3791

Add to My Images

Large-Resolution Video


316 KB
   Download

Nucleolus subcompartments spontaneously self-assemble 2

ID Number
3791

Description
The nucleolus is a small but very important protein complex located in the cell's nucleus. It forms on the chromosomes at the location where the genes for the RNAs are that make up the structure of the ribosome, the indispensable cellular machine that make proteins from messenger RNAs.

However, how the nucleolus grows and maintains its structure has puzzled scientists for some time. It turns out that even though it looks like a simple liquid blob, it's rather well-organized, consisting of three distinct layers: the fibrillar center, where the RNA polymerase is active; the dense fibrillar component, which is enriched in the protein fibrillarin; and the granular component, which contains a protein called nucleophosmin. Researchers have now discovered that this multilayer structure of the nucleolus arises from differences in how the proteins in each compartment mix with water and with each other. These differences let the proteins readily separate from each other into the three nucleolus compartments.

This video of nucleoli in the eggs of a commonly used lab animal, the frog Xenopus laevis, shows how each of the compartments (the granular component is shown in red, the fibrillarin in yellow-green, and the fibrillar center in blue) spontaneously fuse with each other on encounter without mixing with the other compartments.

For more details on this research, see this press release from Princeton. Related to video 3789, image 3792 and image 3793.

Type
Video

Source
Nilesh Vaidya, Princeton University

Credit Line
Nilesh Vaidya and Clifford Brangwynne, Princeton University

 


Back to Search Results | New Search
​​​​​​​​​​​​

Related Information

Dr. Lola Eniola-Adefeso, Ph.D.Scientist Interviews, Profiles and Photos

Developing zebrafish fin. Courtesy of Jessica Plavicki, University of Wisconsin, Madison.Stunning Images of Cells and More in
"Life: Magnified"

NIH Image GalleryNIH Image Gallery Link to external Web site

NCBI Organism: Plasmodium yoelii nigeriensis, anopheles stephensi cell types: oocyst cellular components: cyst wall biological process: sporozoan zygote development.The Cell: An Image Library Link to external Web site

NIGMS InstagramInstagram
Visit NIGMS on Instagram

NIGMS on iTunes UNIGMS on iTunes U

​​​​​​​​​​​​​

My Images

No images to display.


Note: Some of the files in this gallery may require a content viewer.
This page last reviewed on January 4, 2017