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Resources
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Laboratory Safety and Guidelines
Training Resources
NIGMS Training Twitter Feed
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Science Education Partnership Awards (SEPA)
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Related Information
DRCB News
DRCB Staff Contacts
Resources
NIH RePORTER
Grants and Funding
Funding Opportunities
Current NIGMS Funding Opportunities
Parent Announcements for Investigator-Initiated Applications
Research Funding
Research Project Grants (NIH Parent R01)
Maximizing Investigators' Research Awards (MIRA)
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Small Business Research
Multidisciplinary Teams/Collaborative Research
Technology Development
Research Resources
Clinical Studies and Trials
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Administrative Supplements
All Funding Opportunities
Grant Application and Post-Award Information
How to Apply
Grant Application and Review Process
NIGMS Funding Policies
Post-Award Information
Resources
Attribution of NIH/NIGMS Support
Message to NIGMS Investigators
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2363
20096
The goal of the PSI is to determine the three-dimensional shapes of a wide range of proteins by solving the structures of representative members of each protein family found in nature. The collection of structures should serve as a valuable resource for biomedical research scientists.
10/29/2020 4:12:18 PM
10/29/2020 4:12:18 PM
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The collection of
structures
should serve as a valuable resource for biomedical research
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32
2342
20007
X-ray structure of a new DNA repair enzyme superfamily representative from the human gastrointestinal bacterium <i>Enterococcus faecalis</i>. European scientists used this structure to generate homologous structures. Featured as the May 2007 Protein Structure Initiative Structure of the Month.
10/29/2020 2:46:36 PM
10/29/2020 2:46:36 PM
European scientists used this
structure
to generate homologous
structures
Featured as the May 2007 Protein
Structure
Initiative
Structure
of the Month
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32
32
2365
20098
A global "map of the protein structure universe." The Berkeley Structural Genomics Center has developed a method to visualize the vast universe of protein structures in which proteins of similar structure are located close together and those of different structures far away in the space. This map, constructed using about 500 of the most common protein folds, reveals a highly non-uniform distribution, and shows segregation between four elongated regions corresponding to four different protein classes (shown in four different colors). Such a representation reveals a high-level of organization of the protein structure universe.
10/29/2020 4:16:23 PM
10/29/2020 4:16:23 PM
a representation reveals a high-level of organization of the protein
structure
universe
Map of protein
structures
01
Molecular
Structures
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32
2343
20072
This crystal structure shows a conserved hypothetical protein from <i>Mycobacterium tuberculosis</i>. Only 12 other proteins share its sequence homology, and none has a known function. This structure indicates the protein may play a role in metabolic pathways. Featured as one of the August 2007 Protein Structure Initiative Structures of the Month.
10/29/2020 2:48:36 PM
10/29/2020 2:48:36 PM
This
structure
indicates the protein may play a role in metabolic pathways
Featured as one of the August 2007 Protein
Structure
Initiative
Structures
of the Month
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32
32
2508
19458
Proteins are made of amino acids hooked end-to-end like beads on a necklace. To become active, proteins must twist and fold into their final, or "native," conformation." A protein's final shape enables it to accomplish its function. Featured in <a href=http://publications.nigms.nih.gov/structlife/ target="_blank"><i>The Structures of Life</i></a>.
9/18/2020 6:06:49 PM
9/18/2020 6:06:49 PM
/education/Booklets/The-Structures-of-Life/Pages/Home.aspx"><em>The
Structures
of Life</em
The
Structures
of Life page 3
Molecular
Structures
structure
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32
32
2337
19501
Crystal structure of the beta2-adrenergic receptor protein. This is the first known structure of a human G protein-coupled receptor, a large family of proteins that control critical bodily functions and the action of about half of today's pharmaceuticals. Featured as one of the November 2007 Protein Structure Initiative Structures of the Month.
10/29/2020 2:35:50 PM
10/29/2020 2:35:50 PM
Type Name Media Type File Size Modified
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Molecular
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32
2340
19504
This is the first structure of a protein derived from the metagenomic sequences collected during the Sorcerer II Global Ocean Sampling project. The crystal structure shows a barrel protein with a ferredoxin-like fold and a long chain fatty acid in a deep cleft (shaded red). Featured as one of the August 2007 Protein Structure Initiative Structures of the Month.
10/29/2020 2:41:27 PM
10/29/2020 2:41:27 PM
Type Name Media Type File Size Modified
2340_jcsg20d6_S Low 79 KB 3/29/2019 1:45 PM Constantinides, Stephen (NIH/NIGMS) [C
Molecular
Structures
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32
2367
20099
A global "map of the protein structure universe" indicating the positions of specific proteins. The preponderance of small, less-structured proteins near the origin, with the more highly structured, large proteins towards the ends of the axes, may suggest the evolution of protein structures.
10/29/2020 4:18:37 PM
10/29/2020 4:18:37 PM
Type Name Media Type File Size Modified
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32
32
2748
19856
This ribbon drawing of a protein hand drawn and colored by researcher Jane Richardson in 1981 helped originate the ribbon representation of proteins that is now ubiquitous in molecular graphics. The drawing shows the 3-dimensional structure of the protein triose phosphate isomerase. The green arrows represent the barrel of eight beta strands in this structure and the brown spirals show the protein's eight alpha helices. A black and white version of this drawing originally illustrated a <a href=http://kinemage.biochem.duke.edu/teaching/anatax target="_blank">review article</a> in <i>Advances in Protein Chemistry</i>, volume 34, titled "Anatomy and Taxonomy of Protein Structures." The illustration was selected as Picture of The Day on the English Wikipedia for November 19, 2009. Other important and beautiful images of protein structures by Jane Richardson are available in her <a href=http://commons.wikimedia.org/wiki/User:Dcrjsr/gallery_of_protein_structure target="_blank">Wikimedia gallery</a>.
8/18/2020 7:55:11 PM
8/18/2020 7:55:11 PM
The drawing shows the 3-dimensional
structure
of the protein triose phosphate isomerase
barrel of eight beta strands in this
structure
and the brown spirals show the protein's
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32
32
2373
19547
Crystal structure of oligoendopeptidase F, a protein slicing enzyme from <i>Bacillus stearothermophilus</i>, a bacterium that can cause food products to spoil. The crystal was formed using a microfluidic capillary, a device that enables scientists to independently control the parameters for protein crystal nucleation and growth. Featured as one of the July 2007 Protein Structure Initiative Structures of the Month.
10/29/2020 4:30:39 PM
10/29/2020 4:30:39 PM
Type Name Media Type File Size Modified
Technologies Center for Gene to 3D
Structure
/Midwest Center for Structural Genomics
Molecular
Structures
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32
32
2345
20073
Structure of a magnesium transporter protein from an antibiotic-resistant bacterium (<i>Enterococcus faecalis</i>) found in the human gut. Featured as one of the June 2007 Protein Sructure Initiative Structures of the Month.
10/29/2020 2:58:36 PM
10/29/2020 2:58:36 PM
Type Name Media Type File Size Modified
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Molecular
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32
32
3438
19424
The chemical structure of the morphine molecule
8/22/2020 4:44:39 PM
8/22/2020 4:44:39 PM
Morphine_
structure
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32
32
2395
19641
Crystals of fungal lipase protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures.
10/29/2020 4:59:29 PM
10/29/2020 4:59:29 PM
Type Name Media Type File Size Modified
f02G_fungal_lipase1_S Low 35 KB 9/7/2016 3:09 PM Varkala, Venkat (NIH/NIGMS) [C
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32
32
2339
19503
NMR solution structure of a plant protein that may function in host defense. This protein was expressed in a convenient and efficient wheat germ cell-free system. Featured as the June 2007 Protein Structure Initiative Structure of the Month.
10/29/2020 2:40:04 PM
10/29/2020 2:40:04 PM
Type Name Media Type File Size Modified
Featured as the June 2007 Protein
Structure
Initiative
Structure
of the Month
Molecular
Structures
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32
32
2392
19640
A crystal of sheep hemoglobin protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures.
10/29/2020 4:58:13 PM
10/29/2020 4:58:13 PM
Type Name Media Type File Size Modified
f02A_sheep_hemoglobin_S Low 50 KB 9/7/2016 3:07 PM Varkala, Venkat (NIH/NIGMS) [C
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32
32
2372
19546
Crystal structure of a protein with unknown function from <i>Xanthomonas campestris</i>, a plant pathogen. Eight copies of the protein crystallized to form a ring. Chosen as the December 2007 Protein Structure Initiative Structure of the Month.
10/29/2020 4:26:44 PM
10/29/2020 4:26:44 PM
Type Name Media Type File Size Modified
Chosen as the December 2007 Protein
Structure
Initiative
Structure
of the Month
Molecular
Structures
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32
32
3307
20104
A study published in March 2012 used cryo-electron microscopy to determine the structure of the DNA replication origin recognition complex (ORC), a semi-circular, protein complex (yellow) that recognizes and binds DNA to start the replication process. The ORC appears to wrap around and bend approximately 70 base pairs of double stranded DNA (red and blue). Also shown is the protein Cdc6 (green), which is also involved in the initiation of DNA replication. The video shows the structure from different angles. From a Brookhaven National Laboratory <a href=http://www.bnl.gov/bnlweb/pubaf/pr/PR_display.asp?prID=1391&template=Today target="_blank">news release</a>, "Study Reveals How Protein Machinery Binds and Wraps DNA to Start Replication." See related image <a href=http://images.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3597><i>3597</i></a>.
12/22/2020 11:01:10 PM
12/22/2020 11:01:10 PM
The light brown shading represents the
structure
obtained by cryo-EM
The ribbon diagram
structures
came from X-ray crystallography and were superimposed on the cryo-EM
structure
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32
32
2782
19949
This is a magnified view of an <i>Arabidopsis thaliana</i> leaf after several days of infection with the pathogen <i>Hyaloperonospora arabidopsidis</i>. The pathogen's blue hyphae grow throughout the leaf. On the leaf's edges, stalk-like structures called sporangiophores are beginning to mature and will release the pathogen's spores. Inside the leaf, the large, deep blue spots are structures called oopsorangia, also full of spores. Compare this response to that shown in Image 2781. Jeff Dangl has been funded by NIGMS to study the interactions between pathogens and hosts that allow or suppress infection.
8/28/2020 7:07:55 PM
8/28/2020 7:07:55 PM
Type Name Media Type File Size Modified
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32
32
5780
20092
Ribosomes are complex machines made up of more than 50 proteins and three or four strands of genetic material called ribosomal RNA (rRNA). The busy cellular machines make proteins, which are critical to almost every structure and function in the cell. To do so, they read following protein-building instructions, which come as strands of messenger RNA. Ribosomes are found in all forms of cellular life—people, plants, animals, even bacteria. This illustration of a bacterial ribosome was produced using detailed information about the position of every atom in the complex. Several antibiotic medicines work by disrupting bacterial ribosomes but leaving human ribosomes alone. Scientists are carefully comparing human and bacterial ribosomes to spot differences between the two. Structures that are present only in the bacterial version could serve as targets for new antibiotic medications.
12/18/2020 8:00:42 PM
12/18/2020 8:00:42 PM
Structures
that are present only in the bacterial version could serve as targets for new
make proteins, which are critical to almost every
structure
and function in the cell
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32
32
2351
20078
An NMR solution structure model of the transfer RNA splicing enzyme endonuclease in humans (subunit Sen15). This represents the first structure of a eukaryotic tRNA splicing endonuclease subunit.
10/29/2020 3:06:53 PM
10/29/2020 3:06:53 PM
Type Name Media Type File Size Modified
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32
32
3660
20173
Ribbon diagram showing the structure of Ribonuclease P with tRNA.
2/4/2020 8:55:06 PM
2/4/2020 8:55:06 PM
Type Name Media Type File Size Modified
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2513
19463
HIV is a retrovirus, a type of virus that carries its genetic material not as DNA but as RNA. Long before anyone had heard of HIV, researchers in labs all over the world studied retroviruses, tracing out their life cycle and identifying the key proteins the viruses use to infect cells. When HIV was identified as a retrovirus, these studies gave AIDS researchers an immediate jump-start. The previously identified viral proteins became initial drug targets. See images <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2514">2514</a> and <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2515">2515</a> for labeled versions of this illustration. Featured in <a href=http://publications.nigms.nih.gov/structlife/ target="_blank"><i>The Structures of Life</i></a>.
9/25/2020 4:26:31 PM
9/25/2020 4:26:31 PM
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The
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A 3D reconstruction of a transient receptor potential channel called TRPV5 that was created based on cryo-electron microscopy images. TRPV5 is primarily found in kidney cells and is essential for reabsorbing calcium into the blood.
8/10/2020 11:36:21 PM
8/10/2020 11:36:21 PM
Currently, her laboratory is using cryo-EM to determine TRPV5 channel
structures
in conditions that better mimic those found in the body, including the presence
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Model of the enzyme Nicotinic acid phosphoribosyltransferase. This enzyme, from the archaebacterium, <i>Pyrococcus furiosus</i>, is expected to be structurally similar to a clinically important human protein called B-cell colony enhancing factor based on amino acid sequence similarities and structure prediction methods. The structure consists of identical protein subunits, each shown in a different color, arranged in a ring.
10/29/2020 3:44:23 PM
10/29/2020 3:44:23 PM
factor based on amino acid sequence similarities and
structure
prediction methods
The
structure
consists of identical protein subunits, each shown in a different color
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Kinases are enzymes that add phosphate groups (red-yellow structures) to proteins (green), assigning the proteins a code. In this reaction, an intermediate molecule called ATP (adenosine triphosphate) donates a phosphate group from itself, becoming ADP (adenosine diphosphate). Featured in <a href=http://publications.nigms.nih.gov/medbydesign/ target="_blank"><i>Medicines By Design</i></a>.
3/4/2022 7:55:38 PM
3/4/2022 7:55:38 PM
Type Name Media Type File Size Modified
Kinases are enzymes that add phosphate groups (red-yellow
structures
) to proteins (green), assigning the proteins a
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20127
Researchers have created artificial cilia that wave like the real thing. Zvonimir Dogic and his Brandeis University colleagues combined just a few cilia proteins to create cilia that are able to wave and sweep material around--although more slowly and simply than real ones. The researchers are using the lab-made cilia to study how the structures coordinate their movements and what happens when they don't move properly. Featured in the August 18, 2011, issue of <a href=http://publications.nigms.nih.gov/biobeat/11-08-18/#1 target="_blank"><em>Biomedical Beat</em></a>.
12/23/2020 5:39:06 PM
12/23/2020 5:39:06 PM
Type Name Media Type File Size Modified
the lab-made cilia to study how the
structures
coordinate their movements and what happens
Molecular
Structures
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Model of a human protein associated with the adenylyl cyclase, an enzyme involved in intracellular signaling.
10/29/2020 3:00:19 PM
10/29/2020 3:00:19 PM
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20191
Like a strand of white pearls, DNA wraps around an assembly of special proteins called histones (colored) to form the nucleosome, a structure responsible for regulating genes and condensing DNA strands to fit into the cell's nucleus. Researchers once thought that nucleosomes regulated gene activity through their histone tails (dotted lines), but a 2010 study revealed that the structures' core also plays a role. The finding sheds light on how gene expression is regulated and how abnormal gene regulation can lead to cancer. Featured in the May 19, 2010, issue of <a href=http://publications.nigms.nih.gov/biobeat/10-05-19/index.html#1 target="_blank"><em>Biomedical Beat</em></a>.
8/18/2020 6:57:42 PM
8/18/2020 6:57:42 PM
to form the nucleosome, a
structure
responsible for regulating genes and condensing DNA
dotted lines), but a 2010 study revealed that the
structures
' core also plays a role
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Cryo-electron microscopy (cryo-EM) has the power to capture details of proteins and other small biological structures at the molecular level. This image shows proteins in the capsid, or outer cover, of bacteriophage P22, a virus that infects the Salmonella bacteria. Each color shows the structure and position of an individual protein in the capsid. Thousands of cryo-EM scans capture the structure and shape of all the individual proteins in the capsid and their position relative to other proteins. A computer model combines these scans into the 3-dimension image shown here. Related to image <a href="/Pages/DetailPage.aspx?imageID2=5875">5875</a>.
12/18/2020 9:09:51 PM
12/18/2020 9:09:51 PM
Each color shows the
structure
and position of an individual protein in the capsid
Thousands of cryo-EM scans capture the
structure
and shape of all the individual proteins
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19464
HIV is a retrovirus, a type of virus that carries its genetic material not as DNA but as RNA. Long before anyone had heard of HIV, researchers in labs all over the world studied retroviruses, tracing out their life cycle and identifying the key proteins the viruses use to infect cells. When HIV was identified as a retrovirus, these studies gave AIDS researchers an immediate jump-start. The previously identified viral proteins became initial drug targets. See images <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2513">2513</a> and <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2515">2515</a> for other versions of this illustration. Featured in <a href=http://publications.nigms.nih.gov/structlife/ target="_blank"><i>The Structures of Life</i></a>.
9/25/2020 4:29:40 PM
9/25/2020 4:29:40 PM
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/education/Booklets/The-Structures-of-Life/Pages/Home.aspx"><em>The
Structures
of Life</em
The
Structures
of Life pages 36-37 Life
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2515
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HIV is a retrovirus, a type of virus that carries its genetic material not as DNA but as RNA. Long before anyone had heard of HIV, researchers in labs all over the world studied retroviruses, tracing out their life cycle and identifying the key proteins the viruses use to infect cells. When HIV was identified as a retrovirus, these studies gave AIDS researchers an immediate jump-start. The previously identified viral proteins became initial drug targets. See images <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2513">2513</a> and <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2514">2514</a> for other versions of this illustration. Featured in <a href=http://publications.nigms.nih.gov/structlife/ target="_blank"><i>The Structures of Life</i></a>.
9/25/2020 4:31:12 PM
9/25/2020 4:31:12 PM
Type Name Media Type File Size Modified
HIV is a retrovirus, a type of virus that carries its genetic material not as DNA
The
Structures
of Life pages 36-37
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19812
A special "messy" region of a potassium ion channel is important in its function.
9/8/2020 10:55:58 PM
9/8/2020 10:55:58 PM
BK_Virtual_
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BK_Virtual_
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19915
Kinases are enzymes that add phosphate groups (red-yellow structures) to proteins (green), assigning the proteins a code. In this reaction, an intermediate molecule called ATP (adenosine triphosphate) donates a phosphate group from itself, becoming ADP (adenosine diphosphate). Featured in <a href=http://publications.nigms.nih.gov/medbydesign/ target="_blank"><i>Medicines By Design</i></a>.
3/4/2022 7:54:39 PM
3/4/2022 7:54:39 PM
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32
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19502
Model of a member from the Tex protein family, which is implicated in transcriptional regulation and highly conserved in eukaryotes and prokaryotes. The structure shows significant homology to a human transcription elongation factor that may regulate multiple steps in mRNA synthesis.
10/29/2020 2:37:40 PM
10/29/2020 2:37:40 PM
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32
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2341
19505
Model of the enzyme aminopeptidase N from the human pathogen <i>Neisseria meningitidis</i>, which can cause meningitis epidemics. The structure provides insight on the active site of this important molecule.
10/29/2020 2:43:00 PM
10/29/2020 2:43:00 PM
Type Name Media Type File Size Modified
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32
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19522
Model of aspartoacylase, a human enzyme involved in brain metabolism.
10/29/2020 3:08:25 PM
10/29/2020 3:08:25 PM
Type Name Media Type File Size Modified
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32
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19558
Molecular model of the struture of heme. Heme is a small, flat molecule with an iron ion (dark red) at its center. Heme is an essential component of hemoglobin, the protein in blood that carries oxygen throughout our bodies. This image first appeared in the <a href="http://publications.nigms.nih.gov/findings/sept13/hooked-on-heme.asp">September 2013 issue of Findings Magazine</a>.
9/27/2020 4:35:34 AM
9/27/2020 4:35:34 AM
Type Name Media Type File Size Modified
Structure
of heme, top view
Hi Sharon, The two heme
structures
can be made public
Molecular
Structures
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Molecular model of the struture of heme. Heme is a small, flat molecule with an iron ion (dark red) at its center. Heme is an essential component of hemoglobin, the protein in blood that carries oxygen throughout our bodies. This image first appeared in the <a href="http://publications.nigms.nih.gov/findings/sept13/hooked-on-heme.asp">September 2013 issue of Findings Magazine</a>.
9/27/2020 4:37:18 AM
9/27/2020 4:37:18 AM
Type Name Media Type File Size Modified
Structure
of heme, side view
Hi Sharon, The two heme
structures
can be made public
Molecular
Structures
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32
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2378
19552
Model of a protein, antigen 85B, that is the most abundant protein exported by <i>Mycobacterium tuberculosis</i>, which causes most cases of tuberculosis. Antigen 85B is involved in building the bacterial cell wall and is an attractive drug target. Based on its structure, scientists have suggested a new class of antituberculous drugs.
10/29/2020 4:41:39 PM
10/29/2020 4:41:39 PM
Type Name Media Type File Size Modified
Molecular
Structures
drug development, model, protein
structure
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20125
Structure of sortase b from the bacterium <i>B. anthracis</i>, which causes anthrax. Sortase b is an enzyme used to rob red blood cells of iron, which the bacteria need to survive.
10/29/2020 4:53:35 PM
10/29/2020 4:53:35 PM
Type Name Media Type File Size Modified
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32
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3327
20109
This 1 1/2-minute video animation was produced for chemical biologist Stuart Schreiber's lab page. Link to video: http://www.broadinstitute.org/chembio/lab_schreiber/anims/animations/smdbFold.php. The animation shows how diverse chemical structures can be produced in the lab.
12/23/2020 5:04:14 PM
12/23/2020 5:04:14 PM
Type Name Media Type File Size Modified
PERMISSION: From: Eric Keller [mailto:bloopatone@gmail.com] Sent: Friday, March 30, 2012 11:55 PM To: Machalek, Alisa Zapp (NIH/NIGMS) [E] Subject: Re: seeking
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32
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2347
20075
Model of the mammalian iron enzyme cysteine dioxygenase from a mouse.
10/29/2020 3:01:48 PM
10/29/2020 3:01:48 PM
Type Name Media Type File Size Modified
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32
32
2350
20077
Model of the mandelate racemase enzyme from <i>Bacillus subtilis</i>, a bacterium commonly found in soil.
10/29/2020 3:05:19 PM
10/29/2020 3:05:19 PM
Type Name Media Type File Size Modified
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32
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20119
Model of an enzyme, PanB, from <i>Mycobacterium tuberculosis</i>, the bacterium that causes most cases of tuberculosis. This enzyme is an attractive drug target.
10/29/2020 4:44:22 PM
10/29/2020 4:44:22 PM
Type Name Media Type File Size Modified
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32
32
2387
20126
A model of thymidylate synthase complementing protein from <i>Thermotoga maritime</i>.
10/29/2020 4:55:29 PM
10/29/2020 4:55:29 PM
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32
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19639
Solution NMR structure of protein target WR41 (left) from <i>C. elegans</i>. Noting the unanticipated structural similarity to the ubiquitin protein (Ub) found in all eukaryotic cells, researchers discovered that WR41 is a Ub-like modifier, ubiquitin-fold modifier 1 (Ufm1), on a newly uncovered ubiquitin-like pathway. Subsequently, the PSI group also determined the three-dimensional structure of protein target HR41 (right) from humans, the E2 ligase for Ufm1, using both NMR and X-ray crystallography.
10/29/2020 4:56:46 PM
10/29/2020 4:56:46 PM
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6601
19881
This animation shows atoms of the HIV capsid, the shell that encloses the virus's genetic material. Scientists determined the exact structure of the capsid using a variety of imaging techniques and analyses. They then entered this data into a supercomputer to produce this image. Learn more in the <a href="https://www.nigms.nih.gov/education/pages/Factsheet_StructuralBiology.aspx"> structural biology fact sheet</a>. Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=3477">3477</a>.
1/28/2021 8:06:44 PM
1/28/2021 8:06:44 PM
Atomic-Level
Structure
of the HIV Capsid High 20229 KB 12/10/2020 5:41 PM
atomic-level
structure
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32
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2385
20124
Model based on X-ray crystallography of the structure of a small heat shock protein complex from the bacteria, <i>Methanococcus jannaschii</i>. <i>Methanococcus jannaschii</i> is an organism that lives at near boiling temperature, and this protein complex helps it cope with the stress of high temperature. Similar complexes are produced in human cells when they are "stressed" by events such as burns, heart attacks, or strokes. The complexes help cells recover from the stressful event.
10/29/2020 4:52:21 PM
10/29/2020 4:52:21 PM
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Molecular
Structures
protein
structure
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A crystal of bacterial alpha amylase protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures.
8/6/2020 6:41:11 PM
8/6/2020 6:41:11 PM
Type Name Media Type File Size Modified
f06A_bacterial_alpha_amylase1_S Low 36 KB 9/7/2016 3:25 PM Varkala, Venkat (NIH/NIGMS) [C
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Model of a major secreted protein of unknown function, which is only found in mycobacteria, the class of bacteria that causes tuberculosis. Based on structural similarity, this protein may be involved in host-bacterial interactions.
10/29/2020 4:43:06 PM
10/29/2020 4:43:06 PM
Type Name Media Type File Size Modified
2379_hi_Rv1926c_S Low 94 KB 3/29/2019 11:32 AM Constantinides, Stephen (NIH/NIGMS) [C
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