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2757495The fly fatbody is a nutrient storage and mobilization organ akin to the mammalian liver. The engulfment receptor Draper (green) is located at the cell surface of fatbody cells. The cell nuclei are shown in blue.8/21/2020 7:22:13 PM8/21/2020 7:22:13 PMType    Name    Media Type    File Size    Modified Drpr-Stain-Fatbody_S    Low 15 KB 9/14/2016 11:23 AM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13260https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{82EDCB5C-6659-4D5D-BB11-115D5E51E39A}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3619613After multiplying inside a host cell, the stringlike Ebola virus is emerging to infect more cells. Ebola is a rare, often fatal disease that occurs primarily in tropical regions of sub-Saharan Africa. The virus is believed to spread to humans through contact with wild animals, especially fruit bats. It can be transmitted between one person and another through bodily fluids. This image is part of the Life: Magnified collection, which was displayed in the Gateway Gallery at Washington Dulles International Airport June 3, 2014, to January 21, 2015. To see all 46 images in this exhibit, go to https://www.nigms.nih.gov/education/life-magnified/Pages/default.aspx.11/22/2022 8:33:21 PM11/22/2022 8:33:21 PMType    Name    Media Type    File Size    Modified 7_topleft_Ebola_2-ZEBOV_Vero_E6_ATCC_72h_m021_L    Low 247 KB 6/3/2016 3:34 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx12770https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{0E4D5E79-C23A-4BA4-BB9A-4CF2B42CE408}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3449788Living primary mouse embryonic fibroblasts. Mitochondria (green) stained with the mitochondrial membrane potential indicator, rhodamine 123. Nuclei (blue) are stained with DAPI. Caption from a November 26, 2012 <a href= "http://www.uphs.upenn.edu/news/News_Releases/2012/11/energy/">news release </a> from U Penn (Penn Medicine).8/22/2020 6:35:39 PM8/22/2020 6:35:39 PMType    Name    Media Type    File Size    Modified From: Kevin Foskett [mailto:foskett@mail.med.upenn.edu] Sent: Wednesday, May 15, 2013 11:14 AM To: Kreeger, Karen Subject: Re: Permission from NIGMS STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13660https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{B8716C1C-A233-4176-8164-F8FDF7922338}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3442588These images show three stages of cell division in Xenopus XL177 cells, which are derived from tadpole epithelial cells. They are (from top): metaphase, anaphase and telophase. The microtubules are green and the chromosomes are blue. Related to <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3443">image 3443</a>.8/22/2020 5:25:02 PM8/22/2020 5:25:02 PMType    Name    Media Type    File Size    Modified mitotic1_M    Medium 94 KB 6/3/2016 3:29 PM aamishral2 (NIH/NIGMS) [C These images show three stages of cell division in Xenopus XL177 cells, which are derived from tadpole STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13360https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{385F83B3-C956-487B-9A75-4C353F0A940E}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3574607Scientists have long known that multicellular organisms use biological molecules produced by one cell and sensed by another to transmit messages that, for instance, guide proper development of organs and tissues. But it's been a puzzle as to how molecules dumped out into the fluid-filled spaces between cells can precisely home in on their targets.<br> Using living tissue from fruit flies, a team led by Thomas Kornberg of the University of California, San Francisco, has shown that typical cells in animals can talk to each other via long, thin cell extensions called cytonemes (Latin for "cell threads") that may span the length of 50 or 100 cells. The point of contact between a cytoneme and its target cell acts as a communications bridge between the two cells.<br> More information about the research behind this image can be found in a <a href="http://biobeat.nigms.nih.gov/2014/02/animal-cells-reach-out-and-touch-to-communicate/" target=_blank>Biomedical Beat </a>Blog posting from February 2014.10/5/2020 5:54:08 AM10/5/2020 5:54:08 AMType    Name    Media Type    File Size    Modified Kornberg_cytonemes    High 265 KB 6/3/2016 3:32 PM aamishral2 (NIH/NIGMS) [C The point of contact between a STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13180https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{BCBF4841-8141-4D12-8A5C-3CC4EDA6C3C5}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3272373Mouse embryonic stem cells matured into this bundle of hair cells similar to the ones that transmit sound in the ear. These cells could one day be transplanted as a therapy for some forms of deafness, or they could be used to screen drugs to treat deafness. The hairs are shown at 23,000 times magnification via scanning electron microscopy. Image and caption information courtesy of the California Institute for Regenerative Medicine.12/22/2020 6:25:08 PM12/22/2020 6:25:08 PMType    Name    Media Type    File Size    Modified EarhaircellfromEScells_L    Low 7 KB 6/3/2016 3:25 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx118100https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{A5C36457-F659-42BA-B403-50E555124A5F}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6983884Fat tissue from the abdomen of a genetically mosaic adult fruit fly. Genetic mosaicism means that the fly has cells with different genotypes even though it formed from a single zygote. This specific mosaicism results in accumulation of a critical fly adipokine (blue-green) within the fat tissue cells that have reduced expression a key nutrient sensing gene (in left panel). The dotted line shows the cells lacking the gene that is present and functioning in the rest of the cells. Nuclei are labelled in magenta. This image was captured using a confocal microscope and shows a maximum intensity projection of many slices. <Br><Br>Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6982">6982</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6984">6984</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6985">6985</a>. 12/19/2023 7:15:52 PM12/19/2023 7:15:52 PMType    Name    Media Type    File Size    Modified This image was captured using a confocal microscope and shows a maximum intensity projection of many slices STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx219120https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{3AA16265-C3FB-43F6-92DA-0F6B21B387B3}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6985886<em> Drosophila </em> adult brain showing that an adipokine (fat hormone) generates a response from neurons (aqua) and regulates insulin-producing neurons (red). <Br><Br>Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6982">6982</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6983">6983</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6984">6984</a>.12/19/2023 9:06:13 PM12/19/2023 9:06:13 PMType    Name    Media Type    File Size    Modified Since the images are too large to attach I have uploaded them at this google drive link and you should be able to download it the link STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx216140https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{B16A02E1-AF2B-43FE-A6EC-37FF25432F66}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2637552A scanning electron microscope image of an activated mast cell. This image illustrates the interesting topography of the cell membrane, which is populated with receptors. The distribution of receptors may affect cell signaling. This image relates to a July 27, 2009, <a href=http://publications.nigms.nih.gov/computinglife/cells_circuits.htm target="_blank">article in <em>Computing Life</em></a>.11/6/2020 9:07:57 PM11/6/2020 9:07:57 PMType    Name    Media Type    File Size    Modified 2637_rblactiveshad_S    Low 85 KB 3/29/2019 11:05 AM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx11950https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{421A90EE-2D34-4873-9436-3DCFB980CD0D}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6352720This image shows how the CRISPR surveillance complex is disabled by two copies of anti-CRISPR protein AcrF1 (red) and one AcrF2 (light green). These anti-CRISPRs block access to the CRISPR RNA (green tube) preventing the surveillance complex from scanning and targeting invading viral DNA for destruction. 12/21/2020 5:09:58 PM12/21/2020 5:09:58 PMType    Name    Media Type    File Size    Modified CRISPR 2 of 2 NRAMM    High 197 KB 11/29/2017 11:59 AM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13350https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{152D7892-75BF-4DA9-913D-B1FCC618DA85}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3332384Cells move forward with lamellipodia and filopodia supported by networks and bundles of actin filaments. Proper, controlled cell movement is a complex process. Recent research has shown that an actin-polymerizing factor called the Arp2/3 complex is the key component of the actin polymerization engine that drives amoeboid cell motility. ARPC3, a component of the Arp2/3 complex, plays a critical role in actin nucleation. In this photo, the ARPC3+/+ fibroblast cells were fixed and stained with Alexa 546 phalloidin for F-actin (red) and DAPI to visualize the nucleus (blue). ARPC3+/+ fibroblasts cells with lamellipodia leading edge. Related information available in a Stowers Institute <a href=http://www.stowers.org/media/news/apr-9-2012 target="_blank"> news release</a>. This image is part of a series of images; related to <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3328">image 3328</a> , <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3329">image 3329</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3330">image 3330</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3331">image 3331</a> and <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3333">image 3333</a>.12/23/2020 5:30:53 PM12/23/2020 5:30:53 PMType    Name    Media Type    File Size    Modified Pic-_5a_2_rs_S    Low 6 KB 3/23/2021 11:49 AM Walter, Taylor (NIH/NIGMS) [C In this photo, the ARPC3+/+ fibroblast cells were fixed and stained with STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx11160https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{594A54CB-CF70-4918-B9C1-672340343B0C}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3434400Influenza (flu) virus proteins in the act of self-replication. Viral nucleoprotein (blue) encapsidates [encapsulates] the RNA genome (green). The influenza virus polymerase (orange) reads and copies the RNA genome. In the background is an image of influenza virus ribonucleoprotein complexes observed using cryo-electron microscopy. This image is from a November 2012 <a href=http://www.eurekalert.org/pub_releases/2012-11/sri-sri112012.php target="blank"> <em>News Release</em></a>.8/22/2020 4:28:48 PM8/22/2020 4:28:48 PMType    Name    Media Type    File Size    Modified Flu_virus_proteins_    High 660 KB 6/3/2016 3:29 PM aamishral2 (NIH/NIGMS) [C In the background is an image STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13540https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{77F0053D-8191-4175-9D50-055CE49F083C}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6521989This skyline of New York City was created by “printing” nanodroplets containing yeast (<i>Saccharomyces cerevisiae</i>) onto a large plate. Each dot is a separate yeast colony. As the colonies grew, a picture emerged, creating art. To make the different colors shown here, yeast strains were genetically engineered to produce pigments naturally made by bacteria, fungi, and sea creatures such as coral and sea anemones. Using genes from other organisms to make biological compounds paves the way toward harnessing yeast in the production of other useful molecules, from food to fuels and drugs.12/22/2020 4:10:18 PM12/22/2020 4:10:18 PMType    Name    Media Type    File Size    Modified NYC Skyline, FASEB winner_HIghRes    High 2636 KB 11/6/2019 10:14 AM Harris, Donald (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13440https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{7761567D-1F40-428F-B2A5-DC64D0AEB797}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
7023892Dynein (green) is a motor protein that “walks” along microtubules (red, part of the cytoskeleton) and carries its cargo along with it. This video was captured through fluorescence microscopy. 5/20/2024 1:55:04 PM5/20/2024 1:55:04 PMType    Name    Media Type    File Size    Modified TIRF_motility_movie (2)    High 18389 KB 5/22/2024 2:19 PM aamershaha (NIH/NIGMS) [C It was acquired in my lab here at the STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx10140https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{3C9819B5-9560-444A-BB29-3C4FBF0844A2}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2452201Cdc42, a member of the Rho family of small guanosine triphosphatase (GTPase) proteins, regulates multiple cell functions, including motility, proliferation, apoptosis, and cell morphology. In order to fulfill these diverse roles, the timing and location of Cdc42 activation must be tightly controlled. Klaus Hahn and his research group use special dyes designed to report protein conformational changes and interactions, here in living neutrophil cells. Warmer colors in this image indicate higher levels of activation. Cdc42 looks to be activated at cell protrusions.5/9/2022 1:34:32 PM5/9/2022 1:34:32 PMType    Name    Media Type    File Size    Modified whole_cell_2    High 611 KB 6/3/2016 3:11 PM aamishral2 (NIH/NIGMS) [C Warmer colors in this image indicate STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx12350https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{9DE4D092-49B1-4B56-947A-F66CFCF79C41}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2438265<i>Hydra magnipapillata</i> is an invertebrate animal used as a model organism to study developmental questions, for example the formation of the body axis.5/1/2024 8:28:14 PM5/1/2024 8:28:14 PMType    Name    Media Type    File Size    Modified D20_2921-2    High 1545 KB 6/3/2016 3:11 PM aamishral2 (NIH/NIGMS) [C I sent the images for that purpose STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13840https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{6730514F-C4E7-47BE-9D58-176F790A5EED}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2603352These cells are induced stem cells made from human adult skin cells that were genetically reprogrammed to mimic embryonic stem cells. The induced stem cells were made potentially safer by removing the introduced genes and the viral vector used to ferry genes into the cells, a loop of DNA called a plasmid. The work was accomplished by geneticist Junying Yu in the laboratory of James Thomson, a University of Wisconsin-Madison School of Medicine and Public Health professor and the director of regenerative biology for the Morgridge Institute for Research.10/30/2020 7:27:01 PM10/30/2020 7:27:01 PMType    Name    Media Type    File Size    Modified Thomson_IPS_cells09_A2_S    Low 130 KB 9/7/2016 12:18 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx10950https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{E03BEE59-AC52-40DE-A0AE-58F58F2D5D99}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2537472The G switch allows our bodies to respond rapidly to hormones. G proteins act like relay batons to pass messages from circulating hormones into cells. A hormone (red) encounters a receptor (blue) in the membrane of a cell. Next, a G protein (green) becomes activated and makes contact with the receptor to which the hormone is attached. Finally, the G protein passes the hormone's message to the cell by switching on a cell enzyme (purple) that triggers a response. See image 2536 and 2538 for other versions of this image. Featured in <a href=http://publications.nigms.nih.gov/medbydesign/ target="_blank"><i>Medicines By Design</i></a>.10/9/2020 4:46:41 PM10/9/2020 4:46:41 PMType    Name    Media Type    File Size    Modified The_G_Switch_S    Low 50 KB 8/24/2016 3:06 PM Varkala, Venkat (NIH/NIGMS) [C See image 2536 and 2538 for STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx12540https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{24697F49-DC4B-4FD7-BE6B-757DE3616E6B}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3287507This image shows a layer of retinal pigment epithelium cells derived from human embryonic stem cells, highlighting the nuclei (red) and cell surfaces (green). This kind of retinal cell is responsible for macular degeneration, the most common cause of blindness. Image and caption information courtesy of the California Institute for Regenerative Medicine.12/22/2020 10:50:24 PM12/22/2020 10:50:24 PMType    Name    Media Type    File Size    Modified 3287_Retinalpigmentepithelium02_S    Low 204 KB 3/29/2019 10:38 AM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx16040https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{E406EE03-5081-4F98-B478-B6C42E410963}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3290510The three neurons (red) visible in this image were derived from human embryonic stem cells. Undifferentiated stem cells are green here. Image and caption information courtesy of the California Institute for Regenerative Medicine.12/22/2020 10:53:14 PM12/22/2020 10:53:14 PMType    Name    Media Type    File Size    Modified 3290_ThreeneuronsandEScells_S    Low 112 KB 3/29/2019 10:37 AM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx12240https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{1F2909E8-5F2F-4014-BE3C-C7C752EC9DF9}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3386522The human immunodeficiency virus (HIV),shown here as tiny purple spheres, causes the disease known as AIDS (for acquired immunodeficiency syndrome). HIV can infect multiple cells in your body, including brain cells, but its main target is a cell in the immune system called the CD4 lymphocyte (also called a T-cell or CD4 cell).12/23/2020 8:03:30 PM12/23/2020 8:03:30 PMType    Name    Media Type    File Size    Modified NCMIR_HIV_infected_cell    High 254 KB 6/3/2016 3:27 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx14560https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{3D7073C8-3290-4F3B-9B48-714CBFC2BE59}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3279571These induced pluripotent stem cells (iPS cells) were derived from a woman's skin. Blue show nuclei. Green show a protein found in iPS cells but not in skin cells (NANOG). The red dots show the inactivated X chromosome in each cell. These cells can develop into a variety of cell types. Image and caption information courtesy of the California Institute for Regenerative Medicine.12/22/2020 7:32:20 PM12/22/2020 7:32:20 PMType    Name    Media Type    File Size    Modified iPScells2_L    Low 10 KB 6/3/2016 3:25 PM aamishral2 (NIH/NIGMS) [C These induced pluripotent stem cells (iPS cells) were derived from a woman's STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx11740https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{BCE846C4-1C1B-4941-A5B7-369FFEB5562C}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3283575This image shows neonatal mouse heart cells. These cells were grown in the lab on a chip that aligns the cells in a way that mimics what is normally seen in the body. Green shows the muscle protein toponin I. Red indicates the muscle protein actin, and blue indicates the cell nuclei. The work shown here was part of a study attempting to grow heart tissue in the lab to repair damage after a heart attack. Image and caption information courtesy of the California Institute for Regenerative Medicine.12/22/2020 10:43:51 PM12/22/2020 10:43:51 PMType    Name    Media Type    File Size    Modified Mouseheartmusclecells2_L    Low 15 KB 6/3/2016 3:25 PM aamishral2 (NIH/NIGMS) [C These cells were grown in the lab on a STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx12140https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{2499BC50-1F5B-4F3C-BBC8-8710F33CEC9B}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
5825714A growing Vibrio cholerae (cholera) biofilm. Cholera bacteria form colonies called biofilms that enable them to resist antibiotic therapy within the body and other challenges to their growth. <br></br>Each slightly curved comma shape represents an individual bacterium from assembled confocal microscopy images. Different colors show each bacterium’s position in the biofilm in relation to the surface on which the film is growing. 3/3/2021 5:54:14 PM3/3/2021 5:54:14 PMType    Name    Media Type    File Size    Modified Jing_Bassler_biofilm    High 133 KB 3/3/2021 12:52 PM Walter, Taylor (NIH/NIGMS) [C Please let me know if you STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx12340https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{6EE99145-4496-41A4-ADB7-FB7D122F4F07}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3590800Developing spermatids (precursors of mature sperm cells) begin as small, round cells and mature into long-tailed, tadpole-shaped ones. In the sperm cell's head is the cell nucleus; in its tail is the power to outswim thousands of competitors to fertilize an egg. As seen in this microscopy image, fruit fly spermatids start out as bouquets of interconnected cells. A small lipid molecule called PIP2 helps spermatids tell their heads from their tails. Here, PIP2 (red) marks the nuclei and a cell skeleton-building protein called tubulin (green) marks the tails. When PIP2 levels are too low, some spermatids get mixed up and grow with their heads at the wrong end. Because sperm development is similar across species, studies in fruit flies could help researchers understand male infertility in humans.8/23/2023 2:01:13 PM8/23/2023 2:01:13 PMType    Name    Media Type    File Size    Modified Fabian_et_al-cover_pic_1-RGB2    Other 10234 KB 10/19/2020 1:52 AM Harris, Donald (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx14240https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{1E653F9B-A3DB-4BB0-AC1F-1A9089E37998}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
5764831This illustration shows pathogenic bacteria behave like a Trojan horse: switching from antibiotic susceptibility to resistance during infection. Salmonella are vulnerable to antibiotics while circulating in the blood (depicted by fire on red blood cell) but are highly resistant when residing within host macrophages. This leads to treatment failure with the emergence of drug-resistant bacteria.<Br><Br> This image was chosen as a winner of the 2016 NIH-funded research image call, and the research was funded in part by NIGMS.12/18/2020 5:59:09 PM12/18/2020 5:59:09 PMType    Name    Media Type    File Size    Modified 26831610894_f3d948c0d7_o_M    Medium 208 KB 7/21/2016 2:16 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx14340https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{B1628989-49A2-4E4E-9A41-17D6459B80DF}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6534942In the worm <i>C. elegans</i>, double-stranded RNA made in neurons can silence matching genes in a variety of cell types through the transport of RNA between cells. The head region of three worms that were genetically modified to express a fluorescent protein were imaged and the images were color-coded based on depth. The worm on the left lacks neuronal double-stranded RNA and thus every cell is fluorescent. In the middle worm, the expression of the fluorescent protein is silenced by neuronal double-stranded RNA and thus most cells are not fluorescent. The worm on the right lacks an enzyme that amplifies RNA for silencing. Surprisingly, the identities of the cells that depend on this enzyme for gene silencing are unpredictable. As a result, worms of identical genotype are nevertheless random mosaics for how the function of gene silencing is carried out. For more, see <a href="https://academic.oup.com/nar/article/47/19/10059/5563947">journal article</a> and <a href="https://umdrightnow.umd.edu/news/umd-scientists-discover-hidden-differences-may-help-cells-evade-drug-therapy">press release.</a> Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6532">6532</a>.12/21/2020 7:47:07 PM12/21/2020 7:47:07 PMType    Name    Media Type    File Size    Modified The_Three_Pharingos_16colored_Thumbnail    Thumbnail 91 KB 12/17/2019 2:58 PM Harris, Donald (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx10940https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{41A91E05-BA3D-46C3-9B56-0838552A4F30}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6806969The two large, central, round shapes are ovaries from a typical fruit fly (<em>Drosophila melanogaster</em>). The small butterfly-like structures surrounding them are fruit fly ovaries where researchers suppressed the expression of a gene that controls microtubule polymerization and is necessary for normal development. This image was captured using a confocal laser scanning microscope. <Br><Br> Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6807">6807</a>. 1/21/2022 3:55:03 PM1/21/2022 3:55:03 PMType    Name    Media Type    File Size    Modified Wild-type and mutant fruit fly ovaries_M    Medium 119 KB 2/11/2022 1:44 PM Dolan, Lauren (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx16440https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{1CE96574-AF64-43B2-8987-EDADC4899FE7}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
67541006In many animals, the egg cell develops alongside sister cells. These sister cells are called nurse cells in the fruit fly (<em>Drosophila melanogaster</em>), and their job is to “nurse” an immature egg cell, or oocyte. Toward the end of oocyte development, the nurse cells transfer all their contents into the oocyte in a process called nurse cell dumping. This video captures this transfer, showing significant shape changes on the part of the nurse cells (blue), which are powered by wavelike activity of the protein myosin (red). Researchers created the video using a confocal laser scanning microscope. Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6753">6753</a>.7/20/2021 3:43:33 PM7/20/2021 3:43:33 PMType    Name    Media Type    File Size    Modified Fruit fly nurse cell video (1)    High 23777 KB 3/25/2021 4:51 PM Walter, Taylor (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13440https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{832C5196-E92F-48A5-B7CD-AF878621F7A3}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2435263The glial cells (black dots) and nerve cells (brown bands) in this developing fruit fly nerve cord formed normally despite the absence of the SPITZ protein, which blocks their impending suicide. The HID protein, which triggers suicide, is also lacking in this embryo.8/19/2020 4:24:57 PM8/19/2020 4:24:57 PMType    Name    Media Type    File Size    Modified Developing_fruit_fly_nerve_cord    High 48 KB 6/3/2016 3:11 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx10850https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{DF2ABB73-C6AA-445B-9DE5-B16A7830BDE9}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2419324This image of the human brain uses colors and shapes to show neurological differences between two people. The blurred front portion of the brain, associated with complex thought, varies most between the individuals. The blue ovals mark areas of basic function that vary relatively little. Visualizations like this one are part of a project to map complex and dynamic information about the human brain, including genes, enzymes, disease states, and anatomy. The brain maps represent collaborations between neuroscientists and experts in math, statistics, computer science, bioinformatics, imaging, and nanotechnology. Featured in the October 18, 2005, issue of <a href="http://publications.nigms.nih.gov/biobeat/05-10-18/#1" target="_blank"><em>Biomedical Beat</em></a>.5/12/2021 8:58:25 PM5/12/2021 8:58:25 PMType    Name    Media Type    File Size    Modified Brain_map_M    Medium 67 KB 6/3/2016 3:10 PM aamishral2 (NIH/NIGMS) [C This image of the human brain uses STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13150https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{B082809A-5B3D-4BD2-B182-2FFDA2EBAE5B}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3440587During embryonic development, transcription factors (proteins that regulate gene expression) govern the differentiation of cells into separate tissues and organs. Researchers at Cincinnati Children's Hospital Medical Center used mice to study the development of certain internal organs, including the liver, pancreas, duodenum (beginning part of the small intestine), gall bladder and bile ducts. They discovered that transcription factor Sox17 guides some cells to develop into liver cells and others to become part of the pancreas or biliary system (gall bladder, bile ducts and associated structures). The separation of these two distinct cell types (liver versus pancreas/biliary system) is complete by embryonic day 8.5 in mice. The transcription factors PDX1 and Hes1 are also known to be involved in embryonic development of the pancreas and biliary system. This image shows mouse cells at embryonic day 10.5. The green areas show cells that will develop into the pancreas and/or duodenum(PDX1 is labeled green). The blue area near the bottom will become the gall bladder and the connecting tubes (common duct and cystic duct) that attach the gall bladder to the liver and pancreas (Sox17 is labeled blue). The transcription factor Hes1 is labeled red. The image was not published. A similar image (different plane of the section) was published in: <b>Sox17 Regulates Organ Lineage Segregation of Ventral Foregut Progenitor Cells</b> Jason R. Spence, Alex W. Lange, Suh-Chin J. Lin, Klaus H. Kaestner, Andrew M. Lowy, Injune Kim, Jeffrey A. Whitsett and James M. Wells, Developmental Cell, Volume 17, Issue 1, 62-74, 21 July 2009. doi:10.1016/j.devcel.2009.05.0128/22/2020 5:03:27 PM8/22/2020 5:03:27 PMType    Name    Media Type    File Size    Modified e10-5_sox_hes_pdx    Other 26400 KB 9/26/2020 10:34 PM Harris, Donald (NIH/NIGMS) [C If so, and if it?s not STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx11470https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{82850322-6E67-4E74-9AB5-AA92C974E1F0}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3613678Cells missing a key molecule look spiky and cannot move normally. This is a fibroblast, a connective tissue cell that plays an important role in wound healing. Normal fibroblasts have smooth edges. In contrast, this spiky cell is missing a protein that is necessary for proper construction of the cell's skeleton. Its jagged shape makes it impossible for the cell to move normally. In addition to compromising wound healing, abnormal cell movement can lead to birth defects, faulty immune function and other health problems. This image is part of the Life: Magnified collection, which was displayed in the Gateway Gallery at Washington Dulles International Airport June 3, 2014, to January 21, 2015. To see all 46 images in this exhibit, go to https://www.nigms.nih.gov/education/life-magnified/Pages/default.aspx. The image is also featured in October 2015 Biomedical Beat blog post <a href="http://biobeat.nigms.nih.gov/2015/10/cool-images-a-halloween-inspired-cell-collection/" target="_">Cool Images: A Halloween-Inspired Cell Collection</a>.11/22/2022 9:13:04 PM11/22/2022 9:13:04 PMType    Name    Media Type    File Size    Modified 5_bottomright_Cells_spikey    Other 1345 KB 10/25/2020 9:22 PM Harris, Donald (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx169130https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{2A04F5B4-6212-41EE-8D4C-C4250AB717CE}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6556900Floral pattern emerging as two bacterial species, motile <i>Acinetobacter baylyi</i> and non-motile <i>Escherichia coli</i> (green), are grown together for 72 hours on 0.5% agar surface from a small inoculum in the center of a Petri dish. <br><br> See <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6557">6557</a> for a photo of this process at 24 hours on 0.75% agar surface. <br> See <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6553">6553</a> for a photo of this process at 48 hours on 1% agar surface. <br> See <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6555">6555</a> for another photo of this process at 48 hours on 1% agar surface.<br> See <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6550">6550</a> for a video of this process.12/21/2020 8:20:40 PM12/21/2020 8:20:40 PMType    Name    Media Type    File Size    Modified Fig1A_Thumb    Thumbnail 133 KB 3/23/2020 11:18 AM Harris, Donald (NIH/NIGMS) [C L. Xiong et al, eLife 2020;9 STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13360https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{650BA99B-A3DA-470B-AE76-FF69E44D891B}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3675621Stained kidney tissue. The kidney is an essential organ responsible for disposing wastes from the body and for maintaining healthy ion levels in the blood. It also secretes two hormones, erythropoietin (EPO) and calcitriol (a derivative of vitamin D), into the blood. It works like a purifier by pulling break-down products of metabolism, such as urea and ammonium, from the blood stream for excretion in urine. Related to image <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=677">3725</a>. 2/4/2020 7:58:53 PM2/4/2020 7:58:53 PMType    Name    Media Type    File Size    Modified Slide18    High 423 KB 12/1/2020 1:07 PM Walter, Taylor (NIH/NIGMS) [C The kidney is an essential organ STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx16570https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{7EE212D2-34BF-41C9-93D3-31DA36BC0BD5}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
5843644This video results from a research project to visualize which regions of the adult fruit fly (Drosophila) brain derive from each neural stem cell. First, researchers collected several thousand fruit fly larvae and fluorescently stained a random stem cell in the brain of each. The idea was to create a population of larvae in which each of the 100 or so neural stem cells was labeled at least once. When the larvae grew to adults, the researchers examined the flies’ brains using confocal microscopy. With this technique, the part of a fly’s brain that derived from a single, labeled stem cell “lights up.” The scientists photographed each brain and digitally colorized its lit-up area. By combining thousands of such photos, they created a 3-dimensional, color-coded map that shows which part of the Drosophila brain comes from each of its ~100 neural stem cells. In other words, each colored region shows which neurons are the progeny or “clones” of a single stem cell. This work established a hierarchical structure as well as nomenclature for the neurons in the Drosophila brain. Further research will relate functions to structures of the brain. Related to images <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=3745">5838</a> and <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=3808">5868</a 5/13/2022 12:38:16 PM5/13/2022 12:38:16 PMType    Name    Media Type    File Size    Modified 5843_Video 4_S    Low 110 KB 3/28/2019 2:29 PM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx16260https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{AA857D78-0446-4218-B128-C9BC7BE8FEB9}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3395456Stained cross section of the mouse tail.12/23/2020 8:12:46 PM12/23/2020 8:12:46 PMType    Name    Media Type    File Size    Modified NCMIR_mouse_tail-L    High 596 KB 2/22/2021 3:05 PM Dolan, Lauren (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15260https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{F1CB272B-5544-4534-9CFD-C4A8CCADE973}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
1101288This image of human red blood cells was obtained with the help of a scanning electron microscope, an instrument that uses a finely focused electron beam to yield detailed images of the surface of a sample.3/13/2023 7:34:30 PM3/13/2023 7:34:30 PMType    Name    Media Type    File Size    Modified RBC.B_W.Carvallo_M    Medium 47 KB 1/28/2021 8:02 AM McCulley, Jennifer (NIH/NIDCD) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx168620https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{F3C64B84-EF6C-4B97-A2A1-0C56130FFA52}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2758496This photograph shows a magnified view of a <i>Drosophila melanogaster</i> pupa in cross section. Compare this normal pupa to one that lacks an important receptor, shown in image 2759.8/21/2020 7:26:54 PM8/21/2020 7:26:54 PMType    Name    Media Type    File Size    Modified Control_S    Low 16 KB 9/14/2016 11:26 AM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13960https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{790A2C6F-2A21-48D4-8215-1A3D8B97D2B6}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
5772773Ovarioles in female insects are tubes in which egg cells (called oocytes) form at one end and complete their development as they reach the other end of the tube. This image, taken with a confocal microscope, shows ovarioles in a very popular lab animal, the fruit fly Drosophila. The basic structure of ovarioles supports very rapid egg production, with some insects (like termites) producing several thousand eggs per day. Each insect ovary typically contains 4–8 ovarioles, but this number varies widely depending on the insect species. <Br><Br>Scientists use insect ovarioles, for example, to study the basic processes that help various insects, including those that cause disease (like some mosquitos and biting flies), reproduce very quickly.12/18/2020 7:51:27 PM12/18/2020 7:51:27 PMType    Name    Media Type    File Size    Modified Kirilly04-ovaries_M    Medium 67 KB 8/4/2016 10:58 AM Varkala, Venkat (NIH/NIGMS) [C Please let me know if you have any STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx24890https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{2F3BB903-70BD-41BD-83EC-FFDE93D625AB}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
1021279A light microscope image of a cell from the endosperm of an African globe lily (<i>Scadoxus katherinae</i>). This is one frame of a time-lapse sequence that shows cell division in action. The lily is considered a good organism for studying cell division because its chromosomes are much thicker and easier to see than human ones. Staining shows microtubules in red and chromosomes in blue. Here, condensed chromosomes are clearly visible and lined up.5/9/2022 1:48:39 PM5/9/2022 1:48:39 PMType    Name    Media Type    File Size    Modified lilymit8_S    Low 12 KB 9/8/2016 2:40 PM Varkala, Venkat (NIH/NIGMS) [C A light microscope image of a cell from the endosperm of an African STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13070https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{043568AC-3AD1-48FD-97C9-60AB01D5A133}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2442197<i>Hydra magnipapillata</i> is an invertebrate animal used as a model organism to study developmental questions, for example the formation of the body axis.5/1/2024 8:30:38 PM5/1/2024 8:30:38 PMType    Name    Media Type    File Size    Modified D20_2932-2    High 588 KB 6/3/2016 3:11 PM aamishral2 (NIH/NIGMS) [C I sent the images for that purpose STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx12450https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{AFEC3CCF-4521-4FBE-B588-7EF06ED5D31B}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2801567Trajectories of single molecule labeled cell surface receptors. This is an example of NIH-supported research on single cell analysis. Related to <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2798">image 2798</a> , <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2799">image 2799</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2800">image 2800</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2802">image 2802</a> and <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2803">image 2803</a>.9/11/2020 4:15:56 PM9/11/2020 4:15:56 PMType    Name    Media Type    File Size    Modified nih11SingleMoleculeReceptors__2_S    Low 48 KB 8/24/2016 3:39 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx10160https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{EBE2CF37-7DF8-463D-B36C-83086E86C45C}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3556670Luciferase-based imaging enables visualization and quantification of internal organs and transplanted cells in live adult zebrafish. In this image, a cardiac muscle-restricted promoter drives firefly luciferase expression. Lateral (Top) and overhead views (Bottom) are shown.10/5/2020 5:20:22 AM10/5/2020 5:20:22 AMType    Name    Media Type    File Size    Modified Poss-zebrafish-01    High 416 KB 6/3/2016 3:31 PM aamishral2 (NIH/NIGMS) [C br>For imagery of the overhead STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx16470https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{3D1F01B8-728A-4F3D-B381-CF2B50DEAA2C}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6586950Cell-like compartments that spontaneously emerged from scrambled frog eggs. Endoplasmic reticulum (red) and microtubules (green) are visible. Image created using epifluorescence microscopy. <br> <p>For more photos of cell-like compartments from frog eggs view: <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6584">6584</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6585">6585</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6591">6591</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6592">6592</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6593">6593</a>.</p> <p>For videos of cell-like compartments from frog eggs view:&nbsp;<a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6587">6587</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6588">6588</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6589">6589</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6590">6590</a>.</p>9/13/2020 3:23:07 PM9/13/2020 3:23:07 PMType    Name    Media Type    File Size    Modified img3_cheng_epi_pos6_t119_M    Medium 134 KB 9/15/2020 10:08 AM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13470https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{5481E967-5FA6-4997-BBA7-D27BF6098042}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6781869The green spots in this mouse brain are cells labeled with Calling Cards, a technology that records molecular events in brain cells as they mature. Understanding these processes during healthy development can guide further research into what goes wrong in cases of neuropsychiatric disorders. Also fluorescently labeled in this video are neurons (red) and nuclei (blue). Calling Cards and its application are described in the <em>Cell</em> paper “<a href=https://www.sciencedirect.com/science/article/pii/S009286742030814X>Self-Reporting Transposons Enable Simultaneous Readout of Gene Expression and Transcription Factor Binding in Single Cells</a>” by Moudgil et al.; and the <em>Proceedings of the National Academy of Sciences</em> paper “<a href=https://www.pnas.org/content/117/18/10003>A viral toolkit for recording transcription factor–DNA interactions in live mouse tissues</a>” by Cammack et al. This video was created for the <em>NIH Director’s Blog</em> post <a href=https://directorsblog.nih.gov/2021/08/24/the-amazing-brain-tracking-molecular-events-with-calling-cards-in-the-living-brain>The Amazing Brain: Tracking Molecular Events with Calling Cards</a>. <Br><Br> Related to image <a href=https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6780>6780</a>.7/17/2023 4:43:08 PM7/17/2023 4:43:08 PMType    Name    Media Type    File Size    Modified mouse-brain-2-720_mp4_hd    Other 21462 KB 9/10/2021 1:14 PM Dolan, Lauren (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx12960https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{159782BB-22BC-4404-AACB-1A0649C7AB3B}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
1287293Bean-shaped mitochondria are cells' power plants. These organelles have their own DNA and replicate independently. The highly folded inner membranes are the site of energy generation. Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.10/28/2020 5:15:55 PM10/28/2020 5:15:55 PMType    Name    Media Type    File Size    Modified ITC_Mito_inset_Copy_M    Medium 22 KB 10/28/2020 1:15 PM McCulley, Jennifer (NIH/NIDCD) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx11150https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{78E207D8-041C-410F-8160-62D0F6BA71F5}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6356651Related to image 6355: https://images.nigms.nih.gov/Pages/DetailPage.aspx?imageID2=6355. 11/1/2021 2:30:24 PM11/1/2021 2:30:24 PMType    Name    Media Type    File Size    Modified Flu virus 2 Amaro_M    Medium 141 KB 12/11/2017 11:40 AM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx11350https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{ABE1F48D-2D0D-4405-860E-872EB8DCC54B}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
1052214Stereo triplet of a sea urchin embryo stained to reveal actin filaments (orange) and microtubules (blue). This image is part of a series of images: <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1047">image 1047</a> , <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1048">image 1048</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1049">image 1049</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1050">image 1050</a> and <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1051">image 1051</a>.8/14/2020 6:10:50 PM8/14/2020 6:10:50 PMType    Name    Media Type    File Size    Modified triplet8_S    Low 11 KB 9/8/2016 2:12 PM Varkala, Venkat (NIH/NIGMS) [C Stereo triplet of a sea urchin embryo STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx138100https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{8B140C61-F13C-462B-9A3C-226DCB9E6868}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2473136Sugars light up the cells in this jaw of a 3-day-old zebrafish embryo and highlight a scientific first: labeling and tracking the movements of sugar chains called glycans in a living organism. Here, recently produced glycans (red) are on the cell surface while those made earlier in development (green) have migrated into the cells. In some areas, old and new glycans mingle (yellow). A better understanding of such traffic patterns could shed light on how organisms develop and may uncover markers for disease, such as cancer. Featured in the May 21, 2008 of <a href=http://publications.nigms.nih.gov/biobeat/08-05-21/index.html#1 target="_blank"><i>Biomedical Beat</i></a>.8/21/2020 9:08:18 PM8/21/2020 9:08:18 PMType    Name    Media Type    File Size    Modified glowing_glycan_S    Low 32 KB 9/13/2016 4:09 PM Varkala, Venkat (NIH/NIGMS) [C Sugars light up the cells in STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13370https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{B91060A2-F13B-4A09-BD5C-3BE494CB9E7B}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131