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  • 24919131PublicAssets/5730Gene transcription is a process by which information encoded in DNA is transcribed into RNA. It's essential for all life and requires the activity of proteins, called transcription factors, that detect where in a DNA strand transcription should start. In eukaryotes (i.e., those that have a nucleus and mitochondria), a protein complex comprising 14 different proteins is responsible for sniffing out transcription start sites and starting the process. This complex represents the core machinery to which an enzyme, named RNA polymerase, can bind to and read the DNA and transcribe it to RNA. Scientists have used cryo-electron microscopy (cryo-EM) to visualize the TFIID-RNA polymerase-DNA complex in unprecedented detail. This animation shows the different TFIID components as they contact DNA and recruit the RNA polymerase for gene transcription. <br><br>To learn more about the research that has shed new light on gene transcription, see this <a href="http://newscenter.lbl.gov/2016/03/23/unlocking-the-secrets-of-gene-expression/">news release from Berkeley Lab</a>. <br><br>Related to <a href="https://images.nigms.nih.gov/Pages/DetailPage.aspx?imageid2=3766">image 3766</a>.Eva Nogales, Berkeley LabRobert Louder, Berkeley LabVideo

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    GenesMolecular StructuresTools and Techniques

    Dynamic cryo-EM model of the human transcription preinitiation complex

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    Gene transcription is a process by which information encoded in DNA is transcribed into RNA. It's essential for all life and requires the activity of proteins, called transcription factors, that detect where in a DNA strand transcription should start. In eukaryotes (i.e., those that have a nucleus and mitochondria), a protein complex comprising 14 different proteins is responsible for sniffing out transcription start sites and starting the process. This complex represents the core machinery to which an enzyme, named RNA polymerase, can bind to and read the DNA and transcribe it to RNA. Scientists have used cryo-electron microscopy (cryo-EM) to visualize the TFIID-RNA polymerase-DNA complex in unprecedented detail. This animation shows the different TFIID components as they contact DNA and recruit the RNA polymerase for gene transcription.

    To learn more about the research that has shed new light on gene transcription, see this news release from Berkeley Lab.

    Related to image 3766.

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    Eva Nogales, Berkeley Lab

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    Robert Louder, Berkeley Lab

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    Video

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    5730

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