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  • 51251217288125625641291308308116556PublicAssets/3509In this image, recombinant probes known as FingRs (Fibronectin Intrabodies Generated by mRNA display) were expressed in a cortical neuron, where they attached fluorescent proteins to either PSD95 (green) or Gephyrin (red). PSD-95 is a marker for synaptic strength at excitatory postsynaptic sites, and Gephyrin plays a similar role at inhibitory postsynaptic sites. Thus, using FingRs it is possible to obtain a map of synaptic connections onto a particular neuron in a living cell in real time. Don Arnold and Richard Roberts, University of Southern California.Jason Junge, University of Southern California.Photograph

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    Cells

    Neuron with labeled synapses

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    In this image, recombinant probes known as FingRs (Fibronectin Intrabodies Generated by mRNA display) were expressed in a cortical neuron, where they attached fluorescent proteins to either PSD95 (green) or Gephyrin (red). PSD-95 is a marker for synaptic strength at excitatory postsynaptic sites, and Gephyrin plays a similar role at inhibitory postsynaptic sites. Thus, using FingRs it is possible to obtain a map of synaptic connections onto a particular neuron in a living cell in real time.

    Source

    Don Arnold and Richard Roberts, University of Southern California.

    Credit Line

    Jason Junge, University of Southern California.

    Record Type

    Photograph

    ID

    3509

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