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Cell proliferation in a quail embryo

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Cell proliferation in a quail embryo

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Image showing that the edge zone (top of image) of the quail embryo shows no proliferating cells (cyan), unlike the interior zone (bottom of image). Non-proliferating cell nuclei are labeled green.

This image was obtained as part of a study to understand cell migration in embryos. More specifically, cell proliferation at the edge of the embryo was studied by examining the cellular uptake of a chemical compound called BrDU, which incorporates into the DNA during the S-phase of the cell cycle. Here, the cells that are positive for BrDU uptake are labeled in cyan, while other non-proliferating cell nuclei are labeled green. Notice that the vast majority of BrDU+ cells are located far away from the edge, indicating that edge cells are mostly non-proliferating.

An NIGMS grant to Professor Garcia was used to purchase the confocal microscope that collected this image. Related entries: 2807 and 2809.

This appeared in a March 2011 Georgia Tech news release.


Andrés Garcia, Georgia Tech

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Evan Zamir, Georgia Tech

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This page last reviewed on April 26, 2011