte development, the nurse cells transfer all their contents into the oocyte in a process called nurse cell dumping. This video captures this transfer, showing significant shape changes on the part of the nurse cells (blue), which are powered by wavelike activity of the protein myosin (red). Researchers created the video using a confocal laser scanning microscope. Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6753">6753</a>.7/20/2021 3:43:33 PM7/20/2021 3:43:33 PMType    Name    Media Type    File Size    Modified Fruit fly nurse cell video (1)    High 23777 KB 3/25/2021 4:51 PM Walter, Taylor (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13440https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{832C5196-E92F-48A5-B7CD-AF878621F7A3}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2767429A research mentor (Lori Eidson) and student (Nina Waldron, on the microscope) were 2009 members of the BRAIN (Behavioral Research Advancements In Neuroscience) program at Georgia State University in Atlanta. This program is an undergraduate summer research experience funded in part by NIGMS.8/28/2020 5:55:19 PM8/28/2020 5:55:19 PMType    Name    Media Type    File Size    Modified 2767_Research_mentor_and_S    Low 89 KB 3/29/2019 10:56 AM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15030https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{17C50E5A-1D3E-40D2-A327-B4B098B9FFBA}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3590800Developing spermatids (precursors of mature sperm cells) begin as small, round cells and mature into long-tailed, tadpole-shaped ones. In the sperm cell's head is the cell nucleus; in its tail is the power to outswim thousands of competitors to fertilize an egg. As seen in this microscopy image, fruit fly spermatids start out as bouquets of interconnected cells. A small lipid molecule called PIP2 helps spermatids tell their heads from their tails. Here, PIP2 (red) marks the nuclei and a cell skeleton-building protein called tubulin (green) marks the tails. When PIP2 levels are too low, some spermatids get mixed up and grow with their heads at the wrong end. Because sperm development is similar across species, studies in fruit flies could help researchers understand male infertility in humans.8/23/2023 2:01:13 PM8/23/2023 2:01:13 PMType    Name    Media Type    File Size    Modified Fabian_et_al-cover_pic_1-RGB2    Other 10234 KB 10/19/2020 1:52 AM Harris, Donald (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx14240https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{1E653F9B-A3DB-4BB0-AC1F-1A9089E37998}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
5772773Ovarioles in female insects are tubes in which egg cells (called oocytes) form at one end and complete their development as they reach the other end of the tube. This image, taken with a confocal microscope, shows ovarioles in a very popular lab animal, the fruit fly Drosophila. The basic structure of ovarioles supports very rapid egg production, with some insects (like termites) producing several thousand eggs per day. Each insect ovary typically contains 4–8 ovarioles, but this number varies widely depending on the insect species. <Br><Br>Scientists use insect ovarioles, for example, to study the basic processes that help various insects, including those that cause disease (like some mosquitos and biting flies), reproduce very quickly.12/18/2020 7:51:27 PM12/18/2020 7:51:27 PMType    Name    Media Type    File Size    Modified Kirilly04-ovaries_M    Medium 67 KB 8/4/2016 10:58 AM Varkala, Venkat (NIH/NIGMS) [C Please let me know if you have any STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx253120https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{2F3BB903-70BD-41BD-83EC-FFDE93D625AB}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6781869The green spots in this mouse brain are cells labeled with Calling Cards, a technology that records molecular events in brain cells as they mature. Understanding these processes during healthy development can guide further research into what goes wrong in cases of neuropsychiatric disorders. Also fluorescently labeled in this video are neurons (red) and nuclei (blue). Calling Cards and its application are described in the <em>Cell</em> paper “<a href=https://www.sciencedirect.com/science/article/pii/S009286742030814X>Self-Reporting Transposons Enable Simultaneous Readout of Gene Expression and Transcription Factor Binding in Single Cells</a>” by Moudgil et al.; and the <em>Proceedings of the National Academy of Sciences</em> paper “<a href=https://www.pnas.org/content/117/18/10003>A viral toolkit for recording transcription factor–DNA interactions in live mouse tissues</a>” by Cammack et al. This video was created for the <em>NIH Director’s Blog</em> post <a href=https://directorsblog.nih.gov/2021/08/24/the-amazing-brain-tracking-molecular-events-with-calling-cards-in-the-living-brain>The Amazing Brain: Tracking Molecular Events with Calling Cards</a>. <Br><Br> Related to image <a href=https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6780>6780</a>.7/17/2023 4:43:08 PM7/17/2023 4:43:08 PMType    Name    Media Type    File Size    Modified mouse-brain-2-720_mp4_hd    Other 21462 KB 9/10/2021 1:14 PM Dolan, Lauren (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx12960https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{159782BB-22BC-4404-AACB-1A0649C7AB3B}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
7015933<em>Vibrio fischeri</em> cells (~ 2 mm), labeled with green fluorescent protein (GFP), passing through a very narrow bottleneck in the tissues (red) of the Hawaiian bobtail squid, <em>Euprymna scolopes</em>, on the way to the crypts where the symbiont population resides. This image was taken using a confocal fluorescence microscope.4/12/2024 1:02:20 PM4/12/2024 1:02:20 PMType    Name    Media Type    File Size    Modified Margaret J. McFall-Ngai (Carnegie Institution/Caltech) and Edward G. Ruby (Caltech) All these images and videos were produced Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx11180https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{27E944E2-31D0-4B0F-8F97-384D26C2FFB7}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6790872Two cells over a 2-hour period. The one on the bottom left goes through programmed cell death, also known as apoptosis. The one on the top right goes through cell division, also called mitosis. This video was captured using a confocal microscope. 12/27/2021 4:57:37 PM12/27/2021 4:57:37 PMType    Name    Media Type    File Size    Modified Technique: Structured Illumination Microscopy (SIM) Video: DNA during cell death and Technique: Confocal STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15730https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{CC8B5303-F2D9-4014-B9B9-68597C41C367}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3740694Nodes of Ranvier are short gaps in the myelin sheath surrounding myelinated nerve cells (axons). Myelin insulates axons, and the node of Ranvier is where the axon is exposed to the extracellular environment, allowing for the transmission of action potentials at these nodes via ion flows between the inside and outside of the axon. The image shows a cross-section through the node, with the surrounding ECM encasing and supporting the axon shown in cyan.12/17/2020 4:42:11 PM12/17/2020 4:42:11 PMType    Name    Media Type    File Size    Modified Node_of_Ranvier2    High 929 KB 6/3/2016 3:40 PM aamishral2 (NIH/NIGMS) [C Nodes of Ranvier are short gaps in STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx180150https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{8F452BFD-D560-46A0-B945-E3470BDBDD41}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2702488A combo of protein structures determined experimentally and computationally shows us the complete metabolic network of a heat-loving bacterium.8/6/2020 4:36:05 PM8/6/2020 4:36:05 PMType    Name    Media Type    File Size    Modified 2702_Thermotoga_maritima_and_its_metabolic_network_T    Thumbnail 97 KB 3/29/2019 11:00 AM Constantinides STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15130https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{8BCB0A5C-8081-41B2-AEC1-62DCCD78EE99}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3339387This is a super-resolution LM image taken by Hiro Hakozaki and Masa Hoshijima of NCMIR. The image contains highlighted calcium channels in cardiac muscle using a technique called dSTORM. The microscope used in the NCMIR lab was built by Hiro Hakozaki.12/23/2020 5:37:10 PM12/23/2020 5:37:10 PMType    Name    Media Type    File Size    Modified dSTORM_Cardiac1_L    Low 131 KB 6/3/2016 3:27 PM aamishral2 (NIH/NIGMS) [C Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15970https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{0E46207E-187E-4107-BAE4-5B30FD3E8DE2}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6899883High-resolution time lapse of epithelial (skin) cell migration and wound healing. It shows an image taken every 13 seconds over the course of almost 14 minutes. The images were captured with quantitative orientation-independent differential interference contrast (DIC) microscope (left) and a conventional DIC microscope (right). <Br><Br>More information about the research that produced this video can be found in the <em>Journal of Microscopy</em> paper <a href="https://onlinelibrary.wiley.com/doi/10.1111/jmi.12682/">“An Orientation-Independent DIC Microscope Allows High Resolution Imaging of Epithelial Cell Migration and Wound Healing in a Cnidarian Model”</a> by Malamy and Shribak. 6/30/2022 4:45:48 PM6/30/2022 4:45:48 PMType    Name    Media Type    File Size    Modified circularlamellipodia    High 17708 KB 6/30/2022 3:03 PM Crowley, Rachel (NIH/NIGMS) [E STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx12360https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{497BC427-08F6-402E-B25B-3FF48F096460}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6601904This animation shows atoms of the HIV capsid, the shell that encloses the virus's genetic material. Scientists determined the exact structure of the capsid using a variety of imaging techniques and analyses. They then entered this data into a supercomputer to produce this image. Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=3477">3477</a>. 11/14/2023 1:23:27 PM11/14/2023 1:23:27 PMType    Name    Media Type    File Size    Modified Atomic-Level Structure of the HIV Capsid    High 20229 KB 12/10/2020 5:41 PM Walter, Taylor (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15290https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{2C77B30F-B214-4301-B475-E0433A651C12}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3477729This image is a computer-generated model of the approximately 4.2 million atoms of the HIV capsid, the shell that contains the virus' genetic material. Scientists determined the exact structure of the capsid and the proteins that it's made of using a variety of imaging techniques and analyses. They then entered these data into a supercomputer that produced the atomic-level image of the capsid. This structural information could be used for developing drugs that target the capsid, possibly leading to more effective therapies11/14/2023 1:23:33 PM11/14/2023 1:23:33 PMType    Name    Media Type    File Size    Modified and the proteins that it's made of using a variety of imaging techniques and analyses They then entered these data into a STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15430https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{4475C347-ACA7-4D71-B1A5-B70167940ACF}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
7012986Each morning, the nocturnal Hawaiian bobtail squid, <em>Euprymna scolopes</em>, hides from predators by digging into the sand. At dusk, it leaves the sand again to hunt. <Br><Br>Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=7010">7010</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=7011">7011</a>. 4/5/2024 7:56:21 PM4/5/2024 7:56:21 PMType    Name    Media Type    File Size    Modified Adult squid burying    High 848 KB 4/17/2024 10:22 AM aamershaha (NIH/NIGMS) [C Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx11330https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{BAD9BAA2-8A5F-49B8-93C1-DE40B7A7F6C2}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3730758The image visualizes a part of the yeast molecular interaction network. The lines in the network represent connections among genes (shown as little dots) and different-colored networks indicate subnetworks, for instance, those in specific locations or pathways in the cell. Researchers use gene or protein expression data to build these networks; the network shown here was visualized with a program called <a href="http://cytoscape.org/">Cytoscape</a>. By following changes in the architectures of these networks in response to altered environmental conditions, scientists can home in on those genes that become central "hubs" (highly connected genes), for example, when a cell encounters stress. They can then further investigate the precise role of these genes to uncover how a cell's molecular machinery deals with stress or other factors. Related to images <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3732">3732</a> and <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3733">3733</a>.12/17/2020 4:31:12 PM12/17/2020 4:31:12 PMType    Name    Media Type    File Size    Modified structure-aware-layout_T    Thumbnail 22 KB 6/3/2016 3:40 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13350https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{B968CB61-8A47-4104-B475-7624CA1C1DE0}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3556670Luciferase-based imaging enables visualization and quantification of internal organs and transplanted cells in live adult zebrafish. In this image, a cardiac muscle-restricted promoter drives firefly luciferase expression. Lateral (Top) and overhead views (Bottom) are shown.10/5/2020 5:20:22 AM10/5/2020 5:20:22 AMType    Name    Media Type    File Size    Modified Poss-zebrafish-01    High 416 KB 6/3/2016 3:31 PM aamishral2 (NIH/NIGMS) [C br>For imagery of the overhead STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx16580https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{3D1F01B8-728A-4F3D-B381-CF2B50DEAA2C}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3729757In this video, Rice University scientists used molecular modeling with a mathematical algorithm called AWSEM (for associative memory, water-mediated, structure and energy model) and structural data to analyze how a transcription factor called nuclear factor kappa B (NFkB) is removed from DNA to stop gene activation. AWSEM uses the interacting energies of their components to predict how proteins fold. At the start, the NFkB dimer (green and yellow, in the center) grips DNA (red, to the left), which activates the transcription of genes. IkB (blue, to the right), an inhibitor protein, stops transcription when it binds to NFkB and forces the dimer to twist and release its hold on DNA. The yellow domain at the bottom of IkB is the PEST domain, which binds first to NFkB. For more details about this mechanism called molecular stripping, see <a href="http://news.rice.edu/2015/12/21/a-new-twist-in-genetic-switches-2/">here</a>.2/4/2020 5:39:29 PM2/4/2020 5:39:29 PMType    Name    Media Type    File Size    Modified 3729_FInal_Movie2_high_thumbnail    Thumbnail 65 KB 3/12/2019 12:28 PM Constantinides, Stephen (NIH/NIGMS STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx140120https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{BAEF5C9F-F2B6-47FE-8AEA-3F668FCABCC3}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3559673Luciferase-based imaging enables visualization and quantification of internal organs and transplanted cells in live adult zebrafish. This image shows how luciferase-based imaging could be used to visualize the heart for regeneration studies (left), or label all tissues for stem cell transplantation (right).10/5/2020 5:27:55 AM10/5/2020 5:27:55 AMType    Name    Media Type    File Size    Modified Poss-zebrafish-04_L    Low 35 KB 6/3/2016 3:31 PM aamishral2 (NIH/NIGMS) [C br>For imagery of both the STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx16770https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{7E206F11-67B8-4B43-BEA6-8DD760F163C4}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6891878Microtubules in African green monkey cells. Microtubules are strong, hollow fibers that provide cells with structural support. Here, the microtubules have been color-coded based on their distance from the microscope lens: purple is closest to the lens, and yellow is farthest away. This image was captured using Stochastic Optical Reconstruction Microscopy (STORM). <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6889">6889</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6890">6890</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6892">6892</a>. 4/4/2022 4:10:02 PM4/4/2022 4:10:02 PMType    Name    Media Type    File Size    Modified MicrotubulesinMonkeyCells_M    Medium 240 KB 4/4/2022 10:39 AM Bigler, Abbey (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx152100https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{1F39E3DF-F3C9-48A9-9597-492A967EA195}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2357248This ACAPELLA robot for capillary protein crystallization grows protein crystals, freezes them, and centers them without manual intervention. The close-up is a view of one of the dispensers used for dispensing proteins and reagents.10/29/2020 3:49:11 PM10/29/2020 3:49:11 PMType    Name    Media Type    File Size    Modified hi_ACAPELLA_L    Low 72 KB 6/3/2016 3:09 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13060https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{7331CD7F-A0B3-4872-BAD9-2422C41200EB}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
69311024Various views of a mouse brain that was genetically modified so that subpopulations of its neurons glow. Researchers often study mice because they share many genes with people and can shed light on biological processes, development, and diseases in humans. <Br><Br> This video was captured using a light sheet microscope. <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6929">6929</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6930">6930</a>. 3/28/2023 7:25:52 PM3/28/2023 7:25:52 PMType    Name    Media Type    File Size    Modified MouseBrainThumbnail    Thumbnail 251 KB 3/28/2023 1:42 PM Bigler, Abbey (NIH/NIGMS) [C Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15070https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{E8BA1CD7-FBAD-470A-8536-1897FD575924}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6933974Various views of a zebrafish head with blood vessels shown in purple. Researchers often study zebrafish because they share many genes with humans, grow and reproduce quickly, and have see-through eggs and embryos, which make it easy to study early stages of development. <Br><Br> This video was captured using a light sheet microscope. <Br><Br> Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6934">6934</a>. 3/28/2023 7:28:33 PM3/28/2023 7:28:33 PMType    Name    Media Type    File Size    Modified Zebrafish    High 79865 KB 3/28/2023 2:27 PM Bigler, Abbey (NIH/NIGMS) [C Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx17240https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{51C6DED5-0B9A-4BCB-BB8C-2DEF96D5D9F7}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
5793778What looks like the gossamer wings of a butterfly is actually the retina of a mouse, delicately snipped to lay flat and sparkling with fluorescent molecules. The image is from a research project investigating the promise of gene therapy for glaucoma. It was created at an NIGMS-funded advanced microscopy facility that develops technology for imaging across many scales, from whole organisms to cells to individual molecules. <BR><BR> The ability to obtain high-resolution imaging of tissue as large as whole mouse retinas was made possible by a technique called large-scale mosaic confocal microscopy, which was pioneered by the NIGMS-funded National Center for Microscopy and Imaging Research. The technique is similar to Google Earth in that it computationally stitches together many small, high-resolution images. <BR><BR> More details: <BR><BR> Glaucoma is a progressive eye disease and the leading cause of irreversible blindness. It is characterized by the death of neurons in the retina called retinal ganglion cells. A number of studies over the past decade suggest that targeting these cells with gene therapy designed to prevent their death might slow the progression of glaucoma. <BR><BR> This study is investigating whether a non-disease-causing virus (adeno-associated virus serotype 2) can effectively deliver genes to retinal ganglion cells. The researchers introduced into the virus a gene for green fluorescent protein (GFP) so they could visualize how well the virus transduced the cells. <BR><BR> Two months after viral delivery of the fluorescent vector to the eyes of 7-month-old mice, the researchers examined the entire retinas of the subjects under a microscope. The ability to obtain high-resolution imaging of tissue as large as whole mouse retinas was made possible by a technique called large-scale mosaic confocal microscopy, which was pioneered by the NIGMS-funded National Center for Microscopy and Imaging Research. The technique is similar to Google Earth in that it computationally stitches together many small, high-resolution images. <BR><BR> The researchers observed GFP expression (yellow) in all parts of the retinal ganglion cells (blue), including the soma, axons and dendritic tree. These results suggest that a viral delivery system could deliver therapeutic genes to retinal ganglion cells for treating glaucoma and related diseases. <BR><BR> EQUIPMENT: Olympus FluoView™ FV1000 Confocal Microscope. Fluorophores: green fluorescent protein and Alexa Fluor 568. Non-glaucomatous DBA/2J-Gpnmb+ mice. <BR><BR> Reflecting on the work, the lead researcher [Keunyoung (“Christine”) Kim] says: “It is amazing to see intricate and artistically organized microscopic structures. … I encountered an entirely new world invisible to the naked eye—a galaxy of infinite secrets and endless potential for discovery.” 7/19/2023 8:25:17 PM7/19/2023 8:25:17 PMby a technique called large-scale mosaic confocal microscopy, which was pioneered by the The technique is similar to Google Earth in that it computationally stitches together many STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx16190https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{E2CC74AB-01A0-4BBC-964B-CF278FF727BA}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6568854These images illustrate a technique combining cryo-electron tomography and super-resolution fluorescence microscopy called correlative imaging by annotation with single molecules (CIASM). CIASM enables researchers to identify small structures and individual molecules in cells that they couldn’t using older techniques. 12/22/2020 3:22:47 PM12/22/2020 3:22:47 PMType    Name    Media Type    File Size    Modified Figure_2_72dpi    Thumbnail 63 KB 7/16/2020 3:27 PM Harris, Donald (NIH/NIGMS) [C Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13030https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{93F7C98F-C6A0-4FA2-A019-AA17C2A1B17F}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
7018936A light organ (~0.5 mm across) of a juvenile Hawaiian bobtail squid, <em>Euprymna scolopes</em>. Movement of cilia on the surface of the organ aggregates bacterial symbionts (green) into two areas above sets of pores that lead to interior crypts. This image was taken using a confocal fluorescence microscope. <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=7016">7016</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=7017">7017</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=7019">7019</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=7020">7020</a>. 4/12/2024 1:09:51 PM4/12/2024 1:09:51 PMType    Name    Media Type    File Size    Modified Bacterial cells aggregating above the light organ of the Hawaiian bobtail squid Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx11460https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{02C15366-5DC0-4B82-99C0-9A10251E5B12}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2754492This simulation of myosin V binding to actin was created using the software tool Protein Mechanica. With Protein Mechanica, researchers can construct models using information from a variety of sources: crystallography, cryo-EM, secondary structure descriptions, as well as user-defined solid shapes, such as spheres and cylinders. The goal is to enable experimentalists to quickly and easily simulate how different parts of a molecule interact.8/21/2020 6:10:42 PM8/21/2020 6:10:42 PMType    Name    Media Type    File Size    Modified mv_dimer_T    Thumbnail 4 KB 6/3/2016 3:17 PM aamishral2 (NIH/NIGMS) [C Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx12870https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{0B867130-6ACF-4FC5-A90B-30B55CA4182D}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
7011985An adult Hawaiian bobtail squid, <em>Euprymna scolopes</em>, swimming next to a submerged hand. <Br><Br>Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=7010">7010</a> and video <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=7012">7012</a>. 4/5/2024 7:54:49 PM4/5/2024 7:54:49 PMType    Name    Media Type    File Size    Modified Margaret J. McFall-Ngai (Carnegie Institution/Caltech) and Edward G. Ruby (Caltech) All these images and videos were Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx97100https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{E01C7353-B358-485A-8542-0B4ED6593201}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6789871Two mouse fibroblasts, one of the most common types of cells in mammalian connective tissue. They play a key role in wound healing and tissue repair. This image was captured using structured illumination microscopy. 12/27/2021 4:20:11 PM12/27/2021 4:20:11 PMType    Name    Media Type    File Size    Modified Technique: Structured Illumination Microscopy (SIM) Video: DNA during cell death and Technique: Confocal STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx16330https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{911FF0EB-C528-450C-93F7-22CEEFA45FCF}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6352720This image shows how the CRISPR surveillance complex is disabled by two copies of anti-CRISPR protein AcrF1 (red) and one AcrF2 (light green). These anti-CRISPRs block access to the CRISPR RNA (green tube) preventing the surveillance complex from scanning and targeting invading viral DNA for destruction. 12/21/2020 5:09:58 PM12/21/2020 5:09:58 PMType    Name    Media Type    File Size    Modified CRISPR 2 of 2 NRAMM    High 197 KB 11/29/2017 11:59 AM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13350https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{152D7892-75BF-4DA9-913D-B1FCC618DA85}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3414527X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Found in the journal, Nature, Chemical Biology 8, 366-374 (2012). Series of seven images. Related to <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3413">image 3413</a> , <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3415">image 3415</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3416">image 3416</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3417">image 3417</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3418">image 3418</a> and <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3419">image 3419</a>.12/23/2020 11:04:41 PM12/23/2020 11:04:41 PMType    Name    Media Type    File Size    Modified binding_site_of_Src_kinase_for_macrocycle_inhibitors    High 375 KB 6/3/2016 3:28 PM aamishral2 (NIH/NIGMS STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx12250https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{FC3B2E45-4B75-43F5-AB53-B66E4E536897}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
69031019Real-time movie of young squids. Squids are often used as research organisms due to having the largest nervous system of any invertebrate, complex behaviors like instantaneous camouflage, and other unique traits. <Br><Br>This video was taken with polychromatic polarization microscope, as described in the <em>Scientific Reports</em> paper <a href=" https://www.nature.com/articles/srep17340/">“Polychromatic Polarization Microscope: Bringing Colors to a Colorless World”</a> by Shribak. The color is generated by interaction of white polarized light with the squid’s transparent soft tissue. The tissue works as a living tunable spectral filter, and the transmission band depends on the molecular orientation. When the young squid is moving, the tissue orientation changes, and its color shifts accordingly. 1/5/2024 1:57:43 PM1/5/2024 1:57:43 PMType    Name    Media Type    File Size    Modified Tools and Techniques https://www.nature.com/articles/srep17340 --this reference is just to show the technique STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15460https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{ABADE292-B556-4A17-BD4E-BDDEC4893BEA}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6572858The 3D single-molecule super-resolution reconstruction of the entire nuclear lamina in a HeLa cell was acquired using the TILT3D platform. TILT3D combines a tilted light sheet with point-spread function (PSF) engineering to provide a flexible imaging platform for 3D single-molecule super-resolution imaging in mammalian cells. <br> See <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6573">6573</a> for 3 seperate views of this structure.<br>12/22/2020 3:20:41 PM12/22/2020 3:20:41 PMType    Name    Media Type    File Size    Modified NuclearLamina_300dpi_M    Medium 117 KB 7/16/2020 5:42 PM Harris, Donald (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx14160https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{D065B67F-284D-48AA-98C1-513E4A756EF1}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6932973An axolotl—a type of salamander—that has been genetically modified so that its developing nervous system glows purple and its Schwann cell nuclei appear light blue. Schwann cells insulate and provide nutrients to peripheral nerve cells. Researchers often study axolotls for their extensive regenerative abilities. They can regrow tails, limbs, spinal cords, brains, and more. The researcher who took this image focuses on the role of the peripheral nervous system during limb regeneration. <Br><Br> This image was captured using a stereo microscope. <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6927">6927</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6928">6928</a>. 3/28/2023 7:22:11 PM3/28/2023 7:22:11 PMType    Name    Media Type    File Size    Modified Purple Axolotl_M    Medium 92 KB 3/28/2023 2:13 PM Bigler, Abbey (NIH/NIGMS) [C Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15570https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{C3BEC74E-68A6-4729-9CC3-F59BF6253164}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
67981013Yeast cells with nuclear envelopes shown in magenta and tubulin shown in light blue. The nuclear envelope defines the borders of the nucleus, which houses DNA. Tubulin is a protein that makes up microtubules—strong, hollow fibers that provide structure to cells and help direct chromosomes during cell division. This image was captured using wide-field microscopy with deconvolution. <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6791">6791</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6792">6792</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6793">6793</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6794">6794</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6797">6797</a>, and videos <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6795">6795</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6796">6796</a>.7/17/2023 5:07:46 PM7/17/2023 5:07:46 PMType    Name    Media Type    File Size    Modified YeastCells8_M    Low 19 KB 1/28/2022 2:22 PM Dolan, Lauren (NIH/NIGMS) [C Permission email: Hi Abbey, My name STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx14750https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{3BE03231-0BFB-4A6D-93AC-9F52ADA3C1C4}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2332108This fingertip-shaped group of lights is a microscopic crystal called a quantum dot. About 10,000 times thinner than a sheet of paper, the dot radiates brilliant colors under ultraviolet light. Dots such as this one allow researchers to label and track individual molecules in living cells and may soon be used for speedy disease diagnosis, DNA testing, and screening for illegal drugs. Featured in the April 18, 2006, issue of <a href=http://publications.nigms.nih.gov/biobeat/06-04-18/ target="_blank"><em>Biomedical Beat</em></a>.10/29/2020 2:26:34 PM10/29/2020 2:26:34 PMType    Name    Media Type    File Size    Modified tiny_points_of_light_M    Medium 20 KB 6/3/2016 3:08 PM aamishral2 (NIH/NIGMS) [C Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15040https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{D7A5D97F-8A57-4159-8882-08C793E64466}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
7013987An adult female Hawaiian bobtail squid, <em>Euprymna scolopes</em>, with its mantle cavity exposed from the underside. Some internal organs are visible, including the two lobes of the light organ that contains bioluminescent bacteria, <em>Vibrio fischeri</em>. The light organ includes accessory tissues like an ink sac (black) that serves as a shutter, and a silvery reflector that directs the light out of the underside of the animal.4/5/2024 8:00:36 PM4/5/2024 8:00:36 PMType    Name    Media Type    File Size    Modified We, the creators/owners of these images and videos, grant permission to post them in the NIGMS Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx11940https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{FE32D4A7-FB2E-4857-8370-2A6ECC0F717A}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
5825714A growing Vibrio cholerae (cholera) biofilm. Cholera bacteria form colonies called biofilms that enable them to resist antibiotic therapy within the body and other challenges to their growth. <br></br>Each slightly curved comma shape represents an individual bacterium from assembled confocal microscopy images. Different colors show each bacterium’s position in the biofilm in relation to the surface on which the film is growing. 3/3/2021 5:54:14 PM3/3/2021 5:54:14 PMType    Name    Media Type    File Size    Modified Jing_Bassler_biofilm    High 133 KB 3/3/2021 12:52 PM Walter, Taylor (NIH/NIGMS) [C Please let me know if you STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx12340https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{6EE99145-4496-41A4-ADB7-FB7D122F4F07}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
7019937The beating of cilia on the outside of the Hawaiian bobtail squid’s light organ concentrates <em>Vibrio fischeri</em> cells (green) present in the seawater into aggregates near the pore-containing tissue (red). From there, the bacterial cells (~2 mm) swim to the pores and migrate through a bottleneck into the interior crypts where a population of symbionts grow and remain for the life of the host. This image was taken using confocal fluorescence microscopy. <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=7016">7016</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=7017">7017</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=7018">7018</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=7020">7020</a>. 4/12/2024 1:10:43 PM4/12/2024 1:10:43 PMType    Name    Media Type    File Size    Modified Bacterial cells aggregated above a light-organ pore of the Hawaiian bobtail squid Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx11130https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{2C5419B0-60E3-46B8-8AEF-D8B7D119B757}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6808971Two fruit fly (<em>Drosophila melanogaster</em>) larvae brains with neurons expressing fluorescently tagged tubulin protein. Tubulin makes up strong, hollow fibers called microtubules that play important roles in neuron growth and migration during brain development. This image was captured using confocal microscopy, and the color indicates the position of the neurons within the brain.1/20/2022 7:49:11 PM1/20/2022 7:49:11 PMType    Name    Media Type    File Size    Modified Drosophila 3rd instar larval brain expressing neuronal tubulin-Wen Lu and Vladimir I. Gelfand_M    Medium 175 KB STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13650https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{8643DBC3-712E-4596-B178-AE3E38631BAB}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3574607Scientists have long known that multicellular organisms use biological molecules produced by one cell and sensed by another to transmit messages that, for instance, guide proper development of organs and tissues. But it's been a puzzle as to how molecules dumped out into the fluid-filled spaces between cells can precisely home in on their targets.<br> Using living tissue from fruit flies, a team led by Thomas Kornberg of the University of California, San Francisco, has shown that typical cells in animals can talk to each other via long, thin cell extensions called cytonemes (Latin for "cell threads") that may span the length of 50 or 100 cells. The point of contact between a cytoneme and its target cell acts as a communications bridge between the two cells.<br> More information about the research behind this image can be found in a <a href="http://biobeat.nigms.nih.gov/2014/02/animal-cells-reach-out-and-touch-to-communicate/" target=_blank>Biomedical Beat </a>Blog posting from February 2014.10/5/2020 5:54:08 AM10/5/2020 5:54:08 AMType    Name    Media Type    File Size    Modified Kornberg_cytonemes    High 265 KB 6/3/2016 3:32 PM aamishral2 (NIH/NIGMS) [C The point of contact between a STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13290https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{BCBF4841-8141-4D12-8A5C-3CC4EDA6C3C5}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2708490A blue laser beam turns on a protein that helps this human cancer cell move. Responding to the stimulus, the protein, called Rac1, first creates ruffles at the edge of the cell. Then it stretches the cell forward, following the light like a horse trotting after a carrot on a stick. This new light-based approach can turn Rac1 (and potentially many other proteins) on and off at exact times and places in living cells. By manipulating a protein that controls movement, the technique also offers a new tool to study embryonic development, nerve regeneration and cancer. Featured in the September 16, 2009, issue of <a href=http://publications.nigms.nih.gov/biobeat/09-09-16/index.html#1 target="_blank"><em>Biomedical Beat</em></a>.8/6/2020 4:31:43 PM8/6/2020 4:31:43 PMType    Name    Media Type    File Size    Modified a protein that controls movement, the technique also offers a new tool to study embryonic A blue laser beam turns on STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx12530https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{687A0EA7-3610-49D0-AED1-F7F73EBE909C}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
67551007Insect brains, like the honeybee brain shown here, are very different in shape from human brains. Despite that, bee and human brains have a lot in common, including many of the genes and neurochemicals they rely on in order to function. The bright-green spots in this image indicate the presence of tyrosine hydroxylase, an enzyme that allows the brain to produce dopamine. Dopamine is involved in many important functions, such as the ability to experience pleasure. This image was captured using confocal microscopy.9/23/2021 3:05:46 PM9/23/2021 3:05:46 PMType    Name    Media Type    File Size    Modified IGB Bee Brain Robinson Lab_M    Medium 545 KB 4/6/2021 12:27 PM Walter, Taylor (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx16440https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{A4B72739-220C-4865-ADD4-F79CA8848067}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
69271020The head of an axolotl—a type of salamander—that has been genetically modified so that its developing nervous system glows purple and its Schwann cell nuclei appear light blue. Schwann cells insulate and provide nutrients to peripheral nerve cells. Researchers often study axolotls for their extensive regenerative abilities. They can regrow tails, limbs, spinal cords, brains, and more. The researcher who took this image focuses on the role of the peripheral nervous system during limb regeneration. <Br><Br> This image was captured using a light sheet microscope. <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6928">6928</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6932">6932</a>. 3/28/2023 7:20:06 PM3/28/2023 7:20:06 PMType    Name    Media Type    File Size    Modified Axolotl Nervous System_M    Medium 421 KB 3/28/2023 9:59 AM Bigler, Abbey (NIH/NIGMS) [C Tools and Techniques STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx17260https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{18B0DBF0-DA94-4093-9314-DEBA854A5439}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6965980As this cell was undergoing cell division, it was imaged with two microscopy techniques: differential interference contrast (DIC) and confocal. The DIC view appears in blue and shows the entire cell. The confocal view appears in pink and shows the chromosomes.1/27/2023 9:51:37 PM1/27/2023 9:51:37 PMType    Name    Media Type    File Size    Modified An oblong blue shape with a with two different microscopy techniques: differential interference contrast (DIC) and STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx16230https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{CCDAC100-8DE1-4D58-8378-2F585CC18A16}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3741695The photo shows a confocal microscopy image of perineuronal nets (PNNs), which are specialized extracellular matrix (ECM) structures in the brain. The PNN surrounds some nerve cells in brain regions including the cortex, hippocampus and thalamus. Researchers study the PNN to investigate their involvement stabilizing the extracellular environment and forming nets around nerve cells and synapses in the brain. Abnormalities in the PNNs have been linked to a variety of disorders, including epilepsy and schizophrenia, and they limit a process called neural plasticity in which new nerve connections are formed. To visualize the PNNs, researchers labeled them with Wisteria floribunda agglutinin (WFA)-fluorescein. Related to <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3742">image 3742</a>.12/17/2020 5:33:10 PM12/17/2020 5:33:10 PMType    Name    Media Type    File Size    Modified Cortex_neuronal_ECM_L    Low 43 KB 6/3/2016 3:40 PM aamishral2 (NIH/NIGMS) [C TEM 5: Soleus muscle ECM on STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx18450https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{49BF2F89-C3EB-46DB-A682-8EF8BF979760}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131