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Current NIGMS Funding Opportunities
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6965
16688
As this cell was undergoing cell division, it was imaged with two microscopy techniques: differential interference contrast (DIC) and confocal. The DIC view appears in blue and shows the entire cell. The confocal view appears in pink and shows the chromosomes.
1/27/2023 9:51:37 PM
1/27/2023 9:51:37 PM
Type Name Media Type File Size Modified
An oblong blue shape with a
with two different microscopy
techniques
: differential interference contrast (DIC) and
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An image of <em>Caenorhabditis elegans</em>, a tiny roundworm, showing internal structures including the intestine, pharynx, and body wall muscle. <em>C. elegans</em> is one of the simplest organisms with a nervous system. Scientists use it to study nervous system development, among other things. This image was captured with quantitative orientation-independent differential interference contrast (OI-DIC) microscope. The scale bar is 100 µm. <Br><Br> More information about the microscopy that produced this image can be found in the <em>Journal of Microscopy</em> paper <a href="https://onlinelibrary.wiley.com/doi/10.1111/jmi.12682/">“An Orientation-Independent DIC Microscope Allows High Resolution Imaging of Epithelial Cell Migration and Wound Healing in a Cnidarian Model”</a> by Malamy and Shribak.
1/27/2023 9:45:39 PM
1/27/2023 9:45:39 PM
Type Name Media Type File Size Modified
Celegans Image Showing Organs_S Low 10 KB 1/27/2023 4:09 PM Bigler, Abbey (NIH/NIGMS
Tools and
Techniques
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Real-time footage of <em>Caenorhabditis elegans</em>, a tiny roundworm, trapped by a carnivorous fungus, <em>Arthrobotrys dactyloides</em>. This fungus makes ring traps in response to the presence of <em>C. elegans</em>. When a worm enters a ring, the trap rapidly constricts so that the worm cannot move away, and the fungus then consumes the worm. The size of the imaged area is 0.7mm x 0.9mm. <Br><Br> This video was obtained with a polychromatic polarizing microscope (PPM) in white light that shows the polychromatic birefringent image with hue corresponding to the slow axis orientation. More information about PPM can be found in the <em>Scientific Reports</em> paper <a href="https://www.nature.com/articles/srep17340/">“Polychromatic Polarization Microscope: Bringing Colors to a Colorless World”</a> by Shribak.
1/27/2023 9:47:31 PM
1/27/2023 9:47:31 PM
Type Name Media Type File Size Modified
Celegans in Fungus Image Thumbnail 670 KB 1/27/2023 4:37 PM Bigler, Abbey (NIH/NIGMS
Tools and
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A <em>Trigonium</em> diatom imaged by a quantitative orientation-independent differential interference contrast (OI-DIC) microscope. Diatoms are single-celled photosynthetic algae with mineralized cell walls that contain silica and provide protection and support. These organisms form an important part of the plankton at the base of the marine and freshwater food chains. The width of this image is 90 μm. <Br><Br> More information about the microscopy that produced this image can be found in the <em>Journal of Microscopy</em> paper <a href="https://onlinelibrary.wiley.com/doi/10.1111/jmi.12682/">“An Orientation-Independent DIC Microscope Allows High Resolution Imaging of Epithelial Cell Migration and Wound Healing in a Cnidarian Model”</a> by Malamy and Shribak.
1/27/2023 9:46:30 PM
1/27/2023 9:46:30 PM
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Trigonium_M Medium 692 KB 1/27/2023 4:29 PM Bigler, Abbey (NIH/NIGMS) [C
Br><Br> Would be the label-free image of
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A crawling cell with DNA shown in blue and actin filaments, which are a major component of the cytoskeleton, visible in pink. Actin filaments help enable cells to crawl. This image was captured using structured illumination microscopy.
1/27/2023 9:48:17 PM
1/27/2023 9:48:17 PM
Type Name Media Type File Size Modified
A Crawling Cell_M Medium 1083 KB 1/27/2023 4:43 PM Bigler, Abbey (NIH/NIGMS) [C
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6967
39002
A cancer cell with three nuclei, shown in light blue. The abnormal number of nuclei indicates that the cell failed to go through cell division, probably more than once. Mitochondria are shown in yellow, and a protein of the cell’s cytoskeleton appears in red. This video was captured using a confocal microscope.
1/27/2023 10:01:59 PM
1/27/2023 10:01:59 PM
Type Name Media Type File Size Modified
Multinucleated Cell Thumbnail Thumbnail 933 KB 1/27/2023 5:03 PM Bigler, Abbey (NIH/NIGMS) [C
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Melanoma (skin cancer) cells undergoing programmed cell death, also called apoptosis. This process was triggered by raising the pH of the medium that the cells were growing in. Melanoma in people cannot be treated by raising pH because that would also kill healthy cells. This video was taken using a differential interference contrast (DIC) microscope.
1/27/2023 9:56:19 PM
1/27/2023 9:56:19 PM
Type Name Media Type File Size Modified
Dying Melanoma Cells Thumbnail Thumbnail 807 KB 1/27/2023 4:57 PM Bigler, Abbey (NIH/NIGMS) [C
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This image is a computer-generated model of the approximately 4.2 million atoms of the HIV capsid, the shell that contains the virus' genetic material. Scientists determined the exact structure of the capsid and the proteins that it's made of using a variety of imaging techniques and analyses. They then entered these data into a supercomputer that produced the atomic-level image of the capsid. This structural information could be used for developing drugs that target the capsid, possibly leading to more effective therapies
8/31/2020 4:28:05 AM
8/31/2020 4:28:05 AM
Type Name Media Type File Size Modified
and the proteins that it's made of using a variety of imaging
techniques
and analyses
They then entered these data into a
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These images illustrate a technique combining cryo-electron tomography and super-resolution fluorescence microscopy called correlative imaging by annotation with single molecules (CIASM). CIASM enables researchers to identify small structures and individual molecules in cells that they couldn’t using older techniques.
12/22/2020 3:22:47 PM
12/22/2020 3:22:47 PM
Type Name Media Type File Size Modified
Figure_2_72dpi Thumbnail 63 KB 7/16/2020 3:27 PM Harris, Donald (NIH/NIGMS) [C
Tools and
Techniques
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In 2006, scientists developed an optical microscopy technique enabling them to clearly see individual molecules within cells. In 2007, they took the technique, abbreviated STORM, a step further. They identified multicolored probes that let them peer into cells and clearly see multiple cellular components at the same time, such as these microtubules (green) and small hollows called clathrin-coated pits (red). Unlike conventional methods, the multicolor STORM technique produces a crisp and high resolution picture. A sharper view of how cellular components interact will likely help scientists answer some longstanding questions about cell biology. Featured in the October 17, 2007, issue of <a href=http://publications.nigms.nih.gov/biobeat/07-10-17/#1 target="_blank"><em>Biomedical Beat</em></a>.
10/29/2020 2:02:16 PM
10/29/2020 2:02:16 PM
In 2006, scientists developed an optical microscopy
technique
enabling them to clearly see individual molecules within
Tools and
Techniques
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Details about the basic biology and chemistry of the ingredients that produce bioluminescence are allowing scientists to harness it as an imaging tool. Credit: Nathan Shaner, Scintillon Institute.<br></br> From Biomedical Beat article July 2017: <a href="https://biobeat.nigms.nih.gov/2017/07/chasing-fireflies-and-better-cellular-imaging-techniques/#more-4455">Chasing Fireflies—and Better Cellular Imaging Techniques</a>
3/1/2021 7:16:46 PM
3/1/2021 7:16:46 PM
Type Name Media Type File Size Modified
bioluminescent microcentrifuge tubes_M Medium 132 KB 7/21/2017 1:40 PM Varkala, Venkat (NIH/NIGMS) [C
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Real-time movie of young squids. Squids are often used as research organisms due to having the largest nervous system of any invertebrate, complex behaviors like instantaneous camouflage, and other unique traits. <Br><Br>This video was taken with polychromatic polarization microscope, as described in the <em>Scientific Reports</em> paper <a href=" https://www.nature.com/articles/srep17340/">“Polychromatic Polarization Microscope: Bringing Colors to a Colorless World”</a> by Shribak. The color is generated by interaction of white polarized light with the squid’s transparent soft tissue. The tissue works as a living tunable spectral filter, and the transmission band depends on the molecular orientation. When the young squid is moving, the tissue orientation changes, and its color shifts accordingly.
7/13/2022 8:02:15 PM
7/13/2022 8:02:15 PM
Type Name Media Type File Size Modified
Tools and
Techniques
https://www.nature.com/articles/srep17340 --this reference is just to show the
technique
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How far and fast an infectious disease spreads across a community depends on many factors, including transportation. These U.S. maps, developed as part of an international study to simulate and analyze disease spread, chart daily commuting patterns. They show where commuters live (top) and where they travel for work (bottom). Green represents the fewest number of people whereas orange, brown, and white depict the most. Such information enables researchers and policymakers to visualize how an outbreak in one area can spread quickly across a geographic region. Featured in the August 15, 2007, issue of <a href=http://publications.nigms.nih.gov/biobeat/07-08-15/#1 target="_blank"><em>Biomedical Beat</em></a>.
10/29/2020 1:48:39 PM
10/29/2020 1:48:39 PM
Type Name Media Type File Size Modified
2320_mappingdisease1_S Low 134 KB 3/29/2019 1:49 PM Constantinides, Stephen (NIH
Tools and
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This is a super-resolution LM image taken by Hiro Hakozaki and Masa Hoshijima of NCMIR. The image contains highlighted calcium channels in cardiac muscle using a technique called dSTORM. The microscope used in the NCMIR lab was built by Hiro Hakozaki.
12/23/2020 5:37:10 PM
12/23/2020 5:37:10 PM
Type Name Media Type File Size Modified
dSTORM_Cardiac1_L Low 131 KB 6/3/2016 3:27 PM aamishral2 (NIH/NIGMS) [C
Tools and
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This fingertip-shaped group of lights is a microscopic crystal called a quantum dot. About 10,000 times thinner than a sheet of paper, the dot radiates brilliant colors under ultraviolet light. Dots such as this one allow researchers to label and track individual molecules in living cells and may soon be used for speedy disease diagnosis, DNA testing, and screening for illegal drugs. Featured in the April 18, 2006, issue of <a href=http://publications.nigms.nih.gov/biobeat/06-04-18/ target="_blank"><em>Biomedical Beat</em></a>.
10/29/2020 2:26:34 PM
10/29/2020 2:26:34 PM
Type Name Media Type File Size Modified
tiny_points_of_light_M Medium 20 KB 6/3/2016 3:08 PM aamishral2 (NIH/NIGMS) [C
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A shell from the venomous cone snail <i>Conus omaria</i>, which lives in the Pacific and Indian oceans and eats other snails. University of Utah scientists discovered a new toxin in this snail species' venom, and say it will be a useful tool in designing new medicines for a variety of brain disorders, including Alzheimer's and Parkinson's diseases, depression, nicotine addiction and perhaps schizophrenia.
10/30/2020 4:26:56 PM
10/30/2020 4:26:56 PM
Type Name Media Type File Size Modified
cone_snail_1_S Low 47 KB 8/24/2016 5:34 PM Varkala, Venkat (NIH/NIGMS) [C
Tools and
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What looks like the gossamer wings of a butterfly is actually the retina of a mouse, delicately snipped to lay flat and sparkling with fluorescent molecules. The image is from a research project investigating the promise of gene therapy for glaucoma. It was created at an NIGMS-funded advanced microscopy facility that develops technology for imaging across many scales, from whole organisms to cells to individual molecules. <BR><BR> The ability to obtain high-resolution imaging of tissue as large as whole mouse retinas was made possible by a technique called large-scale mosaic confocal microscopy, which was pioneered by the NIGMS-funded National Center for Microscopy and Imaging Research. The technique is similar to Google Earth in that it computationally stitches together many small, high-resolution images. <BR><BR> More details: <BR><BR> Glaucoma is a progressive eye disease and the leading cause of irreversible blindness. It is characterized by the death of neurons in the retina called retinal ganglion cells. A number of studies over the past decade suggest that targeting these cells with gene therapy designed to prevent their death might slow the progression of glaucoma. <BR><BR> This study is investigating whether a non-disease-causing virus (adeno-associated virus serotype 2) can effectively deliver genes to retinal ganglion cells. The researchers introduced into the virus a gene for green fluorescent protein (GFP) so they could visualize how well the virus transduced the cells. <BR><BR> Two months after viral delivery of the fluorescent vector to the eyes of 7-month-old mice, the researchers examined the entire retinas of the subjects under a microscope. The ability to obtain high-resolution imaging of tissue as large as whole mouse retinas was made possible by a technique called large-scale mosaic confocal microscopy, which was pioneered by the NIGMS-funded National Center for Microscopy and Imaging Research. The technique is similar to Google Earth in that it computationally stitches together many small, high-resolution images. <BR><BR> The researchers observed GFP expression (yellow) in all parts of the retinal ganglion cells (blue), including the soma, axons and dendritic tree. These results suggest that a viral delivery system could deliver therapeutic genes to retinal ganglion cells for treating glaucoma and related diseases. <BR><BR> EQUIPMENT: Olympus FluoView™ FV1000 Confocal Microscope. Fluorophores: green fluorescent protein and Alexa Fluor 568. Non-glaucomatous DBA/2J-Gpnmb+ mice. <BR><BR> Reflecting on the work, the lead researcher [Keunyoung (“Christine”) Kim] says: “It is amazing to see intricate and artistically organized microscopic structures. … I encountered an entirely new world invisible to the naked eye—a galaxy of infinite secrets and endless potential for discovery.”
12/18/2020 8:02:50 PM
12/18/2020 8:02:50 PM
The
technique
is similar to Google Earth in that it computationally stitches together many
was made possible by a
technique
called large-scale mosaic confocal microscopy, which was
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See video with ID <a href=http://images.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2580><i>2580</i></a> in Image Gallery.
2/16/2021 10:15:43 PM
2/16/2021 10:15:43 PM
Type Name Media Type File Size Modified
These time series show the heart rates of four different individuals
Tools and
Techniques
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These six-month-old axolotls, a kind of salamander, glow green and blue under ultraviolet light. That's because they were genetically modified to make harmless green fluorescent protein, or GFP. Like X-ray vision, GFP lets you see inside the axolotls as they hang out in their aquarium. GFP not only can reveal internal structures in living organisms, but it also can light up specific cells and even proteins within a cell. That allows scientists to identify and track things like cancer cells. Featured in the November 18, 2009 issue of <a href=http://publications.nigms.nih.gov/biobeat/09-11-18/index.html#1 target="_blank"><i>Biomedical Beat</i></a>.
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The white circle in this image is a Petri dish, named for its inventor, Julius Richard Petri. These dishes are one of the most common pieces of equipment in biology labs, where researchers use them to grow cells.
3/24/2021 4:29:32 PM
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Molecular biologists are increasingly relying on bioinformatics software to visualize molecular interaction networks and to integrate these networks with data such as gene expression profiles. Related to <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2749">image 2749</a>.
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Irina Dementieva, a biochemist, and Youngchang Kim, a biophysicist and crystallographer, work with the first robot if its type in the U.S. to automate protein prufication. The robot, which is housed in a refrigerator, is an integral part of the Midwest Structural Genomics Center's plan to automate the protein crystallography process.
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This Petri dish contains microscopic roundworms called <i>Caenorhabditis elegans</i>. Researchers used these particular worms to study how <i>C. elegans</i> senses the color of light in its environment.
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Researchers doing behavioral experiments with honeybees sometimes use paint or enamel to give individual bees distinguishing marks. The elaborate social structure and impressive learning and navigation abilities of bees make them good models for behavioral and neurobiological research. Since the sequencing of the honeybee genome, published in 2006, bees have been used increasingly for research into the molecular basis for social interaction and other complex behaviors.
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This simulation of myosin V binding to actin was created using the software tool Protein Mechanica. With Protein Mechanica, researchers can construct models using information from a variety of sources: crystallography, cryo-EM, secondary structure descriptions, as well as user-defined solid shapes, such as spheres and cylinders. The goal is to enable experimentalists to quickly and easily simulate how different parts of a molecule interact.
8/21/2020 6:10:42 PM
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Student Christina Hueneke of the Midwest Center for Structural Genomics is overseeing a protein cloning robot. The robot was designed as part of an effort to exponentially increase the output of a traditional web lab. Part of the center's goal is to cut the average cost of analyzing a protein from $200,000 to $20,000 and to slash the average time from months to days and hours.
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Two cells over a 2-hour period. The one on the bottom left goes through programmed cell death, also known as apoptosis. The one on the top right goes through cell division, also called mitosis. This video was captured using a confocal microscope.
12/27/2021 4:57:37 PM
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A mouse's fat cells (red) are shown surrounded by a network of blood vessels (green). Fat cells store and release energy, protect organs and nerve tissues, insulate us from the cold and help us absorb important vitamins. This image is part of the Life: Magnified collection, which was displayed in the Gateway Gallery at Washington Dulles International Airport June 3, 2014, to January 21, 2015. To see all 46 images in this exhibit, go to https://www.nigms.nih.gov/education/life-magnified/Pages/default.aspx.
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This ACAPELLA robot for capillary protein crystallization grows protein crystals, freezes them, and centers them without manual intervention. The close-up is a view of one of the dispensers used for dispensing proteins and reagents.
10/29/2020 3:49:11 PM
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This image integrates the thousands of known molecular and genetic interactions happening inside our bodies using a computer program called Cytoscape. Images like this are known as network wiring diagrams, but Cytoscape creator Trey Ideker somewhat jokingly calls them "hairballs" because they can be so complicated, intricate and hard to tease apart. Cytoscape comes with tools to help scientists study specific interactions, such as differences between species or between sick and diseased cells. Related to <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2737">image 2737</a>. Featured in the June 16, 2010, issue of <a href=http://publications.nigms.nih.gov/biobeat/10-06-16/index.html#1 target="_blank"><em>Biomedical Beat</em></a>.
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These colorful, computer-generated ribbons show the backbone of a molecule that glows a fluorescent red. The molecule, called mStrawberry, was created by chemists based on a protein found in the ruddy lips of a coral. Scientists use the synthetic molecule and other "fruity" ones like it as a dye to mark and study cell structures. Featured in the April 18, 2007, issue of <a href=http://publications.nigms.nih.gov/biobeat/07-04-18/#1 target="_blank"><em>Biomedical Beat</em></a>.
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A research mentor (Lori Eidson) and student (Nina Waldron, on the microscope) were 2009 members of the BRAIN (Behavioral Research Advancements In Neuroscience) program at Georgia State University in Atlanta. This program is an undergraduate summer research experience funded in part by NIGMS.
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This image shows the hierarchical ontology of genes, cellular components and processes derived from large genomic datasets. From Dutkowski et al. <a href= "http://www.ncbi.nlm.nih.gov/pubmed/23242164" target="_blank">A gene ontology inferred from molecular networks </a>Nat Biotechnol. 2013 Jan;31(1):38-45. Related to <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3436">image 3436</a>.
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Two mouse fibroblasts, one of the most common types of cells in mammalian connective tissue. They play a key role in wound healing and tissue repair. This image was captured using structured illumination microscopy.
12/27/2021 4:20:11 PM
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The two large, central, round shapes are ovaries from a typical fruit fly (<em>Drosophila melanogaster</em>). The small butterfly-like structures surrounding them are fruit fly ovaries where researchers suppressed the expression of a gene that controls microtubule polymerization and is necessary for normal development. This image was captured using a confocal laser scanning microscope. <Br><Br> Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6807">6807</a>.
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Established in 1953, the Coriell Institute for Medical Research distributes cell lines and DNA samples to researchers around the world. Shown here are Coriell's cryogenic tanks filled with liquid nitrogen and millions of vials of frozen cells.
8/6/2020 6:16:05 PM
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This slide shows the technologies that the Joint Center for Structural Genomics developed for going from gene to structure and how the technologies have been integrated into a high-throughput pipeline, including all of the steps from target selection, parallel expression, protein purification, automated crystallization trials, automated crystal screening, structure determination, validation, and publication.
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This image shows the hierarchical ontology of genes, cellular components and processes derived from large genomic datasets. From Dutkowski et al. <a href= "http://www.ncbi.nlm.nih.gov/pubmed/23242164" target="_blank">A gene ontology inferred from molecular networks </a>Nat Biotechnol. 2013 Jan;31(1):38-45. Related to <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3437">image 3437</a>.
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The marine bacterium <i>Vibrio harveyi</i> glows when near its kind. This luminescence, which results from biochemical reactions, is part of the chemical communication used by the organisms to assess their own population size and distinguish themselves from other types of bacteria. But <i>V. harveyi</i> only light up when part of a large group. This communication, called quorum sensing, speaks for itself here on a lab dish, where more densely packed areas of the bacteria show up blue. Other types of bacteria use quorum sensing to release toxins, trigger disease, and evade the immune system. Featured in the September 20, 2005, issue of <a href=http://publications.nigms.nih.gov/biobeat/05-09-20/#1 target="_blank"><em>Biomedical Beat</em></a>.
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This animation shows atoms of the HIV capsid, the shell that encloses the virus's genetic material. Scientists determined the exact structure of the capsid using a variety of imaging techniques and analyses. They then entered this data into a supercomputer to produce this image. Learn more in the <a href="https://www.nigms.nih.gov/education/pages/Factsheet_StructuralBiology.aspx"> structural biology fact sheet</a>. Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=3477">3477</a>.
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Many researchers use the mouse <i>(Mus musculus)</i> as a model organism to study mammalian biology. Mice carry out practically all the same life processes as humans and, because of their small size and short generation times, are easily raised in labs. Scientists studying a certain cellular activity or disease can choose from tens of thousands of specially bred strains of mice to select those prone to developing certain tumors, neurological diseases, metabolic disorders, premature aging, or other conditions.
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Microarrays, also called gene chips, are tools that let scientists track the activity of hundreds or thousands of genes simultaneously. For example, researchers can compare the activities of genes in healthy and diseased cells, allowing the scientists to pinpoint which genes and cell processes might be involved in the development of a disease.
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The intense X-rays produced by synchrotrons such as the Advanced Photon Source are ideally suited for protein structure determination. Using synchrotron X-rays and advanced computers scientists can determine protein structures at a pace unheard of decade ago.
10/29/2020 4:00:37 PM
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Under the microscope, an <i>E. coli</i> cell lights up like a fireball. Each bright dot marks a surface protein that tells the bacteria to move toward or away from nearby food and toxins. Using a new imaging technique, researchers can map the proteins one at a time and combine them into a single image. This lets them study patterns within and among protein clusters in bacterial cells, which don't have nuclei or organelles like plant and animal cells. Seeing how the proteins arrange themselves should help researchers better understand how cell signaling works. A movie containing this image was featured in the August 19, 2009, issue of <a href=http://publications.nigms.nih.gov/biobeat/09-08-19/index.html#1 target="_blank"><em>Biomedical Beat</em></a>.
8/28/2020 5:59:20 PM
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In the determination of protein structures by X-ray crystallography, this unique soft (l = 2.29Å) X-ray source is used to collect anomalous scattering data from protein crystals containing light atoms such as sulfur, calcium, zinc and phosphorous. This data can be used to image the protein.
10/29/2020 4:05:09 PM
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Using a supercomputer to simulate the movement of atoms in a ribosome, researchers looked into the core of this protein-making nanomachine and took snapshots. The picture shows an amino acid (green) being delivered by transfer RNA (yellow) into a corridor (purple) in the ribosome. In the corridor, a series of chemical reactions will string together amino acids to make a protein. The research project, which tracked the movement of more than 2.6 million atoms, was the largest computer simulation of a biological structure to date. The results shed light on the manufacturing of proteins and could aid the search for new antibiotics, which typically work by disabling the ribosomes of bacteria. Featured in the November 15, 2005, issue of <a href=http://publications.nigms.nih.gov/biobeat/05-11-15/#1 target="_blank"><em>Biomedical Beat</em></a>.
10/29/2020 2:33:42 PM
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The HIV capsid is pear-shaped structure that is made of proteins the virus needs to mature and become infective. The capsid is inside the virus and delivers the virus' genetic information into a human cell. To better understand how the HIV capsid does this feat, scientists have used computer programs to simulate its assembly. This image shows a series of snapshots of the steps that grow the HIV capsid. A model of a complete capsid is shown on the far right of the image for comparison; the green, blue and red colors indicate different configurations of the capsid protein that make up the capsid “shell.” The bar in the left corner represents a length of 20 nanometers, which is less than a tenth the size of the smallest bacterium. Computer models like this also may be used to reconstruct the assembly of the capsids of other important viruses, such as Ebola or the Zika virus. <br><br> The studies reporting this research were published in <a href="http://www.nature.com/ncomms/2016/160513/ncomms11568/full/ncomms11568.html"><i>Nature Communications</i></a> and <a href="http://www.nature.com/nature/journal/v469/n7330/full/nature09640.html"><i>Nature</i></a>. <br><br> To learn more about how researchers used computer simulations to track the assembly of the HIV capsid, see <a href=" https://news.uchicago.edu/article/2016/06/14/simulations-describe-hivs-diabolical-delivery-device">this press release from the University of Chicago</a>.
12/18/2020 4:10:47 PM
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HIV capsid synthesis 222px_TransparentBackground-1_S Thumbnail 127 KB 3/20/2017 9:21 AM Machalek, Alisa
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Originally from the waters of India, Nepal and neighboring countries, zebrafish can now be found swimming in science labs (and home aquariums) throughout the world. This fish is a favorite study subject for scientists interested in how genes guide the early stages of prenatal development (including the developing fin shown here) and in the effects of environmental contamination on embryos.<Br><Br> In this image, green fluorescent protein (GFP) is expressed where the gene sox9b is expressed. Collagen (red) marks the fin rays, and DNA, stained with a dye called DAPI, is in blue. sox9b plays many important roles during development, including the building the heart and brain and is also necessary for skeletal development. At the University of Wisconsin, researchers have found that exposure to contaminants that bind the aryl-hydrocarbon receptor results in the downregulation of sox9b. Loss of sox9b severely disrupts development in zebrafish and causes a life-threatening disorder called campomelic dysplasia (CD) in humans. CD is characterized by cardiovascular, neural and skeletal defects. By studying the roles of genes such as sox9b in zebrafish, scientists hope to better understand normal development in humans as wells as how to treat developmental disorders and diseases.<Br><Br> This image is part of the Life: Magnified collection, which was displayed in the Gateway Gallery at Washington Dulles International Airport June 3, 2014, to January 21, 2015. To see all 46 images in this exhibit, to <a href="https://www.nigms.nih.gov/education/life-magnified/Pages/default.aspx">click here</a>.
11/28/2022 9:23:03 PM
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A blue laser beam turns on a protein that helps this human cancer cell move. Responding to the stimulus, the protein, called Rac1, first creates ruffles at the edge of the cell. Then it stretches the cell forward, following the light like a horse trotting after a carrot on a stick. This new light-based approach can turn Rac1 (and potentially many other proteins) on and off at exact times and places in living cells. By manipulating a protein that controls movement, the technique also offers a new tool to study embryonic development, nerve regeneration and cancer. Featured in the September 16, 2009, issue of <a href=http://publications.nigms.nih.gov/biobeat/09-09-16/index.html#1 target="_blank"><em>Biomedical Beat</em></a>.
8/6/2020 4:31:43 PM
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a protein that controls movement, the
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A blue laser beam turns on
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Three fruit fly (<em>Drosophila melanogaster</em>) ovarioles (yellow, blue, and magenta) with egg cells visible inside them. Ovarioles are tubes in the reproductive systems of female insects. Egg cells form at one end of an ovariole and complete their development as they reach the other end, as shown in the yellow wild-type ovariole. This process requires an important protein that is missing in the blue and magenta ovarioles. This image was created using confocal microscopy. <Br><Br> More information on the research that produced this image can be found in the <em> Current Biology</em> paper <a href="https://www.cell.com/current-biology/fulltext/S0960-9822(21)00669-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0960982221006692%3Fshowall%3Dtrue">“Gatekeeper function for Short stop at the ring canals of the <em>Drosophila</em> ovary”</a> by Lu et al.
1/21/2022 3:51:54 PM
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This page last reviewed on 12/30/2018 11:48 PM