Search the NIGMS Image and Video Gallery
Topic Tags:
Molecular Structures
When the heat shock protein hsp33 is folded, it is inactive and contains a zinc ion, stabilizing the redox sensitive domain (orange). In the presence of an environmental stressor, the protein releases the zinc ion, which leads to the unfolding of the redox domain. This unfolding causes the chaperone to activate by reaching out its "arm" (green) to protect other proteins.
Dana Reichmann, University of Michigan
Ursula Jakob and Dana Reichmann, University of Michigan
Video
3402