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  • 2743360012515081371180026448968590066642PublicAssets/3550The green spots in this image are clumps of protein inside yeast cells that are deficient in both zinc and a protein called Tsa1 that prevents clumping. Protein clumping plays a role in many diseases, including Parkinson's and Alzheimer's, where proteins clump together in the brain. Zinc deficiency within a cell can cause proteins to mis-fold and eventually clump together. Normally, in yeast, Tsa1 codes for so-called "chaperone proteins" which help proteins in stressed cells, such as those with a zinc deficiency, fold correctly. The research behind this image was published in 2013 in the Journal of Biological Chemistry.Colin MacDiarmid and David Eide, University of Wisconsin--MadisonColin MacDiarmid and David Eide/Journal of Biological ChemistryPhotograph

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    CellsInjury and Illness

    Protein clumping in zinc-deficient yeast cells

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    The green spots in this image are clumps of protein inside yeast cells that are deficient in both zinc and a protein called Tsa1 that prevents clumping. Protein clumping plays a role in many diseases, including Parkinson's and Alzheimer's, where proteins clump together in the brain. Zinc deficiency within a cell can cause proteins to mis-fold and eventually clump together. Normally, in yeast, Tsa1 codes for so-called "chaperone proteins" which help proteins in stressed cells, such as those with a zinc deficiency, fold correctly. The research behind this image was published in 2013 in the Journal of Biological Chemistry.

    Source

    Colin MacDiarmid and David Eide, University of Wisconsin--Madison

    Credit Line

    Colin MacDiarmid and David Eide/Journal of Biological Chemistry

    Record Type

    Photograph

    ID

    3550

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