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  • 876950PublicAssets/3728To simulate the consequences of disrupting bacterial cell-to-cell communication, called quorum sensing, in the crypts (small chambers within the colon), the researchers experimented with an inhibitor molecule (i.e., antagonist) to turn off quorum sensing in methicillin-resistant Staphylococcus aureus (MRSA), an antibiotic-resistant strain of bacteria that often causes human infections. In this experiment, a medium promoting bacterial growth flows through experimental chambers mimicking the colon environment. The chambers on the right contained no antagonist. In the left chambers, after being added to the flowing medium, the quorum-sensing-inhibiting molecules quickly spread throughout the crevices, inactivating quorum sensing and reducing colonization. These results suggest a potential strategy for addressing MRSA virulence via inhibitors of bacterial communication. You can read more about this research <a href="https://www.princeton.edu/main/news/archive/S45/26/21S91/index.xml?section=topstories/">here</a>.Minyoung Kevin Kim and Bonnie Bassler, Princeton UniversityMinyoung Kevin Kim and Bonnie Bassler, Princeton UniversityVideo

    Topic Tags:

    CellsChemistry, Biochemistry, and Pharmacology

    Quorum-sensing inhibitor limits bacterial growth

    To simulate the consequences of disrupting bacterial cell-to-cell communication, called quorum sensing, in the crypts (small chambers within the colon), the researchers experimented with an inhibitor molecule (i.e., antagonist) to turn off quorum sensing in methicillin-resistant Staphylococcus aureus (MRSA), an antibiotic-resistant strain of bacteria that often causes human infections. In this experiment, a medium promoting bacterial growth flows through experimental chambers mimicking the colon environment. The chambers on the right contained no antagonist. In the left chambers, after being added to the flowing medium, the quorum-sensing-inhibiting molecules quickly spread throughout the crevices, inactivating quorum sensing and reducing colonization. These results suggest a potential strategy for addressing MRSA virulence via inhibitors of bacterial communication. You can read more about this research here.

    Source

    Minyoung Kevin Kim and Bonnie Bassler, Princeton University

    Credit Line

    Minyoung Kevin Kim and Bonnie Bassler, Princeton University

    Record Type

    Video

    ID

    3728

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