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NIH RePORTER
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Current NIGMS Funding Opportunities
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All Funding Opportunities
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Post-Award Information
Talking to NIH Staff About Your Application and Grant
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Attribution of NIH/NIGMS Support
Message to NIGMS Investigators
NIH RePORTER
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1047
2995
Stereo triplet of a sea urchin embryo stained to reveal actin filaments (orange) and microtubules (blue). This image is part of a series of images: <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1048">image 1048</a> , <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1049">image 1049</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1050">image 1050</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1051">image 1051</a> and <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1052">image 1052</a>.
8/14/2020 5:54:53 PM
8/14/2020 5:54:53 PM
Type Name Media Type File Size Modified
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Stereo triplet of a sea urchin embryo
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Stereo triplet of a sea urchin embryo stained to reveal actin filaments (orange) and microtubules (blue). This image is part of a series of images: <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1047">image 1047</a> , <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1048">image 1048</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1050">image 1050</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1051">image 1051</a> and <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1052">image 1052</a>.
8/14/2020 6:02:18 PM
8/14/2020 6:02:18 PM
Type Name Media Type File Size Modified
triplet3_S Low 8 KB 9/8/2016 2:18 PM Varkala, Venkat (NIH/NIGMS) [C
Stereo triplet of a sea urchin embryo
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Glial cells (stained green) in a fruit fly developing embryo have survived thanks to a signaling pathway initiated by neighboring nerve cells (stained red).
8/27/2020 8:56:25 PM
8/27/2020 8:56:25 PM
Type Name Media Type File Size Modified
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Sensory organs have cells equipped for detecting signals from the environment, such as odors. Receptors in the membranes of nerve cells in the nose bind to odor molecules, triggering a cascade of chemical reactions tranferred by G proteins into the cytoplasm. Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.
10/28/2020 7:26:43 PM
10/28/2020 7:26:43 PM
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As an egg cell develops, a process called polarization controls what parts ultimately become the embryo's head and tail. This picture shows an egg of the fruit fly <i>Drosophila</i>. Red and green mark two types of signaling proteins involved in polarization. Disrupting these signals can scramble the body plan of the embryo, leading to severe developmental disorders. Featured in the September 19, 2006, issue of <a href=http://publications.nigms.nih.gov/biobeat/06-09-19/#1 target="_blank"><em>Biomedical Beat</em></a>.
10/29/2020 12:54:35 PM
10/29/2020 12:54:35 PM
Type Name Media Type File Size Modified
2309_cell_polarity_S Low 49 KB 3/29/2019 1:54 PM Constantinides, Stephen (NIH/NIGMS) [C
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Actin (purple), microtubules (yellow), and nuclei (green) are labeled in these cells by immunofluorescence. This image won first place in the Nikon 2003 Small World photo competition.
8/17/2020 9:33:48 PM
8/17/2020 9:33:48 PM
Type Name Media Type File Size Modified
Wittmann1_S Low 88 KB 9/7/2016 3:02 PM Varkala, Venkat (NIH/NIGMS) [C
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A light microscope image of a cell from the endosperm of an African globe lily (<i>Scadoxus katherinae</i>). This is one frame of a time-lapse sequence that shows cell division in action. The lily is considered a good organism for studying cell division because its chromosomes are much thicker and easier to see than human ones. Staining shows microtubules in red and chromosomes in blue. Here, condensed chromosomes are clearly visible and are starting to line up.
5/9/2022 1:46:20 PM
5/9/2022 1:46:20 PM
Type Name Media Type File Size Modified
lilymit6_S Low 13 KB 9/8/2016 2:35 PM Varkala, Venkat (NIH/NIGMS) [C
Here, condensed chromosomes are clearly visible and are starting to line up
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Two models for how material passes through the Golgi apparatus: the vesicular shuttle model and the cisternae maturation model. You can see animations of the two different models at <a href="http://publications.nigms.nih.gov/insidethecell/extras/" target="_blank">http://publications.nigms.nih.gov/insidethecell/extras/</a>. Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.
10/28/2020 4:37:04 PM
10/28/2020 4:37:04 PM
Type Name Media Type File Size Modified
ITC_GolgiTheories_S Low 69 KB 8/24/2016 5:17 PM Varkala, Venkat (NIH/NIGMS) [C
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Cells function within organs and tissues, such as the lungs, heart, intestines, and kidney. Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.
10/28/2020 4:39:12 PM
10/28/2020 4:39:12 PM
Type Name Media Type File Size Modified
ITC_TorsoTubesQuarto_M Medium 215 KB 6/3/2016 2:51 PM aamishral2 (NIH/NIGMS) [C
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Nerve cells have long, invisibly thin fibers that carry electrical impulses throughout the body. Some of these fibers extend about 3 feet from the spinal cord to the toes. Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.
10/28/2020 8:33:07 PM
10/28/2020 8:33:07 PM
Type Name Media Type File Size Modified
ITC_Neuron_lg_Copy_M Medium 273 KB 6/3/2016 2:52 PM aamishral2 (NIH/NIGMS) [C
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The plasma membrane is a cell's protective barrier Featured in <a href=http://publications.nigms.nih.gov/chemhealth/ target="_blank"><i>The Chemistry of Health</i></a>.
3/4/2022 8:02:56 PM
3/4/2022 8:02:56 PM
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Plasma_Membrane_S Low 81 KB 8/24/2016 3:47 PM Varkala, Venkat (NIH/NIGMS) [C
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The three fibers of the cytoskeleton--microtubules in blue, intermediate filaments in red, and actin in green--play countless roles in the cell. Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.
10/28/2020 4:14:44 PM
10/28/2020 4:14:44 PM
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ITC_Cytoskeleton_S Low 144 KB 8/24/2016 3:18 PM Varkala, Venkat (NIH/NIGMS) [C
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<i>Borrelia burgdorferi</i> is a spirochete, a class of long, slender bacteria that typically take on a coiled shape. Infection with this bacterium causes Lyme disease.
3/13/2023 7:26:43 PM
3/13/2023 7:26:43 PM
Type Name Media Type File Size Modified
lyme4-neg_M Medium 150 KB 10/28/2020 11:56 AM McCulley, Jennifer (NIH/NIDCD) [C
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Colorized scanning electron micrographs progressively zoom in on the eye of a crab larva. In the higher-resolution frames, bacteria are visible on the eye.
3/13/2023 7:24:39 PM
3/13/2023 7:24:39 PM
Type Name Media Type File Size Modified
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Cells keep time to know when to retire. Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.
10/28/2020 7:49:32 PM
10/28/2020 7:49:32 PM
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A cell in anaphase during mitosis: Chromosomes separate into two genetically identical groups and move to opposite ends of the spindle. Mitosis is responsible for growth and development, as well as for replacing injured or worn out cells throughout the body. For simplicity, mitosis is illustrated here with only six chromosomes. Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.
10/28/2020 8:03:57 PM
10/28/2020 8:03:57 PM
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<i>Hydra magnipapillata</i> is an invertebrate animal used as a model organism to study developmental questions, for example the formation of the body axis.
8/19/2020 2:54:54 PM
8/19/2020 2:54:54 PM
Type Name Media Type File Size Modified
D20_2927-2 High 1343 KB 6/3/2016 3:11 PM aamishral2 (NIH/NIGMS) [C
I sent the images for that purpose
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Force vectors computed from actin cytoskeleton flow. This is an example of NIH-supported research on single cell analysis. Related to <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2798">image 2798</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2800">image 2800</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2801">image 2801</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2802">image 2802</a> and <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2803">image 2803</a>.
9/11/2020 4:23:33 PM
9/11/2020 4:23:33 PM
Type Name Media Type File Size Modified
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A rendering of an activity biosensor image overlaid with a cell-centered frame of reference used for image analysis of signal transduction. This is an example of NIH-supported research on single cell analysis. Related to <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2798">image 2798</a> , <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2799">image 2799</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2800">image 2800</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2801">image 2801</a> and <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2803">image 2803</a>.
9/11/2020 4:25:46 PM
9/11/2020 4:25:46 PM
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Confocal image showing high levels of the protein vimentin (white) at the edge zone of a quail embryo. Cell nuclei are labeled green. More specifically, this high-magnification (60X) image shows vimentin immunofluorescence in the edge zone (top of image) and inner zone (bottom of image) of a Stage 4 quail blastoderm. Vimentin expression (white) is shown merged with Sytox nuclear labeling (green) at the edge of the blastoderm. A thick vimentin filament runs circumferentially (parallel to the direction of the edge) that appears to delineate the transition between the edge zone and interior zone. Also shown are dense vimentin clusters or foci, which typically appear to be closely associated with edge cell nuclei. This image appeared in a <a href=http://gtresearchnews.gatech.edu/quail-embryo/ target="_blank">March 2011 Georgia Tech news release</a>. An NIGMS grant to Professor Garcia was used to purchase the confocal microscope that collected this image. Related entries: 2808 and 2809.
12/22/2020 4:28:11 PM
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The human skin cells pictured contain genetic modifications that make them pluripotent, essentially equivalent to embryonic stem cells. A scientific team from the University of Wisconsin-Madison including researchers Junying Yu, James Thomson, and their colleagues produced the transformation by introducing a set of four genes into human fibroblasts, skin cells that are easy to obtain and grow in culture.
10/30/2020 7:29:57 PM
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When a molecule arrives at a cell's outer membrane, the membrane creates a pouch around the molecule that protrudes inward. Directed by a protein called dynamin, the pouch then gets pinched off to form a vesicle that carries the molecule to the right place inside the cell. To better understand how dynamin performs its vital pouch-pinching role, researchers determined its structure. Based on the structure, they proposed that a dynamin "collar" at the pouch's base twists ever tighter until the vesicle pops free. Because cells absorb many drugs through vesicles, the discovery could lead to new drug delivery methods. Featured in the May 19, 2010, issue of <a href=http://publications.nigms.nih.gov/biobeat/10-05-19/index.html#3 target="_blank"><em>Biomedical Beat</em></a>.
8/18/2020 7:28:26 PM
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This fluorescent microscope image shows human ES cells whose nuclei are stained green. Blue staining shows the surrounding supportive feeder cells. Image and caption information courtesy of the California Institute for Regenerative Medicine. See related image 3275.
12/22/2020 6:30:07 PM
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This image shows hundreds of human embryonic stem cells in various stages of differentiating into neurons. Some cells have become neurons (red), while others are still precursors of nerve cells (green). The yellow is an imaging artifact resulting wehn cells in both stages are on top of each other. Image and caption information courtesy of the California Institute for Regenerative Medicine.
12/22/2020 7:13:24 PM
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It has been said that gastrulation is the most important event in a person's life. This part of early embryonic development transforms a simple ball of cells and begins to define cell fate and the body axis. In a study published in Science magazine in March 2012, NIGMS grantee Bob Goldstein and his research group studied how contractions of actomyosin filaments in C. elegans and Drosophila embryos lead to dramatic rearrangements of cell and embryonic structure. This research is described in detail in the following <a href=http://www.sciencemag.org/content/335/6073/1232.abstract target="_blank"> article</a>: "Triggering a Cell Shape Change by Exploiting Preexisting Actomyosin Contractions." In these images, myosin (green) and plasma membrane (red) are highlighted at four timepoints in gastrulation in the roundworm C. elegans. The blue highlights in the top three frames show how cells are internalized, and the site of closure around the involuting cells is marked with an arrow in the last frame. See related image 3297.
3/18/2022 4:17:40 PM
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Like a pulsing blue shower, E. coli cells flash in synchrony. Genes inserted into each cell turn a fluorescent protein on and off at regular intervals. When enough cells grow in the colony, a phenomenon called quorum sensing allows them to switch from blinking independently to blinking in unison. Researchers can watch waves of light propagate across the colony. Adjusting the temperature, chemical composition or other conditions can change the frequency and amplitude of the waves. Because the blinks react to subtle changes in the environment, synchronized oscillators like this one could one day allow biologists to build cellular sensors that detect pollutants or help deliver drugs. This image was featured in the January 20, 2010 issue of <a href=http://publications.nigms.nih.gov/biobeat/10-01-20/index.html#1 target="_blank"><i>Biomedical Beat</i></a>.
8/12/2020 3:48:40 PM
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A combo of protein structures determined experimentally and computationally shows us the complete metabolic network of a heat-loving bacterium.
8/6/2020 4:36:05 PM
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This photograph shows a magnified view of a <i>Drosophila melanogaster</i> pupa in cross section. Compare this normal pupa to one that lacks an important receptor, shown in image 2759.
8/21/2020 7:26:54 PM
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In the absence of the engulfment receptor Draper, salivary gland cells (light blue) persist in the thorax of a developing <i>Drosophila melanogaster</i> pupa. See image 2758 for a cross section of a normal pupa that does express Draper.
8/21/2020 7:28:19 PM
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Spinal nerves are part of the peripheral nervous system. They run within the spinal column to carry nerve signals to and from all parts of the body. The spinal nerves enable all the movements we do, from turning our heads to wiggling our toes, control the movements of our internal organs, such as the colon and the bladder, as well as allow us to feel touch and location of our limbs.
12/23/2020 8:04:47 PM
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Watch a cell ripple toward a beam of light that turns on a movement-related protein.
10/19/2020 6:08:59 AM
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Of the three muscle fibers shown here, the one on the right and the one on the left are normal. The middle fiber is deficient a large protein called nebulin (blue). Nebulin plays a number of roles in the structure and function of muscles, and its absence is associated with certain neuromuscular disorders. This image is part of the Life: Magnified collection, which was displayed in the Gateway Gallery at Washington Dulles International Airport June 3, 2014, to January 21, 2015. To see all 46 images in this exhibit, go to https://www.nigms.nih.gov/education/life-magnified/Pages/default.aspx.
11/22/2022 7:51:47 PM
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Anaphase is the critical step during mitosis when sister chromosomes are disjoined and directed to opposite spindle poles, ensuring equal distribution of the genome during cell division. In this image, one pair of sister chromosomes at the top was lost and failed to divide after chemical inhibition of polo-like kinase 1. This image depicts chromosomes (blue) separating away from the spindle mid-zone (red). Kinetochores (green) highlight impaired movement of some chromosomes away from the mid-zone or the failure of sister chromatid separation (top). Scientists are interested in detailing the signaling events that are disrupted to produce this effect. The image is a volume projection of multiple deconvolved z-planes acquired with a Nikon widefield fluorescence microscope. This image was chosen as a winner of the 2016 NIH-funded research image call. Related to <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=3054">image 5765</a>. <Br><Br> The research that led to this image was funded by NIGMS.
5/13/2022 12:51:55 PM
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Composite image of beta-galactosidase showing how cryo-EM’s resolution has improved dramatically in recent years. Older images to the left, more recent to the right. Related to image <a href="https://images.nigms.nih.gov/Pages/DetailPage.aspx?imageID2=5882">5882</a>. NIH Director Francis Collins featured this on his blog on January 14, 2016. See<a href="https://directorsblog.nih.gov/2016/01/14/got-it-down-cold-cryo-electron-microscopy-named-method-of-the-year/"> Got It Down Cold: Cryo-Electron Microscopy Named Method of the Year </a>
12/18/2020 9:52:10 PM
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Dengue virus is a mosquito-borne illness that infects millions of people in the tropics and subtropics each year. Like many viruses, dengue is enclosed by a protective membrane. The proteins that span this membrane play an important role in the life cycle of the virus. Scientists used cryo-EM to determine the structure of a dengue virus at a 3.5-angstrom resolution to reveal how the membrane proteins undergo major structural changes as the virus matures and infects a host. For more on cryo-EM see the blog post <a href="https://biobeat.nigms.nih.gov/2016/02/cryo-electron-microscopy-reveals-molecules-in-ever-greater-detail/">Cryo-Electron Microscopy Reveals Molecules in Ever Greater Detail</a>. For a still image of the dengue virus surface structure, see <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3756">image 3756.<a>
12/17/2020 5:44:50 PM
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Some nerve cells (neurons) in the brain keep track of the daily cycle. This time-keeping mechanism, called the circadian clock, is found in all animals including us. The circadian clock controls our daily activities such as sleep and wakefulness. Researchers are interested in finding the neuron circuits involved in this time keeping and how the information about daily time in the brain is relayed to the rest of the body. In this image of a brain of the fruit fly Drosophila, the time-of-day information flowing through the brain has been visualized by staining the neurons involved: clock neurons (shown in blue) function as "pacemakers" by communicating with neurons that produce a short protein called leucokinin (LK) (red), which, in turn, relays the time signal to other neurons, called LK-R neurons (green). This signaling cascade set in motion by the pacemaker neurons helps synchronize the fly's daily activity with the 24-hour cycle. To learn more about what scientist have found out about circadian pacemaker neurons in the fruit fly <a href="http://www.nyu.edu/about/news-publications/news/2016/02/29/biological-clocks-orchestrate-behavioral-rhythms-by-sending-signals-downstream.html">see this news release by New York University</a>. A study describing the discovery of the neuron circuits involved has been published in the journal <a href="http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.4263.html"><i>Nature Neuroscience</i></a> This work was featured in the <i>Biomedical Beat</i> blog post <a href="https://biobeat.nigms.nih.gov/2016/03/cool-image-a-circadian-circuit/">Cool Image: A Circadian Circuit.</a>
12/17/2020 6:17:16 PM
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Pigment cells are cells that give skin its color. In fishes and amphibians, like frogs and salamanders, pigment cells are responsible for the characteristic skin patterns that help these organisms to blend into their surroundings or attract mates. The pigment cells are derived from neural crest cells, which are cells originating from the neural tube in the early embryo. This image shows pigment cells from pearl danio, a relative of the popular laboratory animal zebrafish. Investigating pigment cell formation and migration in animals helps answer important fundamental questions about the factors that control pigmentation in the skin of animals, including humans. Related to images <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=2996">5754</a>, <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=3000">5755</a>, <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=3011">5757</a> and <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=3016">5758.
12/18/2020 4:53:41 PM
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I’d be happy to make some high
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This image results from a research project to visualize which regions of the adult fruit fly (Drosophila) brain derive from each neural stem cell. First, researchers collected several thousand fruit fly larvae and fluorescently stained a random stem cell in the brain of each. The idea was to create a population of larvae in which each of the 100 or so neural stem cells was labeled at least once. When the larvae grew to adults, the researchers examined the flies’ brains using confocal microscopy. </br>With this technique, the part of a fly’s brain that derived from a single, labeled stem cell “lights up.” The scientists photographed each brain and digitally colorized its lit-up area. By combining thousands of such photos, they created a 3-dimensional, color-coded map that shows which part of the Drosophila brain comes from each of its ~100 neural stem cells. In other words, each colored region shows which neurons are the progeny or “clones” of a single stem cell. This work established a hierarchical structure as well as nomenclature for the neurons in the Drosophila brain. Further research will relate functions to structures of the brain. Related to image <a href="/Pages/DetailPage.aspx?imageID2=5838">5838</a> and video<a href="/Pages/DetailPage.aspx?imageID2=5843"> 5843</a>.
5/13/2022 12:37:47 PM
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Luciferase-based imaging enables visualization and quantification of internal organs and transplanted cells in live adult zebrafish. In this image, a cardiac muscle-restricted promoter drives firefly luciferase expression. Lateral (Top) and overhead views (Bottom) are shown.
10/5/2020 5:20:22 AM
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The lubber grasshopper, found throughout the southern United States, is frequently used in biology classes to teach students about the respiratory system of insects. Unlike mammals, which have red blood cells that carry oxygen throughout the body, insects have breathing tubes that carry air through their exoskeleton directly to where it's needed. This image shows the breathing tubes embedded in the weblike sheath cells that cover developing egg chambers. This image is part of the Life: Magnified collection, which was displayed in the Gateway Gallery at Washington Dulles International Airport June 3, 2014, to January 21, 2015. To see all 46 images in this exhibit, go to https://www.nigms.nih.gov/education/life-magnified/Pages/default.aspx.
11/28/2022 9:47:06 PM
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This image shows a normal fibroblast, a type of cell that is common in connective tissue and frequently studied in research labs. This cell has a healthy skeleton composed of actin (red) and microtubles (green). Actin fibers act like muscles to create tension and microtubules act like bones to withstand compression. This image is part of the Life: Magnified collection, which was displayed in the Gateway Gallery at Washington Dulles International Airport June 3, 2014, to January 21, 2015. To see all 46 images in this exhibit, go to https://www.nigms.nih.gov/education/life-magnified/Pages/default.aspx.
11/22/2022 9:18:45 PM
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A microtubule, part of the cell's skeleton, builds and deconstructs.
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This image results from a research project to visualize which regions of the adult fruit fly (Drosophila) brain derive from each neural stem cell. First, researchers collected several thousand fruit fly larvae and fluorescently stained a random stem cell in the brain of each. The idea was to create a population of larvae in which each of the 100 or so neural stem cells was labeled at least once. When the larvae grew to adults, the researchers examined the flies’ brains using confocal microscopy. With this technique, the part of a fly’s brain that derived from a single, labeled stem cell “lights up.” The scientists photographed each brain and digitally colorized its lit-up area. By combining thousands of such photos, they created a 3-dimensional, color-coded map that shows which part of the Drosophila brain comes from each of its ~100 neural stem cells. In other words, each colored region shows which neurons are the progeny or “clones” of a single stem cell. This work established a hierarchical structure as well as nomenclature for the neurons in the Drosophila brain. Further research will relate functions to structures of the brain. Related to image <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=3808">5868</a> and video<a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=3749"> 5843</a>
5/13/2022 12:38:45 PM
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12/21/2020 5:16:04 PM
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This image is a computer-generated model of the approximately 4.2 million atoms of the HIV capsid, the shell that contains the virus' genetic material. Scientists determined the exact structure of the capsid and the proteins that it's made of using a variety of imaging techniques and analyses. They then entered these data into a supercomputer that produced the atomic-level image of the capsid. This structural information could be used for developing drugs that target the capsid, possibly leading to more effective therapies
11/14/2023 1:23:33 PM
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This structural information could be used for developing
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A mouse's fat cells (red) are shown surrounded by a network of blood vessels (green). Fat cells store and release energy, protect organs and nerve tissues, insulate us from the cold and help us absorb important vitamins. This image is part of the Life: Magnified collection, which was displayed in the Gateway Gallery at Washington Dulles International Airport June 3, 2014, to January 21, 2015. To see all 46 images in this exhibit, go to https://www.nigms.nih.gov/education/life-magnified/Pages/default.aspx.
11/22/2022 8:43:42 PM
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Each of the colored specs in this image is a cell on the surface of a fish scale. To better understand how wounds heal, scientists have inserted genes that make cells brightly glow in different colors into the skin cells of zebrafish, a fish often used in laboratory research. The colors enable the researchers to track each individual cell, for example, as it moves to the location of a cut or scrape over the course of several days. These technicolor fish endowed with glowing skin cells dubbed "skinbow" provide important insight into how tissues recover and regenerate after an injury. <Br><Br>For more information on skinbow fish, see the Biomedical Beat blog post <a href="https://biobeat.nigms.nih.gov/2016/04/visualizing-skin-regeneration-in-real-time/">Visualizing Skin Regeneration in Real Time</a> and <a href="http://today.duke.edu/2016/03/zebrafish">a press release from Duke University highlighting this research</a>. Related to <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=717"> image 3783</a>.
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