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  • 11956581792595983295519328715836546PublicAssets/3428Structure of the bacterial antitoxin protein GhoS. GhoS inhibits the production of a bacterial toxin, GhoT, which can contribute to antibiotic resistance. GhoS is the first known bacterial antitoxin that works by cleaving the messenger RNA that carries the instructions for making the toxin. More information can be found in the paper: Wang X, Lord DM, Cheng HY, Osbourne DO, Hong SH, Sanchez-Torres V, Quiroga C, Zheng K, Herrmann T, Peti W, Benedik MJ, Page R, Wood TK. <a href="http://www.ncbi.nlm.nih.gov/pubmed/22941047" target="_blank">A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS</a>. Nat Chem Biol. 2012 Oct;8(10):855-61. Related to <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=3427">3427</a>.Rebecca Page and Wolfgang Peti, Brown University and Thomas K. Wood, Pennsylvania State UniversityRebecca Page and Wolfgang Peti, Brown University and Thomas K. Wood, Pennsylvania State UniversityIllustration

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    Molecular Structures

    Antitoxin GhoS (Illustration 2)

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    Structure of the bacterial antitoxin protein GhoS. GhoS inhibits the production of a bacterial toxin, GhoT, which can contribute to antibiotic resistance. GhoS is the first known bacterial antitoxin that works by cleaving the messenger RNA that carries the instructions for making the toxin. More information can be found in the paper: Wang X, Lord DM, Cheng HY, Osbourne DO, Hong SH, Sanchez-Torres V, Quiroga C, Zheng K, Herrmann T, Peti W, Benedik MJ, Page R, Wood TK. A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS. Nat Chem Biol. 2012 Oct;8(10):855-61. Related to 3427.

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    Rebecca Page and Wolfgang Peti, Brown University and Thomas K. Wood, Pennsylvania State University

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    Rebecca Page and Wolfgang Peti, Brown University and Thomas K. Wood, Pennsylvania State University

    Record Type

    Illustration

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    3428

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