Detail Page

  • 14091393588837170369614623535134825704PublicAssets/5768Collecting and transporting cellular waste and sorting it into recylable and nonrecylable pieces is a complex business in the cell. One key player in that process is the endosome, which helps collect, sort and transport worn-out or leftover proteins with the help of a protein assembly called the endosomal sorting complexes for transport (or ESCRT for short). These complexes help package proteins marked for breakdown into intralumenal vesicles, which, in turn, are enclosed in multivesicular bodies for transport to the places where the proteins are recycled or dumped. In this image, a multivesicular body (the round structure slightly to the right of center) contain tiny intralumenal vesicles (with a diameter of only 25 nanometers; the round specks inside the larger round structure) adjacent to the cell's vacuole (below the multivesicular body, shown in darker and more uniform gray). <Br><Br>Scientists working with baker's yeast (<i>Saccharomyces cerevisiae</i>) study the budding inward of the limiting membrane (green lines on top of the yellow lines) into the intralumenal vesicles. This tomogram was shot with a Tecnai F-20 high-energy electron microscope, at 29,000x magnification, with a 0.7-nm pixel, ~4-nm resolution. <Br><Br>To learn more about endosomes, see the <i>Biomedical Beat</i> blog post <a href="https://biobeat.nigms.nih.gov/2016/07/the-cells-mailroom/">The Cell’s Mailroom</a>. Related to a color-enhanced version <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=5767">5767</a> and image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=5769">5769</a>.Matthew West and Greg Odorizzi, University of ColoradoMatthew West and Greg Odorizzi, University of ColoradoPhotograph

    Topic Tags:

    CellsTools and Techniques

    Multivesicular bodies containing intralumenal vesicles assemble at the vacuole 2

    View EntryAdd to My Images

    Collecting and transporting cellular waste and sorting it into recylable and nonrecylable pieces is a complex business in the cell. One key player in that process is the endosome, which helps collect, sort and transport worn-out or leftover proteins with the help of a protein assembly called the endosomal sorting complexes for transport (or ESCRT for short). These complexes help package proteins marked for breakdown into intralumenal vesicles, which, in turn, are enclosed in multivesicular bodies for transport to the places where the proteins are recycled or dumped. In this image, a multivesicular body (the round structure slightly to the right of center) contain tiny intralumenal vesicles (with a diameter of only 25 nanometers; the round specks inside the larger round structure) adjacent to the cell's vacuole (below the multivesicular body, shown in darker and more uniform gray).

    Scientists working with baker's yeast (Saccharomyces cerevisiae) study the budding inward of the limiting membrane (green lines on top of the yellow lines) into the intralumenal vesicles. This tomogram was shot with a Tecnai F-20 high-energy electron microscope, at 29,000x magnification, with a 0.7-nm pixel, ~4-nm resolution.

    To learn more about endosomes, see the Biomedical Beat blog post The Cell’s Mailroom. Related to a color-enhanced version 5767 and image 5769.

    Source

    Matthew West and Greg Odorizzi, University of Colorado

    Credit Line

    Matthew West and Greg Odorizzi, University of Colorado

    Record Type

    Photograph

    ID

    5768

My Images/Videos