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  • 20482048478819102410247661251251218578PublicAssets/3432Shortly after a pregnant woman gives birth, her breasts start to secrete milk. This process is triggered by hormonal and genetic cues, including the protein Elf5. Scientists discovered that Elf5 also has another job--it staves off cancer. Early in the development of breast cancer, human breast cells often lose Elf5 proteins. Cells without Elf5 change shape and spread readily--properties associated with metastasis. This image shows cells in the mouse mammary gland that are lacking Elf5, leading to the overproduction of other proteins (red) that increase the likelihood of metastasis.Nature Cell Biology, November 2012, Volume 14 No 11 pp1113-1231Rumela Chakrabarti, Princeton UniversityPhotograph

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    Cells

    Mouse mammary cells lacking anti-cancer protein

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    Shortly after a pregnant woman gives birth, her breasts start to secrete milk. This process is triggered by hormonal and genetic cues, including the protein Elf5. Scientists discovered that Elf5 also has another job--it staves off cancer. Early in the development of breast cancer, human breast cells often lose Elf5 proteins. Cells without Elf5 change shape and spread readily--properties associated with metastasis. This image shows cells in the mouse mammary gland that are lacking Elf5, leading to the overproduction of other proteins (red) that increase the likelihood of metastasis.

    Source

    Nature Cell Biology, November 2012, Volume 14 No 11 pp1113-1231

    Credit Line

    Rumela Chakrabarti, Princeton University

    Record Type

    Photograph

    ID

    3432

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