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3438593The chemical structure of the morphine molecule8/22/2020 4:44:39 PM8/22/2020 4:44:39 PMMorphine_structure__thumbnail_    Thumbnail 2 KB 6/3/2016 3:29 PM aamishral2 (NIH Morphine_structure_L    High 4772 KB 6/3/2016 3:29 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15400https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{6EE205B7-C53B-4A56-B1E5-DB767CF5273F}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2342308X-ray structure of a new DNA repair enzyme superfamily representative from the human gastrointestinal bacterium <i>Enterococcus faecalis</i>. European scientists used this structure to generate homologous structures. Featured as the May 2007 Protein Structure Initiative Structure of the Month.10/29/2020 2:46:36 PM10/29/2020 2:46:36 PMEuropean scientists used this structure to generate homologous structures Featured as the May 2007 Protein Structure Initiative Structure of the Month STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx17200https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{985DEF74-B19F-428E-A73F-96B3A80C5557}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2363181The goal of the PSI is to determine the three-dimensional shapes of a wide range of proteins by solving the structures of representative members of each protein family found in nature. The collection of structures should serve as a valuable resource for biomedical research scientists.10/29/2020 4:12:18 PM10/29/2020 4:12:18 PMhi_gene_to_structure_M    Medium 17 KB 6/3/2016 3:09 PM aamishral2 (NIH/NIGMS) [C The collection of structures should serve as a valuable resource for biomedical research STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx17500https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{5707B2E3-09B2-4FAE-824E-FD8FD64AF328}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2343309This crystal structure shows a conserved hypothetical protein from <i>Mycobacterium tuberculosis</i>. Only 12 other proteins share its sequence homology, and none has a known function. This structure indicates the protein may play a role in metabolic pathways. Featured as one of the August 2007 Protein Structure Initiative Structures of the Month.10/29/2020 2:48:36 PM10/29/2020 2:48:36 PMThis structure indicates the protein may play a role in metabolic pathways Featured as one of the August 2007 Protein Structure Initiative Structures of the Month STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx64900https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{C049B741-42A1-4298-8E5F-15EE784B48B7}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2337112Crystal structure of the beta2-adrenergic receptor protein. This is the first known structure of a human G protein-coupled receptor, a large family of proteins that control critical bodily functions and the action of about half of today's pharmaceuticals. Featured as one of the November 2007 Protein Structure Initiative Structures of the Month.10/29/2020 2:35:50 PM10/29/2020 2:35:50 PMType    Name    Media Type    File Size    Modified 2337_beta2-adrenergic_T    Thumbnail 108 KB 3/29/2019 1:47 PM Constantinides, Stephen Molecular Structures STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx16300https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{55028E4D-1BE0-45A9-BB7C-A6F9AA03316D}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2339114NMR solution structure of a plant protein that may function in host defense. This protein was expressed in a convenient and efficient wheat germ cell-free system. Featured as the June 2007 Protein Structure Initiative Structure of the Month.10/29/2020 2:40:04 PM10/29/2020 2:40:04 PMType    Name    Media Type    File Size    Modified Featured as the June 2007 Protein Structure Initiative Structure of the Month Molecular Structures STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx16500https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{47234FEB-EE1D-4DF6-A666-446A5C2D9E37}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6601904This animation shows atoms of the HIV capsid, the shell that encloses the virus's genetic material. Scientists determined the exact structure of the capsid using a variety of imaging techniques and analyses. They then entered this data into a supercomputer to produce this image. Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=3477">3477</a>. 11/14/2023 1:23:27 PM11/14/2023 1:23:27 PMAtomic-Level Structure of the HIV Capsid    High 20229 KB 12/10/2020 5:41 PM atomic-level structure of HIV capsid_thumbnail    Thumbnail 12 KB 12/10/2020 STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx17200https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{2C77B30F-B214-4301-B475-E0433A651C12}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2340115This is the first structure of a protein derived from the metagenomic sequences collected during the Sorcerer II Global Ocean Sampling project. The crystal structure shows a barrel protein with a ferredoxin-like fold and a long chain fatty acid in a deep cleft (shaded red). Featured as one of the August 2007 Protein Structure Initiative Structures of the Month.10/29/2020 2:41:27 PM10/29/2020 2:41:27 PMType    Name    Media Type    File Size    Modified 2340_jcsg20d6_S    Low 79 KB 3/29/2019 1:45 PM Constantinides, Stephen (NIH/NIGMS) [C Molecular Structures STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15800https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{306636AD-6984-4103-B367-87B1EB3474FA}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2372117Crystal structure of a protein with unknown function from <i>Xanthomonas campestris</i>, a plant pathogen. Eight copies of the protein crystallized to form a ring. Chosen as the December 2007 Protein Structure Initiative Structure of the Month.10/29/2020 4:26:44 PM10/29/2020 4:26:44 PMType    Name    Media Type    File Size    Modified Chosen as the December 2007 Protein Structure Initiative Structure of the Month Molecular Structures STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13900https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{87B885D1-27EB-4EB7-8EEB-FFD75998D185}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2365183A global "map of the protein structure universe." The Berkeley Structural Genomics Center has developed a method to visualize the vast universe of protein structures in which proteins of similar structure are located close together and those of different structures far away in the space. This map, constructed using about 500 of the most common protein folds, reveals a highly non-uniform distribution, and shows segregation between four elongated regions corresponding to four different protein classes (shown in four different colors). Such a representation reveals a high-level of organization of the protein structure universe.10/29/2020 4:16:23 PM10/29/2020 4:16:23 PMa representation reveals a high-level of organization of the protein structure universe Map of protein structures 01 Molecular Structures STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx16600https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{2388E2EB-3730-4F33-A049-087CFC2A4AFF}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2373118Crystal structure of oligoendopeptidase F, a protein slicing enzyme from <i>Bacillus stearothermophilus</i>, a bacterium that can cause food products to spoil. The crystal was formed using a microfluidic capillary, a device that enables scientists to independently control the parameters for protein crystal nucleation and growth. Featured as one of the July 2007 Protein Structure Initiative Structures of the Month.10/29/2020 4:30:39 PM10/29/2020 4:30:39 PMType    Name    Media Type    File Size    Modified Technologies Center for Gene to 3D Structure/Midwest Center for Structural Genomics Molecular Structures STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15000https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{0D97FDE5-F4E0-4172-A7C4-8FCFDBC60F26}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2748559This ribbon drawing of a protein hand drawn and colored by researcher Jane Richardson in 1981 helped originate the ribbon representation of proteins that is now ubiquitous in molecular graphics. The drawing shows the 3-dimensional structure of the protein triose phosphate isomerase. The green arrows represent the barrel of eight beta strands in this structure and the brown spirals show the protein's eight alpha helices. A black and white version of this drawing originally illustrated a <a href=http://kinemage.biochem.duke.edu/teaching/anatax target="_blank">review article</a> in <i>Advances in Protein Chemistry</i>, volume 34, titled "Anatomy and Taxonomy of Protein Structures." The illustration was selected as Picture of The Day on the English Wikipedia for November 19, 2009. Other important and beautiful images of protein structures by Jane Richardson are available in her <a href=http://commons.wikimedia.org/wiki/User:Dcrjsr/gallery_of_protein_structure target="_blank">Wikimedia gallery</a>.8/18/2020 7:55:11 PM8/18/2020 7:55:11 PMThe drawing shows the 3-dimensional structure of the protein triose phosphate isomerase barrel of eight beta strands in this structure and the brown spirals show the protein's STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx14300https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{463859B2-279A-4E80-A85C-A2382E815BD5}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3314448Opioid receptors on the surfaces of brain cells are involved in pleasure, pain, addiction, depression, psychosis, and other conditions. The receptors bind to both innate opioids and drugs ranging from hospital anesthetics to opium. Researchers at The Scripps Research Institute, supported by the NIGMS Protein Structure Initiative, determined the first three-dimensional structure of a human opioid receptor, a kappa-opioid receptor. In this illustration, the submicroscopic receptor structure is shown while bound to an agonist (or activator). The structure is superimposed on a poppy flower, the source of opium. From a Scripps Research Institute <a href=http://www.scripps.edu/news/press/20120321stevens.html target="_blank">news release</a>.12/23/2020 4:46:54 PM12/23/2020 4:46:54 PMby the NIGMS Protein Structure Initiative, determined the first three-dimensional structure of a human opioid receptor, a Human opioid receptor structure superimposed on poppy STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx14400https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{4BBF8D4D-E333-41E5-9B54-06A7AA38E085}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3487664A special "messy" region of a potassium ion channel is important in its function.9/8/2020 10:55:58 PM9/8/2020 10:55:58 PMBK_Virtual_structure_M    Medium 253 KB 9/8/2020 6:52 PM Harris, Donald (NIH/NIGMS BK_Virtual_structure_thumbnail    Thumbnail 2 KB 9/8/2020 6:52 PM Harris, Donald STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15600https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{801B3D99-3943-4B03-9CF6-04BD027510D7}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2355246Model of the enzyme Nicotinic acid phosphoribosyltransferase. This enzyme, from the archaebacterium, <i>Pyrococcus furiosus</i>, is expected to be structurally similar to a clinically important human protein called B-cell colony enhancing factor based on amino acid sequence similarities and structure prediction methods. The structure consists of identical protein subunits, each shown in a different color, arranged in a ring.10/29/2020 3:44:23 PM10/29/2020 3:44:23 PMfactor based on amino acid sequence similarities and structure prediction methods The structure consists of identical protein subunits, each shown in a different color STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx17400https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{32F0F10A-7087-466D-BEE4-36238144FEC6}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2345310Structure of a magnesium transporter protein from an antibiotic-resistant bacterium (<i>Enterococcus faecalis</i>) found in the human gut. Featured as one of the June 2007 Protein Sructure Initiative Structures of the Month.10/29/2020 2:58:36 PM10/29/2020 2:58:36 PMType    Name    Media Type    File Size    Modified 2345_nysgrc0618071_thumbnail    Thumbnail 83 KB 3/4/2019 3:32 PM Constantinides, Stephen Molecular Structures STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15700https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{DE4E47B3-0D83-483C-AC65-F8FE6D24E0B1}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2367184A global "map of the protein structure universe" indicating the positions of specific proteins. The preponderance of small, less-structured proteins near the origin, with the more highly structured, large proteins towards the ends of the axes, may suggest the evolution of protein structures.10/29/2020 4:18:37 PM10/29/2020 4:18:37 PMType    Name    Media Type    File Size    Modified hi_map500examples_L    Low 82 KB 6/3/2016 3:09 PM aamishral2 (NIH/NIGMS) [C Molecular Structures STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx14900https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{8B5616E0-C0D5-468B-ACDC-A2D314BF8A73}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2351243An NMR solution structure model of the transfer RNA splicing enzyme endonuclease in humans (subunit Sen15). This represents the first structure of a eukaryotic tRNA splicing endonuclease subunit.10/29/2020 3:06:53 PM10/29/2020 3:06:53 PMType    Name    Media Type    File Size    Modified 2351_hi_2gw6_S    Low 93 KB 3/29/2019 11:48 AM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15200https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{95C0D2AD-AB59-4100-83B0-78CA3F50C76E}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3307445A study published in March 2012 used cryo-electron microscopy to determine the structure of the DNA replication origin recognition complex (ORC), a semi-circular, protein complex (yellow) that recognizes and binds DNA to start the replication process. The ORC appears to wrap around and bend approximately 70 base pairs of double stranded DNA (red and blue). Also shown is the protein Cdc6 (green), which is also involved in the initiation of DNA replication. The video shows the structure from different angles. From a Brookhaven National Laboratory <a href=http://www.bnl.gov/bnlweb/pubaf/pr/PR_display.asp?prID=1391&template=Today target="_blank">news release</a>, "Study Reveals How Protein Machinery Binds and Wraps DNA to Start Replication." See related image <a href=http://images.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3597><i>3597</i></a>.12/22/2020 11:01:10 PM12/22/2020 11:01:10 PMThe light brown shading represents the structure obtained by cryo-EM The ribbon diagram structures came from X-ray crystallography and were superimposed on the cryo-EM structure STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx16000https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{4E2A15E1-0A1E-4F7D-9AE7-49FFE5103E20}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3660687Ribbon diagram showing the structure of Ribonuclease P with tRNA.2/4/2020 8:55:06 PM2/4/2020 8:55:06 PMType    Name    Media Type    File Size    Modified Ribonuclease_P    High 468 KB 6/3/2016 3:38 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13700https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{97A0FB19-2CBE-4253-A201-601EC0520575}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2508204Proteins are made of amino acids hooked end-to-end like beads on a necklace. To become active, proteins must twist and fold into their final, or "native," conformation." A protein's final shape enables it to accomplish its function. Featured in <a href=http://publications.nigms.nih.gov/structlife/ target="_blank"><i>The Structures of Life</i></a>.5/13/2024 6:21:12 PM5/13/2024 6:21:12 PM/education/Booklets/The-Structures-of-Life/Pages/Home.aspx"><em>The Structures of Life</em The Structures of Life page 3 Molecular Structures structure STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15200https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{975CBFB7-871F-4D5C-8451-06C1200425BA}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2338113Model of a member from the Tex protein family, which is implicated in transcriptional regulation and highly conserved in eukaryotes and prokaryotes. The structure shows significant homology to a human transcription elongation factor that may regulate multiple steps in mRNA synthesis.10/29/2020 2:37:40 PM10/29/2020 2:37:40 PMType    Name    Media Type    File Size    Modified burleyd    Thumbnail 7 KB 6/3/2016 3:09 PM aamishral2 (NIH/NIGMS) [C Molecular Structures protein structure STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx17200https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{35294316-7B85-4707-83F4-B824CBA718BB}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2341307Model of the enzyme aminopeptidase N from the human pathogen <i>Neisseria meningitidis</i>, which can cause meningitis epidemics. The structure provides insight on the active site of this important molecule.10/29/2020 2:43:00 PM10/29/2020 2:43:00 PMType    Name    Media Type    File Size    Modified 2341_joachimiak1_S    Low 133 KB 3/29/2019 1:43 PM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx18900https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{C0E3C41D-D8EA-4EB0-92FA-CC970965AA6B}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3597739A study published in March 2012 used cryo-electron microscopy to determine the structure of the DNA replication origin recognition complex (ORC), a semi-circular, protein complex (yellow) that recognizes and binds DNA to start the replication process. The ORC appears to wrap around and bend approximately 70 base pairs of double stranded DNA (red and blue). Also shown is the protein Cdc6 (green), which is also involved in the initiation of DNA replication. Related to video <a href=http://images.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3307><i>3307</i></a> that shows the structure from different angles. From a Brookhaven National Laboratory <a href=http://www.bnl.gov/bnlweb/pubaf/pr/PR_display.asp?prID=1391&template=Today target="_blank">news release</a>, "Study Reveals How Protein Machinery Binds and Wraps DNA to Start Replication." 10/8/2024 1:27:54 PM10/8/2024 1:27:54 PMThe light brown shading represents the structure obtained by cryo-EM The ribbon diagram structures came from X-ray crystallography and were superimposed on the cryo-EM structure STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx43500https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{B3B34891-56E7-4C4C-AC4A-53B710F155A1}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2378123Model of a protein, antigen 85B, that is the most abundant protein exported by <i>Mycobacterium tuberculosis</i>, which causes most cases of tuberculosis. Antigen 85B is involved in building the bacterial cell wall and is an attractive drug target. Based on its structure, scientists have suggested a new class of antituberculous drugs.10/29/2020 4:41:39 PM10/29/2020 4:41:39 PMType    Name    Media Type    File Size    Modified Molecular Structures drug development, model, protein structure string;#<DIV><img style='max-width:100px;max-height STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15400https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{B2306E63-5526-4111-87D2-099B1DDC2FD0}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2386322Structure of sortase b from the bacterium <i>B. anthracis</i>, which causes anthrax. Sortase b is an enzyme used to rob red blood cells of iron, which the bacteria need to survive.10/29/2020 4:53:35 PM10/29/2020 4:53:35 PMType    Name    Media Type    File Size    Modified hi_Sortase_b_from_B_anthracis_L    Low 30 KB 6/3/2016 3:10 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx12000https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{D46B5EDD-4F22-43BF-A896-E9934976DE8C}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
5874840Cryo-electron microscopy (cryo-EM) has the power to capture details of proteins and other small biological structures at the molecular level.&nbsp; This image shows proteins in the capsid, or outer cover, of bacteriophage P22, a virus that infects the Salmonella bacteria.&nbsp; Each color shows the structure and position of an individual protein in the capsid.&nbsp; Thousands of cryo-EM scans capture the structure and shape of all the individual proteins in the capsid and their position relative to other proteins. A computer model combines these scans into the 3-dimension image shown here.&nbsp; Related to image <a href="/Pages/DetailPage.aspx?imageID2=5875">5875</a>.12/18/2020 9:09:51 PM12/18/2020 9:09:51 PMEach color shows the structure and position of an individual protein in the capsid Thousands of cryo-EM scans capture the structure and shape of all the individual proteins STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx14500https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{B795949D-2B81-40F1-A108-BA57CBB23572}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2346311Model of a human protein associated with the adenylyl cyclase, an enzyme involved in intracellular signaling.10/29/2020 3:00:19 PM10/29/2020 3:00:19 PMType    Name    Media Type    File Size    Modified 2346_th_1k8f_S    Low 53 KB 3/29/2019 11:50 AM Constantinides, Stephen (NIH/NIGMS) [C protein structure STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx14500https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{B6534242-F2E6-4D37-8A57-C9F8F5724860}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2388252Solution NMR structure of protein target WR41 (left) from <i>C. elegans</i>. Noting the unanticipated structural similarity to the ubiquitin protein (Ub) found in all eukaryotic cells, researchers discovered that WR41 is a Ub-like modifier, ubiquitin-fold modifier 1 (Ufm1), on a newly uncovered ubiquitin-like pathway. Subsequently, the PSI group also determined the three-dimensional structure of protein target HR41 (right) from humans, the E2 ligase for Ufm1, using both NMR and X-ray crystallography.10/29/2020 4:56:46 PM10/29/2020 4:56:46 PMType    Name    Media Type    File Size    Modified 2388_wr_hr41_S    Low 63 KB 3/29/2019 11:29 AM Constantinides, Stephen (NIH/NIGMS) [C Molecular Structures STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx384800https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{9831464C-3582-4504-A4D7-DFC565D64ADE}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2385321Model based on X-ray crystallography of the structure of a small heat shock protein complex from the bacteria, <i>Methanococcus jannaschii</i>. <i>Methanococcus jannaschii</i> is an organism that lives at near boiling temperature, and this protein complex helps it cope with the stress of high temperature. Similar complexes are produced in human cells when they are "stressed" by events such as burns, heart attacks, or strokes. The complexes help cells recover from the stressful event.10/29/2020 4:52:21 PM10/29/2020 4:52:21 PMType    Name    Media Type    File Size    Modified hi_shsp_M    Medium 33 KB 6/3/2016 3:10 PM aamishral2 (NIH/NIGMS) [C Molecular Structures protein structure STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13300https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{40B67A58-1E58-4090-86D8-6F853DE4D2BA}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2426327The structure of a gene-regulating zinc finger protein bound to DNA.8/17/2020 9:31:43 PM8/17/2020 9:31:43 PMType    Name    Media Type    File Size    Modified DesignedZF    High 595 KB 6/3/2016 3:10 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15000https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{05B06D12-30DC-46F0-97A0-41AAFF3B328B}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3758824Dengue virus is a mosquito-borne illness that infects millions of people in the tropics and subtropics each year. Like many viruses, dengue is enclosed by a protective membrane. The proteins that span this membrane play an important role in the life cycle of the virus. Scientists used cryo-EM to determine the structure of a dengue virus at a 3.5-angstrom resolution to reveal how the membrane proteins undergo major structural changes as the virus matures and infects a host. The image shows a side view of the structure of a protein composed of two smaller proteins, called E and M. Each E and M contributes two molecules to the overall protein structure (called a heterotetramer), which is important for assembling and holding together the viral membrane, i.e., the shell that surrounds the genetic material of the dengue virus. The dengue protein's structure has revealed some portions in the protein that might be good targets for developing medications that could be used to combat dengue virus infections. To learn more about cryo-EM, see the blog post <a href="https://biobeat.nigms.nih.gov/2016/02/cryo-electron-microscopy-reveals-molecules-in-ever-greater-detail/">Cryo-Electron Microscopy Reveals Molecules in Ever Greater Detail.</a> For a video of the entire virus rotating, see <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3748"> video 3748</a>, and for a still image of the virus, see <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3756">image 3756</a>.12/17/2020 6:24:54 PM12/17/2020 6:24:54 PMThe image shows a side view of the structure of a protein composed of two smaller proteins about the video of the dengue virus structure you had determined by cryo-EM and which is STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13600https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{CBF115CF-91A9-47A3-81F0-0C4CDB1F4451}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3584797This image shows a computer-generated, three-dimensional map of the rotavirus structure. This virus infects humans and other animals and causes severe diarrhea in infants and young children. By the age of five, almost every child in the world has been infected with this virus at least once. Scientists have found a vaccine against rotavirus, so in the United States there are very few fatalities, but in developing countries and in places where the vaccine is unavailable, this virus is responsible for more than 450,000 deaths each year.<Br><Br> The rotavirus comprises three layers: the outer, middle and inner layers. On infection, the outer layer is removed, leaving behind a "double-layered particle." Researchers have studied the structure of this double-layered particle with a transmission electron microscope. Many images of the virus at a magnification of ~50,000x were acquired, and computational analysis was used to combine the individual particle images into a three-dimensional reconstruction. <Br><Br>The image was rendered by Melody Campbell (PhD student at TSRI). Work that led to the 3D map was published in Campbell et al. Movies of ice-embedded particles enhance resolution in electron cryo-microscopy. Structure. 2012;20(11):1823-8. PMCID: PMC3510009. <Br><Br>This image was part of the Life: Magnified collection, which was displayed in the Gateway Gallery at Washington Dulles International Airport June 3, 2014, to January 21, 2015. To see all 46 images in this exhibit, go to https://www.nigms.nih.gov/education/life-magnified/Pages/default.aspx.2/28/2024 4:48:57 PM2/28/2024 4:48:57 PMResearchers have studied the structure of this double-layered particle with a transmission This image shows a computer-generated, three-dimensional map of the rotavirus structure STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13600https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{38997347-01E8-4B63-97E7-3CD152CD4331}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2488332The structure of the pore-forming protein VDAC-1 from humans. This molecule mediates the flow of products needed for metabolism--in particular the export of ATP--across the outer membrane of mitochondria, the power plants for eukaryotic cells. VDAC-1 is involved in metabolism and the self-destruction of cells--two biological processes central to health. Relates to a <a href=http://www.nigms.nih.gov/News/Results/20080904_announce.htm target="_blank">September 4, 2008 news release</a>.5/9/2022 1:31:21 PM5/9/2022 1:31:21 PMThe structure of the pore-forming protein VDAC-1 from humans Hi Alisa, of course it is also can send you a movie with a rotating structure but this would be about 23 MB. May be STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx12600https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{13FC4ED3-B1D0-44C3-A5F6-D4DA2EC19518}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3459726Scientists recently discovered the full molecular structure of telomerase, an enzyme important to aging and cancer. Within each cell, telomerase maintains the telomeres, or end pieces, of a chromosome, preserving genetic data and extending the life of the cell. In their study, a team from UCLA and UC Berkeley found the subunit p50, shown in red, to be a keystone in the enzyme's structure and function. Featured in the May 16, 2013 issue of <em><a href="http://publications.nigms.nih.gov/biobeat/#4">Biomedical Beat</a></em>.8/22/2020 7:23:08 PM8/22/2020 7:23:08 PMthe subunit p50, shown in red, to be a keystone in the enzyme's structure and function Molecular Structures STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx12400https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{D7B54836-1648-4BC0-8303-D7B8F725C4F4}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2352244Model of aspartoacylase, a human enzyme involved in brain metabolism.10/29/2020 3:08:25 PM10/29/2020 3:08:25 PMType    Name    Media Type    File Size    Modified 2352_hi_2i3c_S    Low 113 KB 3/29/2019 11:47 AM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13300https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{816D0D7B-ED59-4000-BF2A-0FCB0B539282}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2387251A model of thymidylate synthase complementing protein from <i>Thermotoga maritime</i>.10/29/2020 4:55:29 PM10/29/2020 4:55:29 PMType    Name    Media Type    File Size    Modified 2387_th_tm04491_thumbnail    Thumbnail 64 KB 3/12/2019 11:53 AM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx16500https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{C813EBA4-E90A-4989-BB0C-B98FA669BD0A}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2395254Crystals of fungal lipase protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures.10/29/2020 4:59:29 PM10/29/2020 4:59:29 PMType    Name    Media Type    File Size    Modified f02G_fungal_lipase1_S    Low 35 KB 9/7/2016 3:09 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx11200https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{C8E0FF94-6FAA-4237-A337-7029979B87B4}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2347312Model of the mammalian iron enzyme cysteine dioxygenase from a mouse.10/29/2020 3:01:48 PM10/29/2020 3:01:48 PMType    Name    Media Type    File Size    Modified 2347_hi_2atf_S    Low 101 KB 3/29/2019 11:49 AM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13300https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{747C57A6-D312-4075-B699-1B0268093AF9}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2380316Model of an enzyme, PanB, from <i>Mycobacterium tuberculosis</i>, the bacterium that causes most cases of tuberculosis. This enzyme is an attractive drug target.10/29/2020 4:44:22 PM10/29/2020 4:44:22 PMType    Name    Media Type    File Size    Modified hi_Rv2225_L    Low 53 KB 6/3/2016 3:10 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15500https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{598D1C54-0A52-4388-8B15-9D8F0CAD6996}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2741363Like a strand of white pearls, DNA wraps around an assembly of special proteins called histones (colored) to form the nucleosome, a structure responsible for regulating genes and condensing DNA strands to fit into the cell's nucleus. Researchers once thought that nucleosomes regulated gene activity through their histone tails (dotted lines), but a 2010 study revealed that the structures' core also plays a role. The finding sheds light on how gene expression is regulated and how abnormal gene regulation can lead to cancer. Featured in the May 19, 2010, issue of <a href=http://publications.nigms.nih.gov/biobeat/10-05-19/index.html#1 target="_blank"><em>Biomedical Beat</em></a>.8/18/2020 6:57:42 PM8/18/2020 6:57:42 PMto form the nucleosome, a structure responsible for regulating genes and condensing DNA dotted lines), but a 2010 study revealed that the structures' core also plays a role STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx14000https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{C3ADC02D-DA98-4D44-899B-1EA1E1D08A0A}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6346716Salk researchers captured the structure of a protein complex called an intasome (center) that lets viruses similar to HIV establish permanent infection in their hosts. The intasome hijacks host genomic material, DNA (white) and histones (beige), and irreversibly inserts viral DNA (blue).” The image was created by Jamie Simon and Dmitry Lyumkis. Work that led to the 3D map was published in: Ballandras-Colas A, Brown M, Cook NJ, Dewdney TG, Demeler B, Cherepanov P, Lyumkis D, & Engelman AN. (2016). Cryo-EM reveals a novel octameric integrase structure for ?-retroviral intasome function. Nature, 530(7590), 358—361 12/21/2020 5:05:18 PM12/21/2020 5:05:18 PMCryo-EM reveals a novel octameric integrase structure for ?-retroviral intasome function Salk researchers captured the structure of a protein complex called an intasome (center STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx17600https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{0AE83450-8445-49EC-9EF9-CFA2DA90F559}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6549895Cilia (cilium in singular) are complex molecular machines found on many of our cells. One component of cilia is the doublet microtubule, a major part of cilia’s skeletons that give them support and shape. This animated video illustrates the structure of doublet microtubules, which contain 451 protein chains that were mapped using cryo-electron microscopy. Image can be found here <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6548"> 6548. </a>12/22/2020 3:27:36 PM12/22/2020 3:27:36 PMType    Name    Media Type    File Size    Modified Image can be found here <a The Structure of Cilia’s Doublet Microtubules Molecular Structures STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx12700https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{A1D764DD-877B-4E0D-A205-777FEF569AD9}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3416529X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Found in the journal, Nature, Chemical Biology 8, 366-374 (2012). Series of seven images. Related to <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3413">image 3413</a> , <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3414">image 3414</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3415">image 3415</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3417">image 3417</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3418">image 3418</a> and <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3419">image 3419</a>.12/23/2020 11:08:36 PM12/23/2020 11:08:36 PMX-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 4 We create the original protein structures in pymol which only allows us to write out png STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx12400https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{4AE56C0B-1545-4D0A-997E-59755F61D8EE}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
5780777Ribosomes are complex machines made up of more than 50 proteins and three or four strands of genetic material called ribosomal RNA (rRNA). The busy cellular machines make proteins, which are critical to almost every structure and function in the cell. To do so, they read following protein-building instructions, which come as strands of messenger RNA. Ribosomes are found in all forms of cellular life—people, plants, animals, even bacteria. This illustration of a bacterial ribosome was produced using detailed information about the position of every atom in the complex. Several antibiotic medicines work by disrupting bacterial ribosomes but leaving human ribosomes alone. Scientists are carefully comparing human and bacterial ribosomes to spot differences between the two. Structures that are present only in the bacterial version could serve as targets for new antibiotic medications.12/18/2020 8:00:42 PM12/18/2020 8:00:42 PMStructures that are present only in the bacterial version could serve as targets for new make proteins, which are critical to almost every structure and function in the cell STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx16100https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{AFD33B76-302D-4052-9726-239615EBB6FE}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
5855646Superresolution microscopy work on ER in the peripheral areas of the cell showing details of the structure and arrangement in a complex web of tubes <br></br> The endoplasmic reticulum (ER) is a continuous membrane that extends like a net from the envelope of the nucleus outward to the cell membrane. The ER plays several roles within the cell, such as in protein and lipid synthesis and transport of materials between organelles. The ER has a flexible structure to allow it to accomplish these tasks by changing shape as conditions in the cell change. Shown here an image created by superresolution microscopy of the ER in the peripheral areas of the cell showing details of the structure and the arrangements in a complex web of tubes. Related to images <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=3779">5856</a> and <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=3784">5857</a>.12/18/2020 8:47:02 PM12/18/2020 8:47:02 PMof the cell showing details of the structure and arrangement in a complex web of tubes The ER has a flexible structure to allow it to accomplish these tasks by changing shape as STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx12700https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{0F883DA0-7154-4D41-A93F-1F9B124B47EC}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2401188A crystal of bacterial alpha amylase protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures.8/6/2020 6:41:11 PM8/6/2020 6:41:11 PMType    Name    Media Type    File Size    Modified f06A_bacterial_alpha_amylase1_S    Low 36 KB 9/7/2016 3:25 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx11900https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{D45D3817-6405-4ED0-A909-829536C06DD2}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2392253A crystal of sheep hemoglobin protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures.10/29/2020 4:58:13 PM10/29/2020 4:58:13 PMType    Name    Media Type    File Size    Modified f02A_sheep_hemoglobin_S    Low 50 KB 9/7/2016 3:07 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx11400https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{1FAC4EF0-38F5-4FC0-9A20-47A56101DC30}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2350314Model of the mandelate racemase enzyme from <i>Bacillus subtilis</i>, a bacterium commonly found in soil.10/29/2020 3:05:19 PM10/29/2020 3:05:19 PMType    Name    Media Type    File Size    Modified 2350_th_2gge1_M    Medium 108 KB 3/12/2019 11:43 AM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx14900https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{A5644D52-4C8F-4D34-8EB7-712DB5A0B321}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2379315Model of a major secreted protein of unknown function, which is only found in mycobacteria, the class of bacteria that causes tuberculosis. Based on structural similarity, this protein may be involved in host-bacterial interactions.10/29/2020 4:43:06 PM10/29/2020 4:43:06 PMType    Name    Media Type    File Size    Modified 2379_hi_Rv1926c_S    Low 94 KB 3/29/2019 11:32 AM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx14100https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{2DCFCAE8-6EC7-4904-BAA1-CAE58B970677}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131