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2456134Lab-made liposomes contract where Z rings have gathered together and the constriction forces are greatest (arrows). The top picture shows a liposome, and the bottom picture shows fluorescence from Z rings (arrows) inside the same liposome simultaneously.8/20/2020 5:58:21 PM8/20/2020 5:58:21 PMType    Name    Media Type    File Size    Modified Bactdiv_M    Medium 16 KB 6/3/2016 3:11 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx180130https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{164D7686-BE0D-459F-9F57-1E2ED31BA325}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6803966Groups of <em>Staphylococcus aureus</em> bacteria (blue) attached to a microstructured titanium surface (green) that mimics an orthopedic implant used in joint replacement. The attachment of pre-formed groups of bacteria may lead to infections because the groups can tolerate antibiotics and evade the immune system. This image was captured using a scanning electron microscope. <Br><Br>More information on the research that produced this image can be found in the <em>Antibiotics</em> paper<a href="https://www.mdpi.com/2079-6382/10/8/889"> "Free-floating aggregate and single-cell-initiated biofilms of <em>Staphylococcus aureus</em>" </a>by Gupta et al. <Br><Br> Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6804">6804</a> and video <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6805">6805</a>. 10/18/2023 2:58:27 PM10/18/2023 2:58:27 PMType    Name    Media Type    File Size    Modified SF Aggregates on patterned surfaces-blue_green_M    Medium 65 KB 1/20/2022 1:49 PM Crowley, Rachel (NIH STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx258110https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{E37D8CD5-D785-4772-AC02-AD968EA3AABF}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
1292296The endoplasmic reticulum comes in two types: Rough ER is covered with ribosomes and prepares newly made proteins; smooth ER specializes in making lipids and breaking down toxic molecules. Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.10/28/2020 7:28:49 PM10/28/2020 7:28:49 PMType    Name    Media Type    File Size    Modified ITC_SER_inset_Copy_S    Low 26 KB 8/10/2016 3:50 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx460170https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{14BB84F1-5BDA-4E80-9C7C-799788D69094}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3491596A protein called kinesin (blue) is in charge of moving cargo around inside cells and helping them divide. It's powered by biological fuel called ATP (bright yellow) as it scoots along tube-like cellular tracks called microtubules (gray).9/8/2020 11:21:32 PM9/8/2020 11:21:32 PMType    Name    Media Type    File Size    Modified cool_image_kinesin_L    Low 7 KB 6/3/2016 3:30 PM aamishral2 (NIH/NIGMS) [C Would you allow us to do so, and would you please let us know how you would like to STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx18050https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{35B500A0-F314-4453-AED7-2C9A600F10D9}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
1272160The three fibers of the cytoskeleton--microtubules in blue, intermediate filaments in red, and actin in green--play countless roles in the cell. Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.10/28/2020 4:14:44 PM10/28/2020 4:14:44 PMType    Name    Media Type    File Size    Modified ITC_Cytoskeleton_S    Low 144 KB 8/24/2016 3:18 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx19150https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{E37185A4-4561-456C-AC76-3A1F352FA533}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
1092287A whole yeast (<i>Saccharomyces cerevisiae</i>) cell viewed by X-ray microscopy. Inside, the nucleus and a large vacuole (red) are visible.8/27/2020 9:02:59 PM8/27/2020 9:02:59 PMType    Name    Media Type    File Size    Modified Larabell_yeast1.thumb    Thumbnail 5 KB 6/3/2016 2:45 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx16160https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{235B7768-263F-4DC4-A8FB-DA3A0F629CAD}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2307299The fledgling field of X-ray microscopy lets researchers look inside whole cells rapidly frozen to capture their actions at that very moment. Here, a yeast cell buds before dividing into two. Colors show different parts of the cell. Seeing whole cells frozen in time will help scientists observe cells' complex structures and follow how molecules move inside them. Featured in the June 21, 2005, issue of <a href=http://publications.nigms.nih.gov/biobeat/05-06-21/#1 target="_blank"><em>Biomedical Beat</em></a>.10/29/2020 12:52:06 PM10/29/2020 12:52:06 PMType    Name    Media Type    File Size    Modified cells_frozen_in_time_L    Low 4 KB 6/3/2016 3:08 PM aamishral2 (NIH/NIGMS) [C Here, a yeast cell buds before STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx14950https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{71D94C18-4C1B-4E16-B859-AACCFD847EC4}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6899883High-resolution time lapse of epithelial (skin) cell migration and wound healing. It shows an image taken every 13 seconds over the course of almost 14 minutes. The images were captured with quantitative orientation-independent differential interference contrast (DIC) microscope (left) and a conventional DIC microscope (right). <Br><Br>More information about the research that produced this video can be found in the <em>Journal of Microscopy</em> paper <a href="https://onlinelibrary.wiley.com/doi/10.1111/jmi.12682/">“An Orientation-Independent DIC Microscope Allows High Resolution Imaging of Epithelial Cell Migration and Wound Healing in a Cnidarian Model”</a> by Malamy and Shribak. 6/30/2022 4:45:48 PM6/30/2022 4:45:48 PMType    Name    Media Type    File Size    Modified circularlamellipodia    High 17708 KB 6/30/2022 3:03 PM Crowley, Rachel (NIH/NIGMS) [E STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15350https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{497BC427-08F6-402E-B25B-3FF48F096460}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6593901Cell-like compartments that spontaneously emerged from scrambled frog eggs, with nuclei (blue) from frog sperm. Endoplasmic reticulum (red) and microtubules (green) are also visible. Image created using confocal microscopy. <br> <p>For more photos of cell-like compartments from frog eggs view: <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6584">6584</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6585">6585</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6586">6586</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6591">6591</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6592">6592</a>.</p> <p>For videos of cell-like compartments from frog eggs view:&nbsp;<a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6587">6587</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6588">6588</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6589">6589</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6590">6590</a>.</p>9/13/2020 3:39:51 PM9/13/2020 3:39:51 PMType    Name    Media Type    File Size    Modified img6_cheng_confocal_nuc_t76_M    Medium 62 KB 9/15/2020 10:04 AM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx17050https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{552FC5C2-8EFE-4A87-9B6E-FE57AED81528}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2457135Novel biosensor system maps the timing and location of Rac protein activation in a living mouse embryo fibroblast.8/20/2020 6:22:04 PM8/20/2020 6:22:04 PMType    Name    Media Type    File Size    Modified RAC1_activation_in_motile_fibroblast    High 627 KB 6/28/2016 3:00 PM Hall, Monique (NIH/NCI) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx16260https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{B0808E7F-84F4-4D3E-A355-D7F70A509103}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6982932Fourteen neurons (magenta) in the adult <em> Drosophila </em> brain produce insulin, and fat tissue sends packets of lipids to the brain via the lipoprotein carriers (green). This image was captured using a confocal microscope and shows a maximum intensity projection of many slices. <Br><Br>Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6983">6983</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6984">6984</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6985">6985</a>.12/19/2023 7:12:13 PM12/19/2023 7:12:13 PMType    Name    Media Type    File Size    Modified #1_Dilp ApoII_M    Medium 320 KB 12/19/2023 2:13 PM Crowley, Rachel (NIH/NIGMS) [E Please let me know if you STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx355160https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{6519601A-B4F6-4AFB-89E6-4BA77ECF4F0A}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2418323This delicate, birdlike projection is an immature seed of the <i>Arabidopsis</i> plant. The part in blue shows the cell that gives rise to the endosperm, the tissue that nourishes the embryo. The cell is expressing only the maternal copy of a gene called MEDEA. This phenomenon, in which the activity of a gene can depend on the parent that contributed it, is called genetic imprinting. In <i>Arabidopsis</i>, the maternal copy of MEDEA makes a protein that keeps the paternal copy silent and reduces the size of the endosperm. In flowering plants and mammals, this sort of genetic imprinting is thought to be a way for the mother to protect herself by limiting the resources she gives to any one embryo. Featured in the May 16, 2006, issue of <a href=http://publications.nigms.nih.gov/biobeat/06-05-16/#1 target="_blank"><em>Biomedical Beat</em></a>.8/17/2020 7:59:57 PM8/17/2020 7:59:57 PMType    Name    Media Type    File Size    Modified Genetic_imprinting_L    Low 156 KB 6/3/2016 3:10 PM aamishral2 (NIH/NIGMS) [C In flowering plants and mammals, this sort of genetic imprinting is thought to be a way for the STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx163130https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{755171FE-A0AC-4D55-8F76-BC6554F6076A}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
68001015A Janus particle being used to activate a T cell, a type of immune cell. A Janus particle is a specialized microparticle with different physical properties on its surface, and this one is coated with nickel on one hemisphere and anti-CD3 antibodies (light blue) on the other. The nickel enables the Janus particle to be moved using a magnet, and the antibodies bind to the T cell and activate it. The T cell in this video was loaded with calcium-sensitive dye to visualize calcium influx, which indicates activation. The intensity of calcium influx was color coded so that warmer color indicates higher intensity. Being able to control Janus particles with simple magnets is a step toward controlling individual cells’ activities without complex magnetic devices.<Br><Br> More details can be found in the <em> Angewandte Chemie </em> paper <a href="https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201601211">“Remote control of T cell activation using magnetic Janus particles”</a> by Lee et al. This video was captured using epi-fluorescence microscopy. <Br><Br>Related to video <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6801">6801</a>. 8/17/2023 5:23:21 PM8/17/2023 5:23:21 PMType    Name    Media Type    File Size    Modified Magnetic particle switch for T cell activation-H    High 25441 KB 1/21/2022 2:46 PM Dolan, Lauren (NIH/NIGMS STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15860https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{21EB1F1F-CCAE-4507-991B-8813F29A78C3}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3547667An image of the area of the mouse brain that serves as the 'master clock,' which houses the brain's time-keeping neurons. The nuclei of the clock cells are shown in blue. A small molecule called VIP, shown in green, enables neurons in the central clock in the mammalian brain to synchronize. More information about the research behind this image can be found in a <a href="http://biobeat.nigms.nih.gov/">Biomedical Beat Blog</a> posting from November 2013.5/13/2022 12:40:18 PM5/13/2022 12:40:18 PMType    Name    Media Type    File Size    Modified VIP_protein_color_L    Low 49 KB 6/3/2016 3:31 PM aamishral2 (NIH/NIGMS) [C An image of the area of the mouse STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx14180https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{A9C06EAD-A1B6-4BCB-A865-C886100DF8C1}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2759497In the absence of the engulfment receptor Draper, salivary gland cells (light blue) persist in the thorax of a developing <i>Drosophila melanogaster</i> pupa. See image 2758 for a cross section of a normal pupa that does express Draper.8/21/2020 7:28:19 PM8/21/2020 7:28:19 PMType    Name    Media Type    File Size    Modified draper-mutant_S    Low 16 KB 9/14/2016 11:24 AM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15970https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{4A178706-B83E-481F-B939-8ACA0AB2C112}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
5843644This video results from a research project to visualize which regions of the adult fruit fly (Drosophila) brain derive from each neural stem cell. First, researchers collected several thousand fruit fly larvae and fluorescently stained a random stem cell in the brain of each. The idea was to create a population of larvae in which each of the 100 or so neural stem cells was labeled at least once. When the larvae grew to adults, the researchers examined the flies’ brains using confocal microscopy. With this technique, the part of a fly’s brain that derived from a single, labeled stem cell “lights up.” The scientists photographed each brain and digitally colorized its lit-up area. By combining thousands of such photos, they created a 3-dimensional, color-coded map that shows which part of the Drosophila brain comes from each of its ~100 neural stem cells. In other words, each colored region shows which neurons are the progeny or “clones” of a single stem cell. This work established a hierarchical structure as well as nomenclature for the neurons in the Drosophila brain. Further research will relate functions to structures of the brain. Related to images <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=3745">5838</a> and <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=3808">5868</a 5/13/2022 12:38:16 PM5/13/2022 12:38:16 PMType    Name    Media Type    File Size    Modified 5843_Video 4_S    Low 110 KB 3/28/2019 2:29 PM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx19970https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{AA857D78-0446-4218-B128-C9BC7BE8FEB9}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
67501002These microscopic roundworms, called <i>Caenorhabditis elegans</i>, lack eyes and the opsin proteins used by visual systems to detect colors. However, researchers found that the worms can still sense the color of light in a way that enables them to avoid pigmented toxins made by bacteria. This image was captured using a stereo microscope.3/24/2021 5:44:57 PM3/24/2021 5:44:57 PMType    Name    Media Type    File Size    Modified Ghosh et al_SciPak multimedia 1_2.24.2021_M    Medium 42 KB 3/24/2021 11:16 AM Walter, Taylor (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx28460https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{760D483D-C76B-4606-BCD1-4887E3807BC8}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6777915A 3D model of the human endoplasmic reticulum membrane protein complex (EMC) that identifies its nine essential subunits. The EMC plays an important role in making membrane proteins, which are essential for all cellular processes. This is the first atomic-level depiction of the EMC. Its structure was obtained using single-particle cryo-electron microscopy.12/6/2021 8:02:51 PM12/6/2021 8:02:51 PMType    Name    Media Type    File Size    Modified EMC_NIGMSVideoGallery-Lg    High 4824 KB 12/7/2021 10:06 AM Dolan, Lauren (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx177120https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{6B9B0617-6BFC-4A30-8D67-74F630BF8AAD}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3593802The feeding tube, or pharynx, of a planarian worm with cilia shown in red and muscle fibers shown in green10/19/2020 6:12:17 AM10/19/2020 6:12:17 AMType    Name    Media Type    File Size    Modified 3593_Isolated_Planarian_S    Low 110 KB 3/28/2019 4:09 PM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx18260https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{F9C51F8D-4481-41A5-9BB0-B389BC724927}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
1337102A humorous treatment of the concept of a cycling cell. Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.10/28/2020 8:31:27 PM10/28/2020 8:31:27 PMType    Name    Media Type    File Size    Modified ITC_BicyclingCell_Copy_S    Low 56 KB 7/28/2016 4:00 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx17170https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{0C346395-48A4-46CC-838A-C437166E6BE8}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2309301As an egg cell develops, a process called polarization controls what parts ultimately become the embryo's head and tail. This picture shows an egg of the fruit fly <i>Drosophila</i>. Red and green mark two types of signaling proteins involved in polarization. Disrupting these signals can scramble the body plan of the embryo, leading to severe developmental disorders. Featured in the September 19, 2006, issue of <a href=http://publications.nigms.nih.gov/biobeat/06-09-19/#1 target="_blank"><em>Biomedical Beat</em></a>.10/29/2020 12:54:35 PM10/29/2020 12:54:35 PMType    Name    Media Type    File Size    Modified 2309_cell_polarity_S    Low 49 KB 3/29/2019 1:54 PM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15960https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{F5BC0800-555F-4CF8-82AB-5860BD0D261E}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
5729703The HIV capsid is pear-shaped structure that is made of proteins the virus needs to mature and become infective. The capsid is inside the virus and delivers the virus' genetic information into a human cell. To better understand how the HIV capsid does this feat, scientists have used computer programs to simulate its assembly. This image shows a series of snapshots of the steps that grow the HIV capsid. A model of a complete capsid is shown on the far right of the image for comparison; the green, blue and red colors indicate different configurations of the capsid protein that make up the capsid “shell.” The bar in the left corner represents a length of 20 nanometers, which is less than a tenth the size of the smallest bacterium. Computer models like this also may be used to reconstruct the assembly of the capsids of other important viruses, such as Ebola or the Zika virus. <br><br> The studies reporting this research were published in <a href="http://www.nature.com/ncomms/2016/160513/ncomms11568/full/ncomms11568.html"><i>Nature Communications</i></a> and <a href="http://www.nature.com/nature/journal/v469/n7330/full/nature09640.html"><i>Nature</i></a>. <br><br> To learn more about how researchers used computer simulations to track the assembly of the HIV capsid, see <a href=" https://news.uchicago.edu/article/2016/06/14/simulations-describe-hivs-diabolical-delivery-device">this press release from the University of Chicago</a>.12/18/2020 4:10:47 PM12/18/2020 4:10:47 PMType    Name    Media Type    File Size    Modified HIV capsid synthesis 222px_TransparentBackground-1_S    Thumbnail 127 KB 3/20/2017 9:21 AM Machalek, Alisa STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx279110https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{C1FD6483-5B69-49FD-9F08-5665166A3E1D}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3521795Multiphoton fluorescence image of HeLa cells stained with the actin binding toxin phalloidin (red), microtubules (cyan) and cell nuclei (blue). Nikon RTS2000MP custom laser scanning microscope. See related images 3518,3519,3520,3522.9/27/2020 3:39:33 AM9/27/2020 3:39:33 AMType    Name    Media Type    File Size    Modified HeLa_cells_2_L    Low 134 KB 6/3/2016 3:30 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx17170https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{23E73D20-7634-4D67-8AE3-852B4FDFDFA8}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2523339The plasma membrane is a cell's protective barrier Featured in <a href=http://publications.nigms.nih.gov/chemhealth/ target="_blank"><i>The Chemistry of Health</i></a>.3/4/2022 8:02:56 PM3/4/2022 8:02:56 PMType    Name    Media Type    File Size    Modified Plasma_Membrane_S    Low 81 KB 8/24/2016 3:47 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx19080https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{B0AD4B41-3B4D-41DE-A541-77D481EAC9FD}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3792701What looks a little like distant planets with some mysterious surface features are actually assemblies of proteins normally found in the cell's nucleolus, a small but very important protein complex located in the cell's nucleus. It forms on the chromosomes at the location where the genes for the RNAs are that make up the structure of the ribosome, the indispensable cellular machine that make proteins from messenger RNAs. <Br><Br>However, how the nucleolus grows and maintains its structure has puzzled scientists for some time. It turns out that even though it looks like a simple liquid blob, it's rather well-organized, consisting of three distinct layers: the fibrillar center, where the RNA polymerase is active; the dense fibrillar component, which is enriched in the protein fibrillarin; and the granular component, which contains a protein called nucleophosmin. Researchers have now discovered that this multilayer structure of the nucleolus arises from differences in how the proteins in each compartment mix with water and with each other. These differences let the proteins readily separate from each other into the three nucleolus compartments.<Br><Br> This photo of nucleolus proteins in the eggs of a commonly used lab animal, the frog Xenopus laevis, shows each of the nucleolus compartments (the granular component is shown in red, the fibrillarin in yellow-green, and the fibrillar center in blue). The researchers have found that these compartments spontaneously fuse with each other on encounter without mixing with the other compartments. <Br><Br> For more details on this research, see <a href="http://www.princeton.edu/main/news/archive/S46/35/80M01/?section=topstories">this press release from Princeton</a>. Related to <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=721"> video 3789</a>, <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=722"> video 3791</a> and <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=724"> image 3793</a>.12/17/2020 7:37:00 PM12/17/2020 7:37:00 PMType    Name    Media Type    File Size    Modified Nucleolus23_L    Low 14 KB 6/3/2016 3:41 PM aamishral2 (NIH/NIGMS) [C Br><Br>However, how the nucleolus grows STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx17880https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{2B6F28C6-3C26-44A7-8B84-F2F6B05584C2}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
5768835Collecting and transporting cellular waste and sorting it into recylable and nonrecylable pieces is a complex business in the cell. One key player in that process is the endosome, which helps collect, sort and transport worn-out or leftover proteins with the help of a protein assembly called the endosomal sorting complexes for transport (or ESCRT for short). These complexes help package proteins marked for breakdown into intralumenal vesicles, which, in turn, are enclosed in multivesicular bodies for transport to the places where the proteins are recycled or dumped. In this image, a multivesicular body (the round structure slightly to the right of center) contain tiny intralumenal vesicles (with a diameter of only 25 nanometers; the round specks inside the larger round structure) adjacent to the cell's vacuole (below the multivesicular body, shown in darker and more uniform gray). <Br><Br>Scientists working with baker's yeast (Saccharomyces cerevisiae) study the budding inward of the limiting membrane (green lines on top of the yellow lines) into the intralumenal vesicles. This tomogram was shot with a Tecnai F-20 high-energy electron microscope, at 29,000x magnification, with a 0.7-nm pixel, ~4-nm resolution. <Br><Br>To learn more about endosomes, see the <i>Biomedical Beat</i> blog post <a href="https://biobeat.nigms.nih.gov/2016/07/the-cells-mailroom/">The Cell’s Mailroom</a>. Related to a <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=3074">color-enhanced version </a> of this image. Related to images 5769 and 5767.12/18/2020 6:42:00 PM12/18/2020 6:42:00 PMType    Name    Media Type    File Size    Modified WT_MVBs_at_the_Vacuole_06_M    Medium 143 KB 7/26/2016 10:54 AM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx192150https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{6DC9B4C9-6040-489C-95A3-81503E2A6917}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
5885781This image shows the structure of synapse, or junction between two nerve cells in three-dimensions. From the brain of a mouse.12/18/2020 9:53:12 PM12/18/2020 9:53:12 PMType    Name    Media Type    File Size    Modified Maximov_NIH_3 3D synapse_M    Medium 165 KB 6/1/2017 2:30 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx25780https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{F35BBD0D-1497-480F-85A0-0C0870DBF2D4}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3556670Luciferase-based imaging enables visualization and quantification of internal organs and transplanted cells in live adult zebrafish. In this image, a cardiac muscle-restricted promoter drives firefly luciferase expression. Lateral (Top) and overhead views (Bottom) are shown.10/5/2020 5:20:22 AM10/5/2020 5:20:22 AMType    Name    Media Type    File Size    Modified Poss-zebrafish-01    High 416 KB 6/3/2016 3:31 PM aamishral2 (NIH/NIGMS) [C br>For imagery of the overhead STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx29060https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{3D1F01B8-728A-4F3D-B381-CF2B50DEAA2C}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3283575This image shows neonatal mouse heart cells. These cells were grown in the lab on a chip that aligns the cells in a way that mimics what is normally seen in the body. Green shows the muscle protein toponin I. Red indicates the muscle protein actin, and blue indicates the cell nuclei. The work shown here was part of a study attempting to grow heart tissue in the lab to repair damage after a heart attack. Image and caption information courtesy of the California Institute for Regenerative Medicine.12/22/2020 10:43:51 PM12/22/2020 10:43:51 PMType    Name    Media Type    File Size    Modified Mouseheartmusclecells2_L    Low 15 KB 6/3/2016 3:25 PM aamishral2 (NIH/NIGMS) [C These cells were grown in the lab on a STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx14960https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{2499BC50-1F5B-4F3C-BBC8-8710F33CEC9B}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
1241225<i>Borrelia burgdorferi</i> is a spirochete, a class of long, slender bacteria that typically take on a coiled shape. Infection with this bacterium causes Lyme disease.3/13/2023 7:26:43 PM3/13/2023 7:26:43 PMType    Name    Media Type    File Size    Modified lyme4-neg_M    Medium 150 KB 10/28/2020 11:56 AM McCulley, Jennifer (NIH/NIDCD) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx29490https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{2477B116-D2B2-4218-8D24-A227A85CC969}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6965980As this cell was undergoing cell division, it was imaged with two microscopy techniques: differential interference contrast (DIC) and confocal. The DIC view appears in blue and shows the entire cell. The confocal view appears in pink and shows the chromosomes.1/27/2023 9:51:37 PM1/27/2023 9:51:37 PMType    Name    Media Type    File Size    Modified Dividing Cell Thumbnail    Thumbnail 1228 KB 1/27/2023 4:52 PM Bigler, Abbey (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx215170https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{CCDAC100-8DE1-4D58-8378-2F585CC18A16}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
1339104The largest human cell (by volume) is the egg. Human eggs are 150 micrometers in diameter and you can just barely see one with a naked eye. In comparison, consider the eggs of chickens...or ostriches! Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.10/29/2020 12:07:34 PM10/29/2020 12:07:34 PMType    Name    Media Type    File Size    Modified ITC_EggComp02_M    Medium 116 KB 10/29/2020 8:07 AM McCulley, Jennifer (NIH/NIDCD) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx346270https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{D7E7FAF9-C908-4EF8-8A52-9B68E55C9939}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
127592The Golgi complex, also called the Golgi apparatus or, simply, the Golgi. This organelle receives newly made proteins and lipids from the ER, puts the finishing touches on them, addresses them, and sends them to their final destinations. Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.10/28/2020 4:29:29 PM10/28/2020 4:29:29 PMType    Name    Media Type    File Size    Modified ITC_Golgi_inset_Copy_M    Medium 28 KB 10/28/2020 12:29 PM McCulley, Jennifer (NIH/NIDCD) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx4309250https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{F1ACB139-25A3-4C54-8EE3-575084FC6DB6}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
67981013Yeast cells with nuclear envelopes shown in magenta and tubulin shown in light blue. The nuclear envelope defines the borders of the nucleus, which houses DNA. Tubulin is a protein that makes up microtubules—strong, hollow fibers that provide structure to cells and help direct chromosomes during cell division. This image was captured using wide-field microscopy with deconvolution. <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6791">6791</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6792">6792</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6793">6793</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6794">6794</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6797">6797</a>, and videos <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6795">6795</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6796">6796</a>.7/17/2023 5:07:46 PM7/17/2023 5:07:46 PMType    Name    Media Type    File Size    Modified YeastCells8_M    Low 19 KB 1/28/2022 2:22 PM Dolan, Lauren (NIH/NIGMS) [C Permission email: Hi Abbey, My name STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx217150https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{3BE03231-0BFB-4A6D-93AC-9F52ADA3C1C4}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3567604Viral RNA (red) in an RSV-infected cell. More information about the research behind this image can be found in a <a href="http://biobeat.nigms.nih.gov/2014/01/cool-image-visualizing-viral-activity/">Biomedical Beat Blog posting</a> from January 2014.10/5/2020 5:40:18 AM10/5/2020 5:40:18 AMType    Name    Media Type    File Size    Modified RSV-infected_cell_L    Low 11 KB 6/3/2016 3:32 PM aamishral2 (NIH/NIGMS) [C You are welcome to use the image (attached is a 300 dpi TIFF) with the STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx190110https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{C036CB5E-A217-4790-A046-FB98CA16504C}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3488665Shiga toxin (green) is sorted from the endosome into membrane tubules (red), which then pinch off and move to the Golgi apparatus.9/8/2020 11:05:30 PM9/8/2020 11:05:30 PMType    Name    Media Type    File Size    Modified Manganese    Other 94 KB 9/26/2020 10:23 PM Harris, Donald (NIH/NIGMS) [C We would like to add the image STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx182110https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{05966EB7-4653-4C31-8BCB-559E2C254C44}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3559673Luciferase-based imaging enables visualization and quantification of internal organs and transplanted cells in live adult zebrafish. This image shows how luciferase-based imaging could be used to visualize the heart for regeneration studies (left), or label all tissues for stem cell transplantation (right).10/5/2020 5:27:55 AM10/5/2020 5:27:55 AMType    Name    Media Type    File Size    Modified Poss-zebrafish-04_L    Low 35 KB 6/3/2016 3:31 PM aamishral2 (NIH/NIGMS) [C br>For imagery of both the STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx22880https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{7E206F11-67B8-4B43-BEA6-8DD760F163C4}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3387451Spinal nerves are part of the peripheral nervous system. They run within the spinal column to carry nerve signals to and from all parts of the body. The spinal nerves enable all the movements we do, from turning our heads to wiggling our toes, control the movements of our internal organs, such as the colon and the bladder, as well as allow us to feel touch and location of our limbs.12/23/2020 8:04:47 PM12/23/2020 8:04:47 PMType    Name    Media Type    File Size    Modified NCMIR_human_spinal_nerve_L    Low 30 KB 6/3/2016 3:27 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx206100https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{64E261D1-CBF3-4145-AB2D-8F5C90A18B68}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6898882A crane fly spermatocyte during metaphase of meiosis-I, a step in the production of sperm. A meiotic spindle pulls apart three pairs of autosomal chromosomes, along with a sex chromosome on the right. Tubular mitochondria surround the spindle and chromosomes. This video was captured with quantitative orientation-independent differential interference contrast and is a time lapse showing a 1-second image taken every 30 seconds over the course of 30 minutes. <Br><Br> More information about the research that produced this video can be found in the <em>J. Biomed Opt.</em> paper <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2302836/">“Orientation-Independent Differential Interference Contrast (DIC) Microscopy and Its Combination with Orientation-Independent Polarization System”</a> by Shribak et. al. 6/30/2022 4:43:19 PM6/30/2022 4:43:19 PMType    Name    Media Type    File Size    Modified CraneFlymovie    High 15196 KB 6/30/2022 2:59 PM Bigler, Abbey (NIH/NIGMS) [C Yes, I give my permission to add the three STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx254100https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{15FD877D-8727-48A0-A2F1-9A1B8CCD20F0}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3386522The human immunodeficiency virus (HIV),shown here as tiny purple spheres, causes the disease known as AIDS (for acquired immunodeficiency syndrome). HIV can infect multiple cells in your body, including brain cells, but its main target is a cell in the immune system called the CD4 lymphocyte (also called a T-cell or CD4 cell).12/23/2020 8:03:30 PM12/23/2020 8:03:30 PMType    Name    Media Type    File Size    Modified NCMIR_HIV_infected_cell    High 254 KB 6/3/2016 3:27 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx193110https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{3D7073C8-3290-4F3B-9B48-714CBFC2BE59}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
69021018An <em> Arachnoidiscus</em> diatom with a diameter of 190µm. Diatoms are microscopic algae that have cell walls made of silica, which is the strongest known biological material relative to its density. In <em> Arachnoidiscus</em>, the cell wall is a radially symmetric pillbox-like shell composed of overlapping halves that contain intricate and delicate patterns. Sometimes, <em> Arachnoidiscus</em> is called “a wheel of glass.” <Br><Br> This image was taken with the orientation-independent differential interference contrast microscope. 7/13/2022 8:00:33 PM7/13/2022 8:00:33 PMType    Name    Media Type    File Size    Modified Fourth of July_S    Low 40 KB 7/13/2022 4:09 PM Bigler, Abbey (NIH/NIGMS) [C Fourth of July    High 213 KB STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx275170https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{061D17CD-3B20-4996-B7BC-CC797BDA0A6D}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3490595On top, the brain of a sleep-deprived fly glows orange because of Bruchpilot, a communication protein between brain cells. These bright orange brain areas are associated with learning. On the bottom, a well-rested fly shows lower levels of Bruchpilot, which might make the fly ready to learn after a good night's rest.9/8/2020 11:16:35 PM9/8/2020 11:16:35 PMType    Name    Media Type    File Size    Modified 3490_coolimagecirelli_S    Low 203 KB 3/28/2019 4:29 PM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx17370https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{2D0B0671-BBE2-4FE5-AC8F-0F260E2BEC01}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
1056215Cross-section of skin anatomy shows layers and different tissue types.8/14/2020 6:17:32 PM8/14/2020 6:17:32 PMType    Name    Media Type    File Size    Modified 300skin_S    Low 39 KB 7/27/2016 11:50 AM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx3899100https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{73490105-234B-442A-8E63-4A41597D14B1}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3576608Here, bubonic plague bacteria (yellow) are shown in the digestive system of a rat flea (purple). The bubonic plague killed a third of Europeans in the mid-14th century. Today, it is still active in Africa, Asia and the Americas, with as many as 2,000 people infected worldwide each year. If caught early, bubonic plague can be treated with antibiotics. This image is part of the Life: Magnified collection, which was displayed in the Gateway Gallery at Washington Dulles International Airport June 3, 2014, to January 21, 2015. To see all 46 images in this exhibit, go to https://www.nigms.nih.gov/education/life-magnified/Pages/default.aspx.11/28/2022 9:43:00 PM11/28/2022 9:43:00 PMType    Name    Media Type    File Size    Modified Yersina_pestis_1_H    High 4674 KB 10/5/2020 2:04 AM Harris, Donald (NIH/NIGMS) [C Br><Br> This image was part of the <em STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx20290https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{1DA06FC3-2FA7-4A59-B108-BBB3DD8ACB3F}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3557671Luciferase-based imaging enables visualization and quantification of internal organs and transplanted cells in live adult zebrafish. In this image, a cardiac muscle-restricted promoter drives firefly luciferase expression (overhead view).10/5/2020 5:19:11 AM10/5/2020 5:19:11 AMType    Name    Media Type    File Size    Modified Poss-zebrafish-02_L    Low 20 KB 6/3/2016 3:31 PM aamishral2 (NIH/NIGMS) [C br>For imagery of both the STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx28790https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{E71A3B27-F195-440D-B17B-B07940F5C51C}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6971930Multicellular yeast called snowflake yeast that researchers created through many generations of directed evolution from unicellular yeast. Here, the researchers visualized nuclei in orange to help them study changes in how the yeast cells divided. Cell walls are shown in blue. This image was captured using spinning disk confocal microscopy. <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6969">6969</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6970">6970</a>.7/17/2023 4:45:39 PM7/17/2023 4:45:39 PMType    Name    Media Type    File Size    Modified Snowflake Yeast 3_M    Medium 153 KB 2/3/2023 4:59 PM Bigler, Abbey (NIH/NIGMS) [C He is the one who took the STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx283120https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{C9C3375E-C0DC-412C-A8F3-E90FE2BF5648}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2702488A combo of protein structures determined experimentally and computationally shows us the complete metabolic network of a heat-loving bacterium.8/6/2020 4:36:05 PM8/6/2020 4:36:05 PMType    Name    Media Type    File Size    Modified 2702_Thermotoga_maritima_and_its_metabolic_network_T    Thumbnail 97 KB 3/29/2019 11:00 AM Constantinides STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx18870https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{8BCB0A5C-8081-41B2-AEC1-62DCCD78EE99}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2741363Like a strand of white pearls, DNA wraps around an assembly of special proteins called histones (colored) to form the nucleosome, a structure responsible for regulating genes and condensing DNA strands to fit into the cell's nucleus. Researchers once thought that nucleosomes regulated gene activity through their histone tails (dotted lines), but a 2010 study revealed that the structures' core also plays a role. The finding sheds light on how gene expression is regulated and how abnormal gene regulation can lead to cancer. Featured in the May 19, 2010, issue of <a href=http://publications.nigms.nih.gov/biobeat/10-05-19/index.html#1 target="_blank"><em>Biomedical Beat</em></a>.8/18/2020 6:57:42 PM8/18/2020 6:57:42 PMType    Name    Media Type    File Size    Modified Inside_the_nucleosome_L    Low 13 KB 6/3/2016 3:16 PM aamishral2 (NIH/NIGMS) [C Like a strand of white pearls STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx195100https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{C3ADC02D-DA98-4D44-899B-1EA1E1D08A0A}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3789699The nucleolus is a small but very important protein complex located in the cell's nucleus. It forms on the chromosomes at the location where the genes for the RNAs are that make up the structure of the ribosome, the indispensable cellular machine that make proteins from messenger RNAs.<Br><Br> However, how the nucleolus grows and maintains its structure has puzzled scientists for some time. It turns out that even though it looks like a simple liquid blob, it's rather well-organized, consisting of three distinct layers: the fibrillar center, where the RNA polymerase is active; the dense fibrillar component, which is enriched in the protein fibrillarin; and the granular component, which contains a protein called nucleophosmin. Researchers have now discovered that this multilayer structure of the nucleolus arises from difference in how the proteins in each compartment mix with water and with each other. These differences let them readily separate from each other into the three nucleolus compartments. <Br><Br>This video of nucleoli in the eggs of a commonly used lab animal, the frog Xenopus laevis, shows how each of the compartments (the granular component is shown in red, the fibrillarin in yellow-green, and the fibrillar center in blue) spontaneously fuse with each other on encounter without mixing with the other compartments. For more details on this research, see <a href="http://www.princeton.edu/main/news/archive/S46/35/80M01/?section=topstories">this press release from Princeton.</a> Related to <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=721"> video 3791</a>, <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=722"> image 3792</a> and <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=723"> image 3793</a>.12/17/2020 7:25:03 PM12/17/2020 7:25:03 PMType    Name    Media Type    File Size    Modified Composite_combo_label    High 746 KB 6/28/2016 3:33 PM Hall, Monique (NIH/NCI) [C Please let me know if you STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx199100https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{8A8A26C8-4CB6-481F-972E-8E85FDE07585}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2605354The human skin cells pictured contain genetic modifications that make them pluripotent, essentially equivalent to embryonic stem cells. A scientific team from the University of Wisconsin-Madison including researchers Junying Yu, James Thomson, and their colleagues produced the transformation by introducing a set of four genes into human fibroblasts, skin cells that are easy to obtain and grow in culture.10/30/2020 7:28:55 PM10/30/2020 7:28:55 PMType    Name    Media Type    File Size    Modified skin_cell_pluripotent07_1_M    Medium 364 KB 7/27/2016 11:39 AM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx192100https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{846B41F6-0AAB-4160-9A8B-EF6F0C6272D7}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131