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  • 8560425114330314280212535953721401062100851PublicAssets/3429The molecule on the left is an electrostatic potential map of the van der Waals surface of the transition state for human purine nucleoside phosphorylase. The colors indicate the electron density at any position of the molecule. Red indicates electron-rich regions with negative charge and blue indicates electron-poor regions with positive charge. The molecule on the right is called DADMe-ImmH. It is a chemically stable analogue of the transition state on the left. It binds to the enzyme millions of times tighter than the substrate. This inhibitor is in human clinical trials for treating patients with gout. This image appears in Figure 4, Schramm, V.L. (2011) Annu. Rev. Biochem. 80:703-732.Vern Schramm, Albert Einstein College of Medicine of Yeshiva UniversityVern Schramm, Albert Einstein College of Medicine of Yeshiva UniversityIllustration

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    Chemistry, Biochemistry, and PharmacologyMolecular StructuresTools and Techniques

    Enzyme transition states

    The molecule on the left is an electrostatic potential map of the van der Waals surface of the transition state for human purine nucleoside phosphorylase. The colors indicate the electron density at any position of the molecule. Red indicates electron-rich regions with negative charge and blue indicates electron-poor regions with positive charge. The molecule on the right is called DADMe-ImmH. It is a chemically stable analogue of the transition state on the left. It binds to the enzyme millions of times tighter than the substrate. This inhibitor is in human clinical trials for treating patients with gout. This image appears in Figure 4, Schramm, V.L. (2011) Annu. Rev. Biochem. 80:703-732.

    Source

    Vern Schramm, Albert Einstein College of Medicine of Yeshiva University

    Credit Line

    Vern Schramm, Albert Einstein College of Medicine of Yeshiva University

    Record Type

    Illustration

    ID

    3429

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